The clinical effective dose of alfentanil for suppressing cough during emergence from desflurane anesthesia
BackgroundThe administration of short-acting opioids before emergence is useful for preventing emergence cough induced by an endotracheal tube. This study examined the clinically effective dose of alfentanil for suppressing cough during emergence from desflurane anesthesia.MethodsTwenty-nine adult p...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Anesthesiologists
2011-10-01
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| Series: | Korean Journal of Anesthesiology |
| Subjects: | |
| Online Access: | http://ekja.org/upload/pdf/kjae-61-292.pdf |
| _version_ | 1819092686411399168 |
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| author | Mi Geum Lee Young Jin Chang Jong Min Park Hee-Yeon Park |
| author_facet | Mi Geum Lee Young Jin Chang Jong Min Park Hee-Yeon Park |
| author_sort | Mi Geum Lee |
| collection | DOAJ |
| description | BackgroundThe administration of short-acting opioids before emergence is useful for preventing emergence cough induced by an endotracheal tube. This study examined the clinically effective dose of alfentanil for suppressing cough during emergence from desflurane anesthesia.MethodsTwenty-nine adult patients undergoing elective oral surgery were enrolled in this study. During emergence from anesthesia, the patients received alfentanil diluted in 10 ml normal saline when the end-tidal vol% of desflurane decreased to 3%. The initial alfentanil dose was 16 µg/kg. The alfentanil dose for consecutive patients, determined by Dixon's up-and-down method, increased or decreased by 2 µg/kg according to a previous patient's result.ResultsThe 50% effective dose (ED50) of alfentanil for suppressing cough during emergence from desflurane anaesthesia was 9.3 ± 1.5 µg/kg according to Dixon's up-and-down method. Isotonic regression revealed an ED50 and ED95 (95% confidence interval) of alfentanil 10.0 µg/kg (6.8-13.2 µg/kg) and 14.0 µg/kg (7.7-19.4 µg/kg), respectively.ConclusionsThe ED95 of alfentanil for suppressing emergence cough was 14.0 µg/kg. A single bolus administration of alfentanil during emergence from anesthesia was useful for suppressing emergence cough. |
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| format | Article |
| id | doaj.art-a9ed996777aa4b10abe5b0e142273b41 |
| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-21T22:59:34Z |
| publishDate | 2011-10-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-a9ed996777aa4b10abe5b0e142273b412022-12-21T18:47:21ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632011-10-0161429229610.4097/kjae.2011.61.4.2927200The clinical effective dose of alfentanil for suppressing cough during emergence from desflurane anesthesiaMi Geum Lee0Young Jin Chang1Jong Min Park2Hee-Yeon Park3Department of Anesthesiology and Pain Medicine, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea.Department of Anesthesiology and Pain Medicine, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea.Department of Anesthesiology and Pain Medicine, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea.Department of Anesthesiology and Pain Medicine, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea.BackgroundThe administration of short-acting opioids before emergence is useful for preventing emergence cough induced by an endotracheal tube. This study examined the clinically effective dose of alfentanil for suppressing cough during emergence from desflurane anesthesia.MethodsTwenty-nine adult patients undergoing elective oral surgery were enrolled in this study. During emergence from anesthesia, the patients received alfentanil diluted in 10 ml normal saline when the end-tidal vol% of desflurane decreased to 3%. The initial alfentanil dose was 16 µg/kg. The alfentanil dose for consecutive patients, determined by Dixon's up-and-down method, increased or decreased by 2 µg/kg according to a previous patient's result.ResultsThe 50% effective dose (ED50) of alfentanil for suppressing cough during emergence from desflurane anaesthesia was 9.3 ± 1.5 µg/kg according to Dixon's up-and-down method. Isotonic regression revealed an ED50 and ED95 (95% confidence interval) of alfentanil 10.0 µg/kg (6.8-13.2 µg/kg) and 14.0 µg/kg (7.7-19.4 µg/kg), respectively.ConclusionsThe ED95 of alfentanil for suppressing emergence cough was 14.0 µg/kg. A single bolus administration of alfentanil during emergence from anesthesia was useful for suppressing emergence cough.http://ekja.org/upload/pdf/kjae-61-292.pdfalfentanildixon's up-and-down methodemergence cough |
| spellingShingle | Mi Geum Lee Young Jin Chang Jong Min Park Hee-Yeon Park The clinical effective dose of alfentanil for suppressing cough during emergence from desflurane anesthesia Korean Journal of Anesthesiology alfentanil dixon's up-and-down method emergence cough |
| title | The clinical effective dose of alfentanil for suppressing cough during emergence from desflurane anesthesia |
| title_full | The clinical effective dose of alfentanil for suppressing cough during emergence from desflurane anesthesia |
| title_fullStr | The clinical effective dose of alfentanil for suppressing cough during emergence from desflurane anesthesia |
| title_full_unstemmed | The clinical effective dose of alfentanil for suppressing cough during emergence from desflurane anesthesia |
| title_short | The clinical effective dose of alfentanil for suppressing cough during emergence from desflurane anesthesia |
| title_sort | clinical effective dose of alfentanil for suppressing cough during emergence from desflurane anesthesia |
| topic | alfentanil dixon's up-and-down method emergence cough |
| url | http://ekja.org/upload/pdf/kjae-61-292.pdf |
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