Stromal Senescence following Treatment with the CDK4/6 Inhibitor Palbociclib Alters the Lung Metastatic Niche and Increases Metastasis of Drug-Resistant Mammary Cancer Cells
Background: CDK4/6 inhibitors (CDKi) have improved disease control in hormone-receptor-positive, HER2-negative metastatic breast cancer, but most patients develop progressive disease. Methods: We asked whether host stromal senescence after CDK4/6 inhibition affects metastatic seeding and growth of C...
Main Authors: | Gregory T. Gallanis, Ghada M. Sharif, Marcel O. Schmidt, Benjamin N. Friedland, Rohith Battina, Raneen Rahhal, John E. Davis, Irfan S. Khan, Anton Wellstein, Anna T. Riegel |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-03-01
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Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/15/6/1908 |
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