Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate

Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate

Fusion of HIV-1 with the membrane of its target cell, an obligate first step in virus infectivity, is mediated by binding of the viral envelope (Env) spike protein to its receptors, CD4 and CCR5/CXCR4, on the cell surface. The process of viral fusion appears to be fast compared with viral egress and...

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Bibliographic Details
Main Authors: Mark S Ladinsky, Priyanthi NP Gnanapragasam, Zhi Yang, Anthony P West, Michael S Kay, Pamela J Bjorkman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
HIV-1
prehairpin intermediate
TZM-bl cell
electron tomography
viral fusion
Online Access:https://elifesciences.org/articles/58411

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