An Altered Skin and Gut Microbiota Are Involved in the Modulation of Itch in Atopic Dermatitis
Skin and gut microbiota play an important role in the pathogenesis of atopic dermatitis (AD). An alteration of the microbiota diversity modulates the development and course of AD, e.g., decreased microbiome diversity correlates with disease severity, particularly in lesional skin of AD. Itch is a ha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/23/3930 |
| _version_ | 1797463432772976640 |
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| author | Catharina Sagita Moniaga Mitsutoshi Tominaga Kenji Takamori |
| author_facet | Catharina Sagita Moniaga Mitsutoshi Tominaga Kenji Takamori |
| author_sort | Catharina Sagita Moniaga |
| collection | DOAJ |
| description | Skin and gut microbiota play an important role in the pathogenesis of atopic dermatitis (AD). An alteration of the microbiota diversity modulates the development and course of AD, e.g., decreased microbiome diversity correlates with disease severity, particularly in lesional skin of AD. Itch is a hallmark of AD with unsatisfying treatment until now. Recent evidence suggests a possible role of microbiota in altering itch in AD through gut–skin–brain interactions. The microbial metabolites, proinflammatory cytokines, and impaired immune response lead to a modulation of histamine-independent itch, disruption of epidermal barrier, and central sensitization of itch mechanisms. The positive impact of probiotics in alleviating itch in AD supports this hypothesis, which may lead to novel strategies for managing itchy skin in AD patients. This review summarizes the emerging findings on the correlation between an altered microbiota and gut–skin–brain axis in AD, especially in modulating itchy skin. |
| first_indexed | 2024-03-09T17:50:38Z |
| format | Article |
| id | doaj.art-a9fe0428bbe4430797ffce5993b060b6 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T17:50:38Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a9fe0428bbe4430797ffce5993b060b62023-11-24T10:46:11ZengMDPI AGCells2073-44092022-12-011123393010.3390/cells11233930An Altered Skin and Gut Microbiota Are Involved in the Modulation of Itch in Atopic DermatitisCatharina Sagita Moniaga0Mitsutoshi Tominaga1Kenji Takamori2Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba 279-0021, JapanJuntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba 279-0021, JapanJuntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba 279-0021, JapanSkin and gut microbiota play an important role in the pathogenesis of atopic dermatitis (AD). An alteration of the microbiota diversity modulates the development and course of AD, e.g., decreased microbiome diversity correlates with disease severity, particularly in lesional skin of AD. Itch is a hallmark of AD with unsatisfying treatment until now. Recent evidence suggests a possible role of microbiota in altering itch in AD through gut–skin–brain interactions. The microbial metabolites, proinflammatory cytokines, and impaired immune response lead to a modulation of histamine-independent itch, disruption of epidermal barrier, and central sensitization of itch mechanisms. The positive impact of probiotics in alleviating itch in AD supports this hypothesis, which may lead to novel strategies for managing itchy skin in AD patients. This review summarizes the emerging findings on the correlation between an altered microbiota and gut–skin–brain axis in AD, especially in modulating itchy skin.https://www.mdpi.com/2073-4409/11/23/3930skingutmicrobiotaitchatopic dermatitis |
| spellingShingle | Catharina Sagita Moniaga Mitsutoshi Tominaga Kenji Takamori An Altered Skin and Gut Microbiota Are Involved in the Modulation of Itch in Atopic Dermatitis Cells skin gut microbiota itch atopic dermatitis |
| title | An Altered Skin and Gut Microbiota Are Involved in the Modulation of Itch in Atopic Dermatitis |
| title_full | An Altered Skin and Gut Microbiota Are Involved in the Modulation of Itch in Atopic Dermatitis |
| title_fullStr | An Altered Skin and Gut Microbiota Are Involved in the Modulation of Itch in Atopic Dermatitis |
| title_full_unstemmed | An Altered Skin and Gut Microbiota Are Involved in the Modulation of Itch in Atopic Dermatitis |
| title_short | An Altered Skin and Gut Microbiota Are Involved in the Modulation of Itch in Atopic Dermatitis |
| title_sort | altered skin and gut microbiota are involved in the modulation of itch in atopic dermatitis |
| topic | skin gut microbiota itch atopic dermatitis |
| url | https://www.mdpi.com/2073-4409/11/23/3930 |
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