Common polymorphisms in <it>GSTM1, GSTT1, GSTP1, GSTA1</it> and susceptibility to colorectal cancer in the Central European population
<p>Abstract</p> <p>Background</p> <p>Central Europe presents with the highest incidence of sporadic colorectal cancer (CRC) worldwide. As sporadic CRC represents a typical multifactorial disease, it is characterized by intense interaction of the genetic background with...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-06-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | http://www.eurjmedres.com/content/17/1/17 |
| _version_ | 1818234448180674560 |
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| author | Hezova Renata Bienertova-Vasku Julie Sachlova Milana Brezkova Veronika Vasku Anna Svoboda Marek Radová Lenka Kiss Igor Vyzula Rostislav Slaby Ondrej |
| author_facet | Hezova Renata Bienertova-Vasku Julie Sachlova Milana Brezkova Veronika Vasku Anna Svoboda Marek Radová Lenka Kiss Igor Vyzula Rostislav Slaby Ondrej |
| author_sort | Hezova Renata |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Central Europe presents with the highest incidence of sporadic colorectal cancer (CRC) worldwide. As sporadic CRC represents a typical multifactorial disease, it is characterized by intense interaction of the genetic background with the environment. Glutathione S-transferases could act as attractive susceptibility genes for CRC, as they are directly involved in conjugation between glutathione and chemotherapeutics, environmental pollutants and a wide spectrum of xenobiotics.</p> <p>Methods</p> <p>In this study, we investigated associations of polymorphisms in glutathione S-transferases (<it>GSTs</it>) genes, that is <it>GSTA1</it>, <it>GSTT1</it>, <it>GSTM1</it> and <it>GSTP1</it>, with CRC in a total of 197 cases and 218 controls originating from the Czech Central European population. Polymorphisms were assessed by polymerase chain reaction/restriction fragment length polymorphism-based methods, allele-specific multiplex and allelic discrimination by real-time polymerase chain reaction.</p> <p>Results</p> <p>None of investigated polymorphisms showed any associations with CRC, with the exception of <it>GSTP1;</it> where the heterozygote genotype Ile105Val was associated with decreased risk of CRC (<it>P</it> = 0.043).</p> <p>Conclusions</p> <p>The frequencies observed in our study are in accordance with those from other European Caucasian populations. Based on our studies, examined variability in <it>GST</it> genes is not a major determinant of CRC susceptibility in the Central European population.</p> |
| first_indexed | 2024-12-12T11:38:14Z |
| format | Article |
| id | doaj.art-a9ed6d7b7f594a8298ea34209008093e |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-12-12T11:38:14Z |
| publishDate | 2012-06-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-a9ed6d7b7f594a8298ea34209008093e2022-12-22T00:25:36ZengBMCEuropean Journal of Medical Research2047-783X2012-06-011711710.1186/2047-783X-17-17Common polymorphisms in <it>GSTM1, GSTT1, GSTP1, GSTA1</it> and susceptibility to colorectal cancer in the Central European populationHezova RenataBienertova-Vasku JulieSachlova MilanaBrezkova VeronikaVasku AnnaSvoboda MarekRadová LenkaKiss IgorVyzula RostislavSlaby Ondrej<p>Abstract</p> <p>Background</p> <p>Central Europe presents with the highest incidence of sporadic colorectal cancer (CRC) worldwide. As sporadic CRC represents a typical multifactorial disease, it is characterized by intense interaction of the genetic background with the environment. Glutathione S-transferases could act as attractive susceptibility genes for CRC, as they are directly involved in conjugation between glutathione and chemotherapeutics, environmental pollutants and a wide spectrum of xenobiotics.</p> <p>Methods</p> <p>In this study, we investigated associations of polymorphisms in glutathione S-transferases (<it>GSTs</it>) genes, that is <it>GSTA1</it>, <it>GSTT1</it>, <it>GSTM1</it> and <it>GSTP1</it>, with CRC in a total of 197 cases and 218 controls originating from the Czech Central European population. Polymorphisms were assessed by polymerase chain reaction/restriction fragment length polymorphism-based methods, allele-specific multiplex and allelic discrimination by real-time polymerase chain reaction.</p> <p>Results</p> <p>None of investigated polymorphisms showed any associations with CRC, with the exception of <it>GSTP1;</it> where the heterozygote genotype Ile105Val was associated with decreased risk of CRC (<it>P</it> = 0.043).</p> <p>Conclusions</p> <p>The frequencies observed in our study are in accordance with those from other European Caucasian populations. Based on our studies, examined variability in <it>GST</it> genes is not a major determinant of CRC susceptibility in the Central European population.</p>http://www.eurjmedres.com/content/17/1/17Colorectal cancer<it>GSTA1</it><it>GSTT1</it><it>GSTM1</it><it>GSTP1</it>Polymorphism |
| spellingShingle | Hezova Renata Bienertova-Vasku Julie Sachlova Milana Brezkova Veronika Vasku Anna Svoboda Marek Radová Lenka Kiss Igor Vyzula Rostislav Slaby Ondrej Common polymorphisms in <it>GSTM1, GSTT1, GSTP1, GSTA1</it> and susceptibility to colorectal cancer in the Central European population European Journal of Medical Research Colorectal cancer <it>GSTA1</it> <it>GSTT1</it> <it>GSTM1</it> <it>GSTP1</it> Polymorphism |
| title | Common polymorphisms in <it>GSTM1, GSTT1, GSTP1, GSTA1</it> and susceptibility to colorectal cancer in the Central European population |
| title_full | Common polymorphisms in <it>GSTM1, GSTT1, GSTP1, GSTA1</it> and susceptibility to colorectal cancer in the Central European population |
| title_fullStr | Common polymorphisms in <it>GSTM1, GSTT1, GSTP1, GSTA1</it> and susceptibility to colorectal cancer in the Central European population |
| title_full_unstemmed | Common polymorphisms in <it>GSTM1, GSTT1, GSTP1, GSTA1</it> and susceptibility to colorectal cancer in the Central European population |
| title_short | Common polymorphisms in <it>GSTM1, GSTT1, GSTP1, GSTA1</it> and susceptibility to colorectal cancer in the Central European population |
| title_sort | common polymorphisms in it gstm1 gstt1 gstp1 gsta1 it and susceptibility to colorectal cancer in the central european population |
| topic | Colorectal cancer <it>GSTA1</it> <it>GSTT1</it> <it>GSTM1</it> <it>GSTP1</it> Polymorphism |
| url | http://www.eurjmedres.com/content/17/1/17 |
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