Combination of Clptm1L and TMEM207 Expression as a Robust Prognostic Marker in Oral Squamous Cell Carcinoma
Overexpression of Cleft Lip and Palate Transmembrane 1-Like (Clptm1L) confers cancer cell survival through the endoplasmic reticulum (ER) stress survival signaling pathway, while TMEM207 impairs the tumor suppressor function of WW domain containing oxidoreductase (WWOX), which sensitizes cancer cell...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Oral Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2021.638213/full |
| _version_ | 1831635015239204864 |
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| author | Kimika Hano Kiichi Hatano Chiemi Saigo Yusuke Kito Toshiyuki Shibata Tamotsu Takeuchi |
| author_facet | Kimika Hano Kiichi Hatano Chiemi Saigo Yusuke Kito Toshiyuki Shibata Tamotsu Takeuchi |
| author_sort | Kimika Hano |
| collection | DOAJ |
| description | Overexpression of Cleft Lip and Palate Transmembrane 1-Like (Clptm1L) confers cancer cell survival through the endoplasmic reticulum (ER) stress survival signaling pathway, while TMEM207 impairs the tumor suppressor function of WW domain containing oxidoreductase (WWOX), which sensitizes cancer cells to ER stress-induced apoptosis. In the present study, we examined whether these two ER stress-related proteins, Clptm1L and TMEM207, could be prognostic markers in oral squamous cell carcinoma (OSCC). Immunohistochemical staining using specific antibodies to Clptm1L or TMEM207 revealed that 31 of 89 tissue specimens exhibited concomitant expression of Clptm1L and TMEM207 at the cancer invasion front. A Kaplan–Meier plot of the patient survival curve followed by a log-rank test revealed that the coexpression of Clptm1L and TMEM207 was significantly associated with poor outcome in patients with OSCC (P = 0.00252). Coexpression of Clptm1L and TMEM207 was closely related to lymph node metastasis (P=0.000574). Both univariate and multivariate analyses demonstrated that coexpression of Clptm1L and TMEM207 predicted the poor prognosis of the patients with OSCC. The present study indicated that the double positive Clptm1L and TMEM207 immunoreactivity was closely related to lymph node metastasis with prognostic value in patients with OSCC. |
| first_indexed | 2024-12-19T06:05:21Z |
| format | Article |
| id | doaj.art-a9f57c8a359e4fa98e6a61f4fbc9e1d8 |
| institution | Directory Open Access Journal |
| issn | 2673-4842 |
| language | English |
| last_indexed | 2024-12-19T06:05:21Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oral Health |
| spelling | doaj.art-a9f57c8a359e4fa98e6a61f4fbc9e1d82022-12-21T20:33:10ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422021-03-01210.3389/froh.2021.638213638213Combination of Clptm1L and TMEM207 Expression as a Robust Prognostic Marker in Oral Squamous Cell CarcinomaKimika Hano0Kiichi Hatano1Chiemi Saigo2Yusuke Kito3Toshiyuki Shibata4Tamotsu Takeuchi5Department of Oral and Maxillofacial Surgery, Gifu University Graduate School of Medicine, Gifu, JapanDepartment of Oral and Maxillofacial Surgery, Gifu University Graduate School of Medicine, Gifu, JapanDepartment of Pathology and Translational Research, Gifu University Graduate School of Medicine, Gifu, JapanDepartment of Pathology and Translational Research, Gifu University Graduate School of Medicine, Gifu, JapanDepartment of Oral and Maxillofacial Surgery, Gifu University Graduate School of Medicine, Gifu, JapanDepartment of Pathology and Translational Research, Gifu University Graduate School of Medicine, Gifu, JapanOverexpression of Cleft Lip and Palate Transmembrane 1-Like (Clptm1L) confers cancer cell survival through the endoplasmic reticulum (ER) stress survival signaling pathway, while TMEM207 impairs the tumor suppressor function of WW domain containing oxidoreductase (WWOX), which sensitizes cancer cells to ER stress-induced apoptosis. In the present study, we examined whether these two ER stress-related proteins, Clptm1L and TMEM207, could be prognostic markers in oral squamous cell carcinoma (OSCC). Immunohistochemical staining using specific antibodies to Clptm1L or TMEM207 revealed that 31 of 89 tissue specimens exhibited concomitant expression of Clptm1L and TMEM207 at the cancer invasion front. A Kaplan–Meier plot of the patient survival curve followed by a log-rank test revealed that the coexpression of Clptm1L and TMEM207 was significantly associated with poor outcome in patients with OSCC (P = 0.00252). Coexpression of Clptm1L and TMEM207 was closely related to lymph node metastasis (P=0.000574). Both univariate and multivariate analyses demonstrated that coexpression of Clptm1L and TMEM207 predicted the poor prognosis of the patients with OSCC. The present study indicated that the double positive Clptm1L and TMEM207 immunoreactivity was closely related to lymph node metastasis with prognostic value in patients with OSCC.https://www.frontiersin.org/articles/10.3389/froh.2021.638213/fullOSCCprognosisTMEM207CLPTM1LER-stressWWOX |
| spellingShingle | Kimika Hano Kiichi Hatano Chiemi Saigo Yusuke Kito Toshiyuki Shibata Tamotsu Takeuchi Combination of Clptm1L and TMEM207 Expression as a Robust Prognostic Marker in Oral Squamous Cell Carcinoma Frontiers in Oral Health OSCC prognosis TMEM207 CLPTM1L ER-stress WWOX |
| title | Combination of Clptm1L and TMEM207 Expression as a Robust Prognostic Marker in Oral Squamous Cell Carcinoma |
| title_full | Combination of Clptm1L and TMEM207 Expression as a Robust Prognostic Marker in Oral Squamous Cell Carcinoma |
| title_fullStr | Combination of Clptm1L and TMEM207 Expression as a Robust Prognostic Marker in Oral Squamous Cell Carcinoma |
| title_full_unstemmed | Combination of Clptm1L and TMEM207 Expression as a Robust Prognostic Marker in Oral Squamous Cell Carcinoma |
| title_short | Combination of Clptm1L and TMEM207 Expression as a Robust Prognostic Marker in Oral Squamous Cell Carcinoma |
| title_sort | combination of clptm1l and tmem207 expression as a robust prognostic marker in oral squamous cell carcinoma |
| topic | OSCC prognosis TMEM207 CLPTM1L ER-stress WWOX |
| url | https://www.frontiersin.org/articles/10.3389/froh.2021.638213/full |
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