Stromal Senescence following Treatment with the CDK4/6 Inhibitor Palbociclib Alters the Lung Metastatic Niche and Increases Metastasis of Drug-Resistant Mammary Cancer Cells

Stromal Senescence following Treatment with the CDK4/6 Inhibitor Palbociclib Alters the Lung Metastatic Niche and Increases Metastasis of Drug-Resistant Mammary Cancer Cells

Background: CDK4/6 inhibitors (CDKi) have improved disease control in hormone-receptor-positive, HER2-negative metastatic breast cancer, but most patients develop progressive disease. Methods: We asked whether host stromal senescence after CDK4/6 inhibition affects metastatic seeding and growth of C...

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Bibliographic Details
Main Authors: Gregory T. Gallanis, Ghada M. Sharif, Marcel O. Schmidt, Benjamin N. Friedland, Rohith Battina, Raneen Rahhal, John E. Davis, Irfan S. Khan, Anton Wellstein, Anna T. Riegel
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cancers
Subjects:
CDK4/6 inhibitors
palbociclib
abemaciclib
lung metastasis
mammary cancer
senescence
Online Access:https://www.mdpi.com/2072-6694/15/6/1908

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https://www.mdpi.com/2072-6694/15/6/1908

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