Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial
The phenolic profiles of extra virgin olive oils (EVOOs) may influence their cardiovascular benefits. In a randomized crossover of acute EVOO intake on platelet function, participants (n = 9) consumed 40 mL of EVOO weekly. EVOOs were matched for total phenolic content and were either tyrosol-poor wi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-09-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617303638 |
| _version_ | 1823959236531453952 |
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| author | Karan Agrawal Eleni Melliou Xueqi Li Theresa L. Pedersen Selina C. Wang Prokopios Magiatis John W. Newman Roberta R. Holt |
| author_facet | Karan Agrawal Eleni Melliou Xueqi Li Theresa L. Pedersen Selina C. Wang Prokopios Magiatis John W. Newman Roberta R. Holt |
| author_sort | Karan Agrawal |
| collection | DOAJ |
| description | The phenolic profiles of extra virgin olive oils (EVOOs) may influence their cardiovascular benefits. In a randomized crossover of acute EVOO intake on platelet function, participants (n = 9) consumed 40 mL of EVOO weekly. EVOOs were matched for total phenolic content and were either tyrosol-poor with 1:2 oleacein/oleocanthal (D2i0.5), or 2:1 oleacein/oleocanthal (D2i2), or predominantly tyrosol (D2i0). Ibuprofen provided a platelet inhibition control. Blood was collected pre- and 2 h post-EVOO intake. D2i0.5 and D2i2 reduced 1 µg/mL collagen-stimulated maximum platelet aggregation (Pmax), with effects best correlated to oleocanthal intake (R = 0.56, P = 0.002). Total phenolic intake was independently correlated to eicosanoid production inhibition, suggesting that cyclooxygenase blockade was not responsible for the Pmax inhibition. Five participants exhibited >25% ΔPmax declines with D2i0.5 and D2i2 intake and plasma metabolomic profiles discriminated subjects by oil responsivity. Platelet responses to acute EVOO intake are associated with oil phenolic composition and may be influenced by diet. |
| first_indexed | 2024-12-17T16:30:11Z |
| format | Article |
| id | doaj.art-a9eda1a29a314fb6b7497b78e92a1e3e |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T16:30:11Z |
| publishDate | 2017-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-a9eda1a29a314fb6b7497b78e92a1e3e2022-12-21T21:41:15ZengElsevierJournal of Functional Foods1756-46462017-09-01368493Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trialKaran Agrawal0Eleni Melliou1Xueqi Li2Theresa L. Pedersen3Selina C. Wang4Prokopios Magiatis5John W. Newman6Roberta R. Holt7Department of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA; West Coast Metabolomics Center, Genome Center, 451 Health Sciences Drive, Davis, CA 95616, USADepartment of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis Zografou 15 771, Athens, GreeceUC Davis Olive Center, University of California-Davis, 392 Old Davis Road, Davis, CA 95616, USAObesity and Metabolism Research Unit, USDA – Agricultural Research Service – Western Human Nutrition Research Center, 430 W Health Sciences Drive, Davis, CA 95616, USAUC Davis Olive Center, University of California-Davis, 392 Old Davis Road, Davis, CA 95616, USA; Department of Food Science and Technology, University of California-Davis, One Shields Avenue, Davis, CA 95616, USADepartment of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis Zografou 15 771, Athens, GreeceDepartment of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA; West Coast Metabolomics Center, Genome Center, 451 Health Sciences Drive, Davis, CA 95616, USA; Obesity and Metabolism Research Unit, USDA – Agricultural Research Service – Western Human Nutrition Research Center, 430 W Health Sciences Drive, Davis, CA 95616, USA; Corresponding author at: 430 W Health Sciences Drive, Davis, CA 95616, USA.Department of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USAThe phenolic profiles of extra virgin olive oils (EVOOs) may influence their cardiovascular benefits. In a randomized crossover of acute EVOO intake on platelet function, participants (n = 9) consumed 40 mL of EVOO weekly. EVOOs were matched for total phenolic content and were either tyrosol-poor with 1:2 oleacein/oleocanthal (D2i0.5), or 2:1 oleacein/oleocanthal (D2i2), or predominantly tyrosol (D2i0). Ibuprofen provided a platelet inhibition control. Blood was collected pre- and 2 h post-EVOO intake. D2i0.5 and D2i2 reduced 1 µg/mL collagen-stimulated maximum platelet aggregation (Pmax), with effects best correlated to oleocanthal intake (R = 0.56, P = 0.002). Total phenolic intake was independently correlated to eicosanoid production inhibition, suggesting that cyclooxygenase blockade was not responsible for the Pmax inhibition. Five participants exhibited >25% ΔPmax declines with D2i0.5 and D2i2 intake and plasma metabolomic profiles discriminated subjects by oil responsivity. Platelet responses to acute EVOO intake are associated with oil phenolic composition and may be influenced by diet.http://www.sciencedirect.com/science/article/pii/S1756464617303638Platelet aggregationHumanExtra virgin olive oilOleocanthalOxylipins |
| spellingShingle | Karan Agrawal Eleni Melliou Xueqi Li Theresa L. Pedersen Selina C. Wang Prokopios Magiatis John W. Newman Roberta R. Holt Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial Journal of Functional Foods Platelet aggregation Human Extra virgin olive oil Oleocanthal Oxylipins |
| title | Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial |
| title_full | Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial |
| title_fullStr | Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial |
| title_full_unstemmed | Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial |
| title_short | Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial |
| title_sort | oleocanthal rich extra virgin olive oil demonstrates acute anti platelet effects in healthy men in a randomized trial |
| topic | Platelet aggregation Human Extra virgin olive oil Oleocanthal Oxylipins |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617303638 |
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