Artificial genetic polymers against human pathologies
Abstract Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these artificial hybrid polymers are now being employed in various areas of theranostic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Biology Direct |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13062-022-00353-7 |
| _version_ | 1811301897238216704 |
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| author | Gleb S. Ivanov Vyacheslav G. Tribulovich Nikolay B. Pestov Temitope I. David Abdul-Saleem Amoah Tatyana V. Korneenko Nikolai A. Barlev |
| author_facet | Gleb S. Ivanov Vyacheslav G. Tribulovich Nikolay B. Pestov Temitope I. David Abdul-Saleem Amoah Tatyana V. Korneenko Nikolai A. Barlev |
| author_sort | Gleb S. Ivanov |
| collection | DOAJ |
| description | Abstract Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these artificial hybrid polymers are now being employed in various areas of theranostics (therapy and diagnostics). The current review provides an overview of their structure, principles of rational design, and biophysical features as well as highlights the areas of their successful implementation in biology and biomedicine. Finally, the review discusses the areas of improvement that would allow their use as a new class of therapeutics in the future. |
| first_indexed | 2024-04-13T07:17:03Z |
| format | Article |
| id | doaj.art-a9ee53a3af80442ba86a886ad8ba03b3 |
| institution | Directory Open Access Journal |
| issn | 1745-6150 |
| language | English |
| last_indexed | 2024-04-13T07:17:03Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology Direct |
| spelling | doaj.art-a9ee53a3af80442ba86a886ad8ba03b32022-12-22T02:56:43ZengBMCBiology Direct1745-61502022-12-0117112110.1186/s13062-022-00353-7Artificial genetic polymers against human pathologiesGleb S. Ivanov0Vyacheslav G. Tribulovich1Nikolay B. Pestov2Temitope I. David3Abdul-Saleem Amoah4Tatyana V. Korneenko5Nikolai A. Barlev6Institute of CytologySt. Petersburg State Technological Institute (Technical University)Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological ProductsPhystech School of Biological and Medical Physics, Moscow Institute of Physics and TechnologyPhystech School of Biological and Medical Physics, Moscow Institute of Physics and TechnologyShemyakin-Ovchinnikov Institute of Bioorganic ChemistryInstitute of CytologyAbstract Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these artificial hybrid polymers are now being employed in various areas of theranostics (therapy and diagnostics). The current review provides an overview of their structure, principles of rational design, and biophysical features as well as highlights the areas of their successful implementation in biology and biomedicine. Finally, the review discusses the areas of improvement that would allow their use as a new class of therapeutics in the future.https://doi.org/10.1186/s13062-022-00353-7Locked nucleic acidsPeptide nucleic acidsXenonucleic acids |
| spellingShingle | Gleb S. Ivanov Vyacheslav G. Tribulovich Nikolay B. Pestov Temitope I. David Abdul-Saleem Amoah Tatyana V. Korneenko Nikolai A. Barlev Artificial genetic polymers against human pathologies Biology Direct Locked nucleic acids Peptide nucleic acids Xenonucleic acids |
| title | Artificial genetic polymers against human pathologies |
| title_full | Artificial genetic polymers against human pathologies |
| title_fullStr | Artificial genetic polymers against human pathologies |
| title_full_unstemmed | Artificial genetic polymers against human pathologies |
| title_short | Artificial genetic polymers against human pathologies |
| title_sort | artificial genetic polymers against human pathologies |
| topic | Locked nucleic acids Peptide nucleic acids Xenonucleic acids |
| url | https://doi.org/10.1186/s13062-022-00353-7 |
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