Clinical polyneuropathy does not increase with prediabetes or metabolic syndrome in the Japanese general population
Abstract Aims/Introduction The prevalence of clinical polyneuropathies (ClinPNs) or nerve conduction abnormality (NCA) in the groups stratified by glucose tolerance, individual components of metabolic syndrome (metabolic syndrome [MetS] components: hypertension, dyslipidemia, obesity) and MetS defin...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-11-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13058 |
| _version_ | 1818573673823469568 |
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| author | Seigo Kurisu Hideyuki Sasaki Shohei Kishimoto Kazuhiro Hirayasu Kinichi Ogawa Shohei Matsuno Hiroto Furuta Mikio Arita Keigo Naka Kishio Nanjo Takashi Akamizu |
| author_facet | Seigo Kurisu Hideyuki Sasaki Shohei Kishimoto Kazuhiro Hirayasu Kinichi Ogawa Shohei Matsuno Hiroto Furuta Mikio Arita Keigo Naka Kishio Nanjo Takashi Akamizu |
| author_sort | Seigo Kurisu |
| collection | DOAJ |
| description | Abstract Aims/Introduction The prevalence of clinical polyneuropathies (ClinPNs) or nerve conduction abnormality (NCA) in the groups stratified by glucose tolerance, individual components of metabolic syndrome (metabolic syndrome [MetS] components: hypertension, dyslipidemia, obesity) and MetS defined by the International Diabetes Federation consensus was investigated in the Japanese general population. Factors associated with ClinPN and NCA were also identified. Materials and Methods A total of 625 examinees of regional medical checkup programs were recruited to this cross‐sectional study. ClinPNs were diagnosed by the Toronto Consensus. NCA was judged by at least one bilateral abnormality of sural nerve action potential amplitude or conduction velocity measured by a point‐of‐care nerve conduction device (DPNCheck). Clinical factors associated with ClinPNs or NCA were examined by multiple logistic regression analysis. Deteriorating factors of sural nerve action potential amplitude or conduction velocity values were also investigated in participants without diabetes (n = 550). Results As for glucose tolerance, ClinPNs or NCA significantly increased only in known diabetes patients compared with other groups. There was no difference between prediabetes and the normal group. The prevalence of ClinPNs and NCA was not significantly related to MetS or MetS’ components, except for frequent NCA in obesity. The factors significantly associated with both NCA and ClinPNs were smoking and known diabetes. In non‐diabetic participants, aging, tall height and hypertension were significant deteriorating factors of nerve conduction functions. Conclusions In Japan, ClinPNs and NCA were increased in known diabetes patients, but did not increase in participants with prediabetes, MetS and MetS’ components. Smoking and known diabetes were factors significantly associated with ClinPNs or NCA. Hypertension might be a modifiable deteriorating factor of nerve function. |
| first_indexed | 2024-12-15T00:14:49Z |
| format | Article |
| id | doaj.art-a9f0e869a77f461bb5967b52ceaf5bcf |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-12-15T00:14:49Z |
| publishDate | 2019-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-a9f0e869a77f461bb5967b52ceaf5bcf2022-12-21T22:42:29ZengWileyJournal of Diabetes Investigation2040-11162040-11242019-11-011061565157510.1111/jdi.13058Clinical polyneuropathy does not increase with prediabetes or metabolic syndrome in the Japanese general populationSeigo Kurisu0Hideyuki Sasaki1Shohei Kishimoto2Kazuhiro Hirayasu3Kinichi Ogawa4Shohei Matsuno5Hiroto Furuta6Mikio Arita7Keigo Naka8Kishio Nanjo9Takashi Akamizu10Department of Medicine Kihoku HospitalWakayama Medical UniversityWakayamaJapanDivision of Diabetes and Metabolism Satellite Clinic for Integrative and Anti‐Aging Medicine Wakayama Medical University WakayamaJapanFirst Department of Medicine Wakayama Medical University Wakayama JapanDepartment of Medicine Kihoku HospitalWakayama Medical UniversityWakayamaJapanKansai University of Health Sciences Osaka JapanFirst Department of Medicine Wakayama Medical University Wakayama JapanFirst Department of Medicine Wakayama Medical University Wakayama JapanHealth‐promotion Research Center Wakayama JapanWakayama Rosai Hospital WakayamaJapanWakayama Rosai Hospital WakayamaJapanFirst Department of Medicine Wakayama Medical University Wakayama JapanAbstract Aims/Introduction The prevalence of clinical polyneuropathies (ClinPNs) or nerve conduction abnormality (NCA) in the groups stratified by glucose tolerance, individual components of metabolic syndrome (metabolic syndrome [MetS] components: hypertension, dyslipidemia, obesity) and MetS defined by the International Diabetes Federation consensus was investigated in the Japanese general population. Factors associated with ClinPN and NCA were also identified. Materials and Methods A total of 625 examinees of regional medical checkup programs were recruited to this cross‐sectional study. ClinPNs were diagnosed by the Toronto Consensus. NCA was judged by at least one bilateral abnormality of sural nerve action potential amplitude or conduction velocity measured by a point‐of‐care nerve conduction device (DPNCheck). Clinical factors associated with ClinPNs or NCA were examined by multiple logistic regression analysis. Deteriorating factors of sural nerve action potential amplitude or conduction velocity values were also investigated in participants without diabetes (n = 550). Results As for glucose tolerance, ClinPNs or NCA significantly increased only in known diabetes patients compared with other groups. There was no difference between prediabetes and the normal group. The prevalence of ClinPNs and NCA was not significantly related to MetS or MetS’ components, except for frequent NCA in obesity. The factors significantly associated with both NCA and ClinPNs were smoking and known diabetes. In non‐diabetic participants, aging, tall height and hypertension were significant deteriorating factors of nerve conduction functions. Conclusions In Japan, ClinPNs and NCA were increased in known diabetes patients, but did not increase in participants with prediabetes, MetS and MetS’ components. Smoking and known diabetes were factors significantly associated with ClinPNs or NCA. Hypertension might be a modifiable deteriorating factor of nerve function.https://doi.org/10.1111/jdi.13058Metabolic syndromePrediabetesPrevalence of symmetric sensorimotor polyneuropathy |
| spellingShingle | Seigo Kurisu Hideyuki Sasaki Shohei Kishimoto Kazuhiro Hirayasu Kinichi Ogawa Shohei Matsuno Hiroto Furuta Mikio Arita Keigo Naka Kishio Nanjo Takashi Akamizu Clinical polyneuropathy does not increase with prediabetes or metabolic syndrome in the Japanese general population Journal of Diabetes Investigation Metabolic syndrome Prediabetes Prevalence of symmetric sensorimotor polyneuropathy |
| title | Clinical polyneuropathy does not increase with prediabetes or metabolic syndrome in the Japanese general population |
| title_full | Clinical polyneuropathy does not increase with prediabetes or metabolic syndrome in the Japanese general population |
| title_fullStr | Clinical polyneuropathy does not increase with prediabetes or metabolic syndrome in the Japanese general population |
| title_full_unstemmed | Clinical polyneuropathy does not increase with prediabetes or metabolic syndrome in the Japanese general population |
| title_short | Clinical polyneuropathy does not increase with prediabetes or metabolic syndrome in the Japanese general population |
| title_sort | clinical polyneuropathy does not increase with prediabetes or metabolic syndrome in the japanese general population |
| topic | Metabolic syndrome Prediabetes Prevalence of symmetric sensorimotor polyneuropathy |
| url | https://doi.org/10.1111/jdi.13058 |
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