PhotoModPlus: A web server for photosynthetic protein prediction from genome neighborhood features.
A new web server called PhotoModPlus is presented as a platform for predicting photosynthetic proteins via genome neighborhood networks (GNN) and genome neighborhood-based machine learning. GNN enables users to visualize the overview of the conserved neighboring genes from multiple photosynthetic pr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0248682 |
| _version_ | 1818825240196677632 |
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| author | Apiwat Sangphukieo Teeraphan Laomettachit Marasri Ruengjitchatchawalya |
| author_facet | Apiwat Sangphukieo Teeraphan Laomettachit Marasri Ruengjitchatchawalya |
| author_sort | Apiwat Sangphukieo |
| collection | DOAJ |
| description | A new web server called PhotoModPlus is presented as a platform for predicting photosynthetic proteins via genome neighborhood networks (GNN) and genome neighborhood-based machine learning. GNN enables users to visualize the overview of the conserved neighboring genes from multiple photosynthetic prokaryotic genomes and provides functional guidance on the query input. In the platform, we also present a new machine learning model utilizing genome neighborhood features for predicting photosynthesis-specific functions based on 24 prokaryotic photosynthesis-related GO terms, namely PhotoModGO. The new model performed better than the sequence-based approaches with an F1 measure of 0.872, based on nested five-fold cross-validation. Finally, we demonstrated the applications of the webserver and the new model in the identification of novel photosynthetic proteins. The server is user-friendly, compatible with all devices, and available at bicep.kmutt.ac.th/photomod. |
| first_indexed | 2024-12-19T00:08:37Z |
| format | Article |
| id | doaj.art-a9ea46db7cd04c1ab8e8f986501ff4a4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T00:08:37Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a9ea46db7cd04c1ab8e8f986501ff4a42022-12-21T20:46:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01163e024868210.1371/journal.pone.0248682PhotoModPlus: A web server for photosynthetic protein prediction from genome neighborhood features.Apiwat SangphukieoTeeraphan LaomettachitMarasri RuengjitchatchawalyaA new web server called PhotoModPlus is presented as a platform for predicting photosynthetic proteins via genome neighborhood networks (GNN) and genome neighborhood-based machine learning. GNN enables users to visualize the overview of the conserved neighboring genes from multiple photosynthetic prokaryotic genomes and provides functional guidance on the query input. In the platform, we also present a new machine learning model utilizing genome neighborhood features for predicting photosynthesis-specific functions based on 24 prokaryotic photosynthesis-related GO terms, namely PhotoModGO. The new model performed better than the sequence-based approaches with an F1 measure of 0.872, based on nested five-fold cross-validation. Finally, we demonstrated the applications of the webserver and the new model in the identification of novel photosynthetic proteins. The server is user-friendly, compatible with all devices, and available at bicep.kmutt.ac.th/photomod.https://doi.org/10.1371/journal.pone.0248682 |
| spellingShingle | Apiwat Sangphukieo Teeraphan Laomettachit Marasri Ruengjitchatchawalya PhotoModPlus: A web server for photosynthetic protein prediction from genome neighborhood features. PLoS ONE |
| title | PhotoModPlus: A web server for photosynthetic protein prediction from genome neighborhood features. |
| title_full | PhotoModPlus: A web server for photosynthetic protein prediction from genome neighborhood features. |
| title_fullStr | PhotoModPlus: A web server for photosynthetic protein prediction from genome neighborhood features. |
| title_full_unstemmed | PhotoModPlus: A web server for photosynthetic protein prediction from genome neighborhood features. |
| title_short | PhotoModPlus: A web server for photosynthetic protein prediction from genome neighborhood features. |
| title_sort | photomodplus a web server for photosynthetic protein prediction from genome neighborhood features |
| url | https://doi.org/10.1371/journal.pone.0248682 |
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