Evaluation of the Pharmacokinetics of the Pancreastatin Inhibitor PSTi8 Peptide in Rats: Integration of In Vitro and In Vivo Findings

Evaluation of the Pharmacokinetics of the Pancreastatin Inhibitor PSTi8 Peptide in Rats: Integration of In Vitro and In Vivo Findings

PSTi8 is a pancreastatin inhibitory peptide that is effective in the treatment of diabetic models. This study investigates the pharmacokinetic (PK) properties of PSTi8 in Sprague Dawley rats, for the first time. In vitro and in vivo PK studies were performed to evaluate the solubility, stability in...

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Bibliographic Details
Main Authors: Guru R. Valicherla, Roshan A. Katekar, Shailesh Dadge, Mohammed Riyazuddin, Anees A. Syed, Sandeep K. Singh, Athar Husain, Muhammad Wahajuddin, Jiaur R. Gayen
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
antidiabetic drugs
PSTi8
in vitro ADME
in vivo pharmacokinetics
bioavailability
Online Access:https://www.mdpi.com/1420-3049/27/2/339

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https://www.mdpi.com/1420-3049/27/2/339

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