Development of core-shell magnetic molecularly imprinted polymer-based electrochemical sensor for sensitive and selective detection of ezetimibe
A sensitive electrochemical molecularly imprinted polymer (MIP) sensor was fabricated for detection of ezetimibe (Eze) as an effective cholesterol absorption inhibitor on the surface of a screen-printed carbon electrode based on a magnetic nanoparticle decorated with MIP (Fe3O4@MIP). Placing the mag...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023043773 |
| _version_ | 1797806391041196032 |
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| author | Ayemeh Bagheri Hashkavayi Abdolhossein Alizadeh Razieh Azimi Moazameh Peyrovi Jahan Bakhsh Raoof Honggu Chun |
| author_facet | Ayemeh Bagheri Hashkavayi Abdolhossein Alizadeh Razieh Azimi Moazameh Peyrovi Jahan Bakhsh Raoof Honggu Chun |
| author_sort | Ayemeh Bagheri Hashkavayi |
| collection | DOAJ |
| description | A sensitive electrochemical molecularly imprinted polymer (MIP) sensor was fabricated for detection of ezetimibe (Eze) as an effective cholesterol absorption inhibitor on the surface of a screen-printed carbon electrode based on a magnetic nanoparticle decorated with MIP (Fe3O4@MIP). Placing the magnetic nanoparticle inside the MIP increases the biocompatibility, surface-to-volume ratio, and sensitivity of the sensor. Methacrylic acid (MAA) was used as a monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker, and Eze as a template. The fabricated Fe3O4@MIP was characterized using Fourier-transform infrared spectroscopy (FTIR), Transmission electron microscopy (TEM), and scanning electron microscopy (SEM). Detection of Eze was achieved by differential pulse voltammetry. Using this sensor, Eze can be sensitively detected in the range of 1.0 nM–10 μM and detection limit of 0.7 nM. In addition, we have shown that the proposed sensor successfully detects different concentrations of Eze in human serum samples and thus proves its practical application. |
| first_indexed | 2024-03-13T06:06:35Z |
| format | Article |
| id | doaj.art-a9edf4366d204ede964fb46a6d2a2ae6 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T06:06:35Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-a9edf4366d204ede964fb46a6d2a2ae62023-06-12T04:09:23ZengElsevierHeliyon2405-84402023-06-0196e17169Development of core-shell magnetic molecularly imprinted polymer-based electrochemical sensor for sensitive and selective detection of ezetimibeAyemeh Bagheri Hashkavayi0Abdolhossein Alizadeh1Razieh Azimi2Moazameh Peyrovi3Jahan Bakhsh Raoof4Honggu Chun5Department of Biomedical Engineering, Korea University, Seoul 02841, South KoreaDepartment of Chemical Industry, Bushehr Branch, Technical and Vocational University, Bushehr, IranResearch Institute of Forests and Rangelands, Agricultural Research, Education and Extension Organization (AREEO), Tehran, IranDepartment of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, IranElectroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, IranDepartment of Biomedical Engineering, Korea University, Seoul 02841, South Korea; Interdisciplinary Program in Precision Public Health, Korea University, Seoul 02841, South Korea; Corresponding author. Department of Biomedical Engineering, Korea University, Seoul 02841, South Korea.A sensitive electrochemical molecularly imprinted polymer (MIP) sensor was fabricated for detection of ezetimibe (Eze) as an effective cholesterol absorption inhibitor on the surface of a screen-printed carbon electrode based on a magnetic nanoparticle decorated with MIP (Fe3O4@MIP). Placing the magnetic nanoparticle inside the MIP increases the biocompatibility, surface-to-volume ratio, and sensitivity of the sensor. Methacrylic acid (MAA) was used as a monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker, and Eze as a template. The fabricated Fe3O4@MIP was characterized using Fourier-transform infrared spectroscopy (FTIR), Transmission electron microscopy (TEM), and scanning electron microscopy (SEM). Detection of Eze was achieved by differential pulse voltammetry. Using this sensor, Eze can be sensitively detected in the range of 1.0 nM–10 μM and detection limit of 0.7 nM. In addition, we have shown that the proposed sensor successfully detects different concentrations of Eze in human serum samples and thus proves its practical application.http://www.sciencedirect.com/science/article/pii/S2405844023043773Molecularly imprinted polymerEzetimibeElectrochemical sensorsMagnetic nanoparticlesCore-shell structure |
| spellingShingle | Ayemeh Bagheri Hashkavayi Abdolhossein Alizadeh Razieh Azimi Moazameh Peyrovi Jahan Bakhsh Raoof Honggu Chun Development of core-shell magnetic molecularly imprinted polymer-based electrochemical sensor for sensitive and selective detection of ezetimibe Heliyon Molecularly imprinted polymer Ezetimibe Electrochemical sensors Magnetic nanoparticles Core-shell structure |
| title | Development of core-shell magnetic molecularly imprinted polymer-based electrochemical sensor for sensitive and selective detection of ezetimibe |
| title_full | Development of core-shell magnetic molecularly imprinted polymer-based electrochemical sensor for sensitive and selective detection of ezetimibe |
| title_fullStr | Development of core-shell magnetic molecularly imprinted polymer-based electrochemical sensor for sensitive and selective detection of ezetimibe |
| title_full_unstemmed | Development of core-shell magnetic molecularly imprinted polymer-based electrochemical sensor for sensitive and selective detection of ezetimibe |
| title_short | Development of core-shell magnetic molecularly imprinted polymer-based electrochemical sensor for sensitive and selective detection of ezetimibe |
| title_sort | development of core shell magnetic molecularly imprinted polymer based electrochemical sensor for sensitive and selective detection of ezetimibe |
| topic | Molecularly imprinted polymer Ezetimibe Electrochemical sensors Magnetic nanoparticles Core-shell structure |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023043773 |
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