Involvement of Inflammasome Components in Kidney Disease
Inflammasomes are multiprotein complexes with an important role in the innate immune response. Canonical activation of inflammasomes results in caspase-1 activation and maturation of cytokines interleukin-1β and -18. These cytokines can elicit their effects through receptor activation, both locally...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/2/246 |
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| author | Ana Karina Aranda-Rivera Anjali Srivastava Alfredo Cruz-Gregorio José Pedraza-Chaverri Shrikant R. Mulay Alexandra Scholze |
| author_facet | Ana Karina Aranda-Rivera Anjali Srivastava Alfredo Cruz-Gregorio José Pedraza-Chaverri Shrikant R. Mulay Alexandra Scholze |
| author_sort | Ana Karina Aranda-Rivera |
| collection | DOAJ |
| description | Inflammasomes are multiprotein complexes with an important role in the innate immune response. Canonical activation of inflammasomes results in caspase-1 activation and maturation of cytokines interleukin-1β and -18. These cytokines can elicit their effects through receptor activation, both locally within a certain tissue and systemically. Animal models of kidney diseases have shown inflammasome involvement in inflammation, pyroptosis and fibrosis. In particular, the inflammasome component nucleotide-binding domain-like receptor family pyrin domain containing 3 (NLRP3) and related canonical mechanisms have been investigated. However, it has become increasingly clear that other inflammasome components are also of importance in kidney disease. Moreover, it is becoming obvious that the range of molecular interaction partners of inflammasome components in kidney diseases is wide. This review provides insights into these current areas of research, with special emphasis on the interaction of inflammasome components and redox signalling, endoplasmic reticulum stress, and mitochondrial function. We present our findings separately for acute kidney injury and chronic kidney disease. As we strictly divided the results into preclinical and clinical data, this review enables comparison of results from those complementary research specialities. However, it also reveals that knowledge gaps exist, especially in clinical acute kidney injury inflammasome research. Furthermore, patient comorbidities and treatments seem important drivers of inflammasome component alterations in human kidney disease. |
| first_indexed | 2024-03-09T22:45:44Z |
| format | Article |
| id | doaj.art-a9ff72844a8d4d73afb2ada162ee4d32 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T22:45:44Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-a9ff72844a8d4d73afb2ada162ee4d322023-11-23T18:30:45ZengMDPI AGAntioxidants2076-39212022-01-0111224610.3390/antiox11020246Involvement of Inflammasome Components in Kidney DiseaseAna Karina Aranda-Rivera0Anjali Srivastava1Alfredo Cruz-Gregorio2José Pedraza-Chaverri3Shrikant R. Mulay4Alexandra Scholze5Laboratory F-315, Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City 04510, MexicoDivision of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, IndiaLaboratory F-315, Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City 04510, MexicoLaboratory F-315, Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City 04510, MexicoDivision of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, IndiaDepartment of Nephrology, Odense University Hospital, Odense, Denmark, and Institute of Clinical Research, University of Southern Denmark, 5000 Odense C, DenmarkInflammasomes are multiprotein complexes with an important role in the innate immune response. Canonical activation of inflammasomes results in caspase-1 activation and maturation of cytokines interleukin-1β and -18. These cytokines can elicit their effects through receptor activation, both locally within a certain tissue and systemically. Animal models of kidney diseases have shown inflammasome involvement in inflammation, pyroptosis and fibrosis. In particular, the inflammasome component nucleotide-binding domain-like receptor family pyrin domain containing 3 (NLRP3) and related canonical mechanisms have been investigated. However, it has become increasingly clear that other inflammasome components are also of importance in kidney disease. Moreover, it is becoming obvious that the range of molecular interaction partners of inflammasome components in kidney diseases is wide. This review provides insights into these current areas of research, with special emphasis on the interaction of inflammasome components and redox signalling, endoplasmic reticulum stress, and mitochondrial function. We present our findings separately for acute kidney injury and chronic kidney disease. As we strictly divided the results into preclinical and clinical data, this review enables comparison of results from those complementary research specialities. However, it also reveals that knowledge gaps exist, especially in clinical acute kidney injury inflammasome research. Furthermore, patient comorbidities and treatments seem important drivers of inflammasome component alterations in human kidney disease.https://www.mdpi.com/2076-3921/11/2/246acute kidney injurychronic kidney diseasekidney transplantationinflammasomeredox signallingendoplasmic reticulum stress |
| spellingShingle | Ana Karina Aranda-Rivera Anjali Srivastava Alfredo Cruz-Gregorio José Pedraza-Chaverri Shrikant R. Mulay Alexandra Scholze Involvement of Inflammasome Components in Kidney Disease Antioxidants acute kidney injury chronic kidney disease kidney transplantation inflammasome redox signalling endoplasmic reticulum stress |
| title | Involvement of Inflammasome Components in Kidney Disease |
| title_full | Involvement of Inflammasome Components in Kidney Disease |
| title_fullStr | Involvement of Inflammasome Components in Kidney Disease |
| title_full_unstemmed | Involvement of Inflammasome Components in Kidney Disease |
| title_short | Involvement of Inflammasome Components in Kidney Disease |
| title_sort | involvement of inflammasome components in kidney disease |
| topic | acute kidney injury chronic kidney disease kidney transplantation inflammasome redox signalling endoplasmic reticulum stress |
| url | https://www.mdpi.com/2076-3921/11/2/246 |
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