Expression and Potential Biomarkers of Regulators for M7G RNA Modification in Gliomas
Gliomas are the most frequent primary malignant brain tumors of the central nervous system, causing significant impairment and death. There is mounting evidence that N7 methylguanosine (m7G) RNA dysmethylation plays a significant role in the development and progression of cancer. However, the expres...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.886246/full |
| _version_ | 1817984640652148736 |
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| author | Zhen Chen Zhe Zhang Wei Ding Jie-hui Zhang Zi-long Tan Yu-ran Mei Wei He Xiao-jing Wang Xiao-jing Wang |
| author_facet | Zhen Chen Zhe Zhang Wei Ding Jie-hui Zhang Zi-long Tan Yu-ran Mei Wei He Xiao-jing Wang Xiao-jing Wang |
| author_sort | Zhen Chen |
| collection | DOAJ |
| description | Gliomas are the most frequent primary malignant brain tumors of the central nervous system, causing significant impairment and death. There is mounting evidence that N7 methylguanosine (m7G) RNA dysmethylation plays a significant role in the development and progression of cancer. However, the expression patterns and function of the m7G RNA methylation regulator in gliomas are yet unknown. The goal of this study was to examine the expression patterns of 31 critical regulators linked with m7G RNA methylation and their prognostic significance in gliomas. To begin, we systematically analyzed patient clinical and prognostic data and mRNA gene expression data from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. We found that 17 key regulators of m7G RNA methylation showed significantly higher expression levels in gliomas. We then divided the sample into two subgroups by consensus clustering. Cluster 2 had a poorer prognosis than cluster 1 and was associated with a higher histological grade. In addition, cluster 2 was significantly enriched for cancer-related pathways. Based on this discovery, we developed a risk model involving three m7G methylation regulators. Patients were divided into high-risk and low-risk groups based on risk scores. Overall survival (OS) was significantly lower in the high-risk group than in the low-risk group. Further analysis showed that the risk score was an independent prognostic factor for gliomas. |
| first_indexed | 2024-04-13T23:48:21Z |
| format | Article |
| id | doaj.art-a9f9153929dc4e60baa927705f32a820 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T23:48:21Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-a9f9153929dc4e60baa927705f32a8202022-12-22T02:24:14ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-05-011310.3389/fneur.2022.886246886246Expression and Potential Biomarkers of Regulators for M7G RNA Modification in GliomasZhen Chen0Zhe Zhang1Wei Ding2Jie-hui Zhang3Zi-long Tan4Yu-ran Mei5Wei He6Xiao-jing Wang7Xiao-jing Wang8Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaYifeng County People's Hospital, Yichun City, ChinaYifeng County People's Hospital, Yichun City, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaGliomas are the most frequent primary malignant brain tumors of the central nervous system, causing significant impairment and death. There is mounting evidence that N7 methylguanosine (m7G) RNA dysmethylation plays a significant role in the development and progression of cancer. However, the expression patterns and function of the m7G RNA methylation regulator in gliomas are yet unknown. The goal of this study was to examine the expression patterns of 31 critical regulators linked with m7G RNA methylation and their prognostic significance in gliomas. To begin, we systematically analyzed patient clinical and prognostic data and mRNA gene expression data from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. We found that 17 key regulators of m7G RNA methylation showed significantly higher expression levels in gliomas. We then divided the sample into two subgroups by consensus clustering. Cluster 2 had a poorer prognosis than cluster 1 and was associated with a higher histological grade. In addition, cluster 2 was significantly enriched for cancer-related pathways. Based on this discovery, we developed a risk model involving three m7G methylation regulators. Patients were divided into high-risk and low-risk groups based on risk scores. Overall survival (OS) was significantly lower in the high-risk group than in the low-risk group. Further analysis showed that the risk score was an independent prognostic factor for gliomas.https://www.frontiersin.org/articles/10.3389/fneur.2022.886246/fullN7-methylguanosinegliomasepigeneticsprognostic signaturebioinformatics |
| spellingShingle | Zhen Chen Zhe Zhang Wei Ding Jie-hui Zhang Zi-long Tan Yu-ran Mei Wei He Xiao-jing Wang Xiao-jing Wang Expression and Potential Biomarkers of Regulators for M7G RNA Modification in Gliomas Frontiers in Neurology N7-methylguanosine gliomas epigenetics prognostic signature bioinformatics |
| title | Expression and Potential Biomarkers of Regulators for M7G RNA Modification in Gliomas |
| title_full | Expression and Potential Biomarkers of Regulators for M7G RNA Modification in Gliomas |
| title_fullStr | Expression and Potential Biomarkers of Regulators for M7G RNA Modification in Gliomas |
| title_full_unstemmed | Expression and Potential Biomarkers of Regulators for M7G RNA Modification in Gliomas |
| title_short | Expression and Potential Biomarkers of Regulators for M7G RNA Modification in Gliomas |
| title_sort | expression and potential biomarkers of regulators for m7g rna modification in gliomas |
| topic | N7-methylguanosine gliomas epigenetics prognostic signature bioinformatics |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.886246/full |
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