The effect of coating chitosan on Porphyromonas gingivalis biofilm formation in the surface of orthodontic mini-implant
Infection is the main problem for the failure of orthodontic mini-implant. Modern prevention of infection is now focused on local antibacterial coatings on implant devices. Chitosan is biocompatible and has antibacterial properties. Azithromycin is a synthetic antibiotic with immunomodulatory proper...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Advanced Pharmaceutical Technology & Research |
| Subjects: | |
| Online Access: | http://www.japtr.org/article.asp?issn=2231-4040;year=2021;volume=12;issue=1;spage=84;epage=88;aulast=Anggani |
| _version_ | 1818954237291266048 |
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| author | Haru Setyo Anggani Renaldo Guruh Perdana Erwin Siregar Endang Winiati Bachtiar |
| author_facet | Haru Setyo Anggani Renaldo Guruh Perdana Erwin Siregar Endang Winiati Bachtiar |
| author_sort | Haru Setyo Anggani |
| collection | DOAJ |
| description | Infection is the main problem for the failure of orthodontic mini-implant. Modern prevention of infection is now focused on local antibacterial coatings on implant devices. Chitosan is biocompatible and has antibacterial properties. Azithromycin is a synthetic antibiotic with immunomodulatory properties in which it has an advantage over the rest of antibiotics. This study aimed to evaluate the effect coating chitosan on the orthodontic mini-implant in Porphyromonas gingivalis biofilm formation. This is an experimental study using 25 orthodontic mini-implants. Five samples were coated with chitosan, 5 samples were coated with chitosan–azithromycin, 5 samples were coated with azithromycin, 5 samples were uncoated, and 5 samples were uncoated and were not exposed to P. gingivalis. P. gingivalis biofilms on the surface of the orthodontic mini-implant were observed after 24 h of incubation. P. gingivalis biofilm mass inhibition was highest in the azithromycin-treated group, followed by chitosan + azithromycin and chitosan only. The one-way ANOVA statistic test and post hoc Bonferroni statistic test of P. gingivalis biofilm mass show a significant difference between and within groups of experiments (P < 0.05). The Pearson correlation test with a value of R = +0.88, indicated that the bacterial viability count and the biofilm mass have a strong positive correlation. In conclusion, orthodontic mini-implant coated with chitosan, chitosan with azithromycin, or azithromycin only effectively suppressed P. gingivalis biofilm formation. |
| first_indexed | 2024-12-20T10:18:58Z |
| format | Article |
| id | doaj.art-a9f9d2a623304c62bc0d7ec9282eb36d |
| institution | Directory Open Access Journal |
| issn | 2231-4040 0976-2094 |
| language | English |
| last_indexed | 2024-12-20T10:18:58Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Advanced Pharmaceutical Technology & Research |
| spelling | doaj.art-a9f9d2a623304c62bc0d7ec9282eb36d2022-12-21T19:43:58ZengWolters Kluwer Medknow PublicationsJournal of Advanced Pharmaceutical Technology & Research2231-40400976-20942021-01-01121848810.4103/japtr.JAPTR_95_20The effect of coating chitosan on Porphyromonas gingivalis biofilm formation in the surface of orthodontic mini-implantHaru Setyo AngganiRenaldo Guruh PerdanaErwin SiregarEndang Winiati BachtiarInfection is the main problem for the failure of orthodontic mini-implant. Modern prevention of infection is now focused on local antibacterial coatings on implant devices. Chitosan is biocompatible and has antibacterial properties. Azithromycin is a synthetic antibiotic with immunomodulatory properties in which it has an advantage over the rest of antibiotics. This study aimed to evaluate the effect coating chitosan on the orthodontic mini-implant in Porphyromonas gingivalis biofilm formation. This is an experimental study using 25 orthodontic mini-implants. Five samples were coated with chitosan, 5 samples were coated with chitosan–azithromycin, 5 samples were coated with azithromycin, 5 samples were uncoated, and 5 samples were uncoated and were not exposed to P. gingivalis. P. gingivalis biofilms on the surface of the orthodontic mini-implant were observed after 24 h of incubation. P. gingivalis biofilm mass inhibition was highest in the azithromycin-treated group, followed by chitosan + azithromycin and chitosan only. The one-way ANOVA statistic test and post hoc Bonferroni statistic test of P. gingivalis biofilm mass show a significant difference between and within groups of experiments (P < 0.05). The Pearson correlation test with a value of R = +0.88, indicated that the bacterial viability count and the biofilm mass have a strong positive correlation. In conclusion, orthodontic mini-implant coated with chitosan, chitosan with azithromycin, or azithromycin only effectively suppressed P. gingivalis biofilm formation.http://www.japtr.org/article.asp?issn=2231-4040;year=2021;volume=12;issue=1;spage=84;epage=88;aulast=Angganiazithromycinbiofilmchitosancoating of orthodontic mini-implantporphyromonas gingivalis |
| spellingShingle | Haru Setyo Anggani Renaldo Guruh Perdana Erwin Siregar Endang Winiati Bachtiar The effect of coating chitosan on Porphyromonas gingivalis biofilm formation in the surface of orthodontic mini-implant Journal of Advanced Pharmaceutical Technology & Research azithromycin biofilm chitosan coating of orthodontic mini-implant porphyromonas gingivalis |
| title | The effect of coating chitosan on Porphyromonas gingivalis biofilm formation in the surface of orthodontic mini-implant |
| title_full | The effect of coating chitosan on Porphyromonas gingivalis biofilm formation in the surface of orthodontic mini-implant |
| title_fullStr | The effect of coating chitosan on Porphyromonas gingivalis biofilm formation in the surface of orthodontic mini-implant |
| title_full_unstemmed | The effect of coating chitosan on Porphyromonas gingivalis biofilm formation in the surface of orthodontic mini-implant |
| title_short | The effect of coating chitosan on Porphyromonas gingivalis biofilm formation in the surface of orthodontic mini-implant |
| title_sort | effect of coating chitosan on porphyromonas gingivalis biofilm formation in the surface of orthodontic mini implant |
| topic | azithromycin biofilm chitosan coating of orthodontic mini-implant porphyromonas gingivalis |
| url | http://www.japtr.org/article.asp?issn=2231-4040;year=2021;volume=12;issue=1;spage=84;epage=88;aulast=Anggani |
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