AGMO Inhibitor Reduces 3T3-L1 Adipogenesis

AGMO Inhibitor Reduces 3T3-L1 Adipogenesis

Alkylglycerol monooxygenase (AGMO) is a tetrahydrobiopterin (BH4)-dependent enzyme with major expression in the liver and white adipose tissue that cleaves alkyl ether glycerolipids. The present study describes the disclosure and biological characterization of a candidate compound (Cp6), which inhib...

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Bibliographic Details
Main Authors: Caroline Fischer, Annett Wilken-Schmitz, Victor Hernandez-Olmos, Ewgenij Proschak, Holger Stark, Ingrid Fleming, Andreas Weigert, Manuela Thurn, Martine Hofmann, Ernst R. Werner, Gerd Geisslinger, Ellen Niederberger, Katrin Watschinger, Irmgard Tegeder
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
AGMO
compound screen
enzyme activity assay
tetrahydrobiopterin
3T3-L1 mouse fibroblasts
adipocytes
Online Access:https://www.mdpi.com/2073-4409/10/5/1081

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