Cortical region-specific engraftment of embryonic stem cell-derived neural progenitor cells restores axonal sprouting to a subcortical target and achieves motor functional recovery in a mouse model of neonatal hypoxic-ischemic brain injury

Cortical region-specific engraftment of embryonic stem cell-derived neural progenitor cells restores axonal sprouting to a subcortical target and achieves motor functional recovery in a mouse model of neonatal hypoxic-ischemic brain injury

Hypoxic–ischemic encephalopathy (HIE) at birth could cause cerebral palsy, mental retardation, and epilepsy, which last throughout the individual’s lifetime. However, few restorative treatments for ischemic tissue are currently available. Cell replacement therapy offers the potential to rescue brain...

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Bibliographic Details
Main Authors: Mizuya eShinoyama, Makoto eIdeguchi, Hiroyuki eKida, Koji eKajiwara, Yoshiteru eKagawa, Yoshihiko eMaeda, Sadahiro eNomura, Michiyasu eSuzuki
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Regeneration
Transplantation
integration
Motor function
embryonic stem cell
hypoxic–ischemic encephalopathy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00128/full

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