Hemophagocytic syndrome associated to hepatitis
Hemophagocytic syndrome is characterized by increased proliferation and activation of antigen presenting cells (histiocytes) in bone marrow and other organs of the reticuloendothelial system as well as CD8+ T cells that threatens life of patients. The predominant clinical manifestations such as feve...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Colegio Mexicano de Inmunología Clínica y Alergia, A.C.
2016-03-01
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| Series: | Revista Alergia México |
| Subjects: | |
| Online Access: | http://revistaalergia.mx/ojs/index.php/ram/article/view/133 |
| _version_ | 1797712690539397120 |
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| author | Eunice Sandoval-Ramírez Ignacio Camacho-Meza Nery Eduardo-Solís Oswaldo Plascencia-Tabares Efraín Navarro-Olivos Francisco Ignacio Ortiz-Aldana |
| author_facet | Eunice Sandoval-Ramírez Ignacio Camacho-Meza Nery Eduardo-Solís Oswaldo Plascencia-Tabares Efraín Navarro-Olivos Francisco Ignacio Ortiz-Aldana |
| author_sort | Eunice Sandoval-Ramírez |
| collection | DOAJ |
| description | Hemophagocytic syndrome is characterized by increased proliferation and activation of antigen presenting cells (histiocytes) in bone marrow and other organs of the reticuloendothelial system as well as CD8+ T cells that threatens life of patients. The predominant clinical manifestations such as fever, cytopenia, hepatitis, coagulopathy, neurological symptoms and multiple organ failure are related to systemic inflammation. We report the case of an infant who started with jaundice, abdominal pain, vomiting and malaise, at admission, hepatomegaly, splenomegaly and biochemically with features suggestive of hepatocellular inflammation and progressive cholestasis with poor outcome, it was added persistent fever, seizures, anemia, thrombocytopenia, leukopenia, elevated ferritin and hypertriglyceridemia integrating hemophagocytic syndrome with fatal outcome despite immunosuppressive therapy. |
| first_indexed | 2024-03-12T07:25:26Z |
| format | Article |
| id | doaj.art-a9ec5565684f4e0c85cdca56685de87d |
| institution | Directory Open Access Journal |
| issn | 0002-5151 2448-9190 |
| language | English |
| last_indexed | 2024-03-12T07:25:26Z |
| publishDate | 2016-03-01 |
| publisher | Colegio Mexicano de Inmunología Clínica y Alergia, A.C. |
| record_format | Article |
| series | Revista Alergia México |
| spelling | doaj.art-a9ec5565684f4e0c85cdca56685de87d2023-09-02T22:10:57ZengColegio Mexicano de Inmunología Clínica y Alergia, A.C.Revista Alergia México0002-51512448-91902016-03-01631919410.29262/ram.v63i1.133109Hemophagocytic syndrome associated to hepatitisEunice Sandoval-Ramírez0Ignacio Camacho-Meza1Nery Eduardo-Solís2Oswaldo Plascencia-Tabares3Efraín Navarro-Olivos4Francisco Ignacio Ortiz-Aldana5Instituto Mexicano del Seguro Social, Hospital de Especialidades Pediátrico, Servicio de Alergia e Inmunología Clínica Pediátrica, León, GuanajuatoInstituto Mexicano del Seguro Social, Hospital de Especialidades Pediátrico, Servicio de Alergia e Inmunología Clínica Pediátrica, León, GuanajuatoInstituto Mexicano del Seguro Social, Hospital de Especialidades Pediátrico, Servicio de Alergia e Inmunología Clínica Pediátrica, León, GuanajuatoInstituto Mexicano del Seguro Social, Hospital de Especialidades Pediátrico, León, GuanajuatoSecretaría de Salud, Instituto de Salud Pública del Estado de Guanajuato, GuanajuatoSecretaría de Salud, Instituto de Salud Pública del Estado de Guanajuato, GuanajuatoHemophagocytic syndrome is characterized by increased proliferation and activation of antigen presenting cells (histiocytes) in bone marrow and other organs of the reticuloendothelial system as well as CD8+ T cells that threatens life of patients. The predominant clinical manifestations such as fever, cytopenia, hepatitis, coagulopathy, neurological symptoms and multiple organ failure are related to systemic inflammation. We report the case of an infant who started with jaundice, abdominal pain, vomiting and malaise, at admission, hepatomegaly, splenomegaly and biochemically with features suggestive of hepatocellular inflammation and progressive cholestasis with poor outcome, it was added persistent fever, seizures, anemia, thrombocytopenia, leukopenia, elevated ferritin and hypertriglyceridemia integrating hemophagocytic syndrome with fatal outcome despite immunosuppressive therapy.http://revistaalergia.mx/ojs/index.php/ram/article/view/133síndromehemofagocitosishepatitiscitocinasmacrófago |
| spellingShingle | Eunice Sandoval-Ramírez Ignacio Camacho-Meza Nery Eduardo-Solís Oswaldo Plascencia-Tabares Efraín Navarro-Olivos Francisco Ignacio Ortiz-Aldana Hemophagocytic syndrome associated to hepatitis Revista Alergia México síndrome hemofagocitosis hepatitis citocinas macrófago |
| title | Hemophagocytic syndrome associated to hepatitis |
| title_full | Hemophagocytic syndrome associated to hepatitis |
| title_fullStr | Hemophagocytic syndrome associated to hepatitis |
| title_full_unstemmed | Hemophagocytic syndrome associated to hepatitis |
| title_short | Hemophagocytic syndrome associated to hepatitis |
| title_sort | hemophagocytic syndrome associated to hepatitis |
| topic | síndrome hemofagocitosis hepatitis citocinas macrófago |
| url | http://revistaalergia.mx/ojs/index.php/ram/article/view/133 |
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