Coumarins of genus Ferula L. (Apiaceae Lindl.)
The biologically active coumarins from Ferula L. species of the family Apiaceae Lindl. for the period 1970 to 2022 have been reviewed. The phytochemical investigation of different parts of Ferula L., including gum resin, leaves, fruits, seeds, roots, rhizomes, and resins led to the separation of di...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
al-Farabi Kazakh National University
2023-03-01
|
| Series: | Eurasian Chemico-Technological Journal |
| Subjects: | |
| Online Access: | https://ect-journal.kz/index.php/ectj/article/view/1494 |
| _version_ | 1797803748090707968 |
|---|---|
| author | T.S. Khosnutdinova N.G. Gemejiyeva Zh.Zh. Karzhaubekova N.A. Sultanova |
| author_facet | T.S. Khosnutdinova N.G. Gemejiyeva Zh.Zh. Karzhaubekova N.A. Sultanova |
| author_sort | T.S. Khosnutdinova |
| collection | DOAJ |
| description |
The biologically active coumarins from Ferula L. species of the family Apiaceae Lindl. for the period 1970 to 2022 have been reviewed. The phytochemical investigation of different parts of Ferula L., including gum resin, leaves, fruits, seeds, roots, rhizomes, and resins led to the separation of different types of coumarins. Nearly 185 coumarins were isolated from 35 species of Ferula L. growing in different countries. Coumarins are represented mainly by umbelliferone (7-O-hydroxycoumarin) derivatives substituted in the C-7 position of aglycone, furanocoumarins and metabolites have terpene fragments, esters and glycosides. Umbelliferon is found as a taxon for the genus Ferula L. Some «unusual» metabolites have a furan fragment attached to the pyrone ring. Coumarins are of the psoralen type, containing a furan ring in the C-6 and C-7 positions of the primary skeleton. The rare coumarins with terpene fragments (hemiterpene, monoterpen, sesquiterpene) were reported. The biological activities of some extracts and individual metabolites such as antiinflammatory, cytotoxicity, antibacterial, antileishmanial, antiviral, antigenotoxic, antitumor, anticoagulant, antioxidant, antimycobacterial, inhibition a-glucosidase, antileishmanial were found.
|
| first_indexed | 2024-03-13T05:25:33Z |
| format | Article |
| id | doaj.art-aa0147ca36c94854823f849819309f5f |
| institution | Directory Open Access Journal |
| issn | 1562-3920 2522-4867 |
| language | English |
| last_indexed | 2024-03-13T05:25:33Z |
| publishDate | 2023-03-01 |
| publisher | al-Farabi Kazakh National University |
| record_format | Article |
| series | Eurasian Chemico-Technological Journal |
| spelling | doaj.art-aa0147ca36c94854823f849819309f5f2023-06-15T07:40:13Zengal-Farabi Kazakh National UniversityEurasian Chemico-Technological Journal1562-39202522-48672023-03-0125110.18321/ectj1494Coumarins of genus Ferula L. (Apiaceae Lindl.)T.S. Khosnutdinova0N.G. Gemejiyeva1Zh.Zh. Karzhaubekova2N.A. Sultanova3L.N. Gumilyov Eurasian National University, 2 Satpaev Str., Astana, KazakhstanInstitute of Botany and Phytointroduction, 36 “D” Timiryazev Str., Almaty, KazakhstanInstitute of Botany and Phytointroduction, 36 “D” Timiryazev Str., Almaty, KazakhstanL.N. Gumilyov Eurasian National University, 2 Satpaev Str., Astana, Kazakhstan The biologically active coumarins from Ferula L. species of the family Apiaceae Lindl. for the period 1970 to 2022 have been reviewed. The phytochemical investigation of different parts of Ferula L., including gum resin, leaves, fruits, seeds, roots, rhizomes, and resins led to the separation of different types of coumarins. Nearly 185 coumarins were isolated from 35 species of Ferula L. growing in different countries. Coumarins are represented mainly by umbelliferone (7-O-hydroxycoumarin) derivatives substituted in the C-7 position of aglycone, furanocoumarins and metabolites have terpene fragments, esters and glycosides. Umbelliferon is found as a taxon for the genus Ferula L. Some «unusual» metabolites have a furan fragment attached to the pyrone ring. Coumarins are of the psoralen type, containing a furan ring in the C-6 and C-7 positions of the primary skeleton. The rare coumarins with terpene fragments (hemiterpene, monoterpen, sesquiterpene) were reported. The biological activities of some extracts and individual metabolites such as antiinflammatory, cytotoxicity, antibacterial, antileishmanial, antiviral, antigenotoxic, antitumor, anticoagulant, antioxidant, antimycobacterial, inhibition a-glucosidase, antileishmanial were found. https://ect-journal.kz/index.php/ectj/article/view/1494Ferula L.CoumarinsFuranocoumarinsTerpene coumarinsEthersGlycosides |
| spellingShingle | T.S. Khosnutdinova N.G. Gemejiyeva Zh.Zh. Karzhaubekova N.A. Sultanova Coumarins of genus Ferula L. (Apiaceae Lindl.) Eurasian Chemico-Technological Journal Ferula L. Coumarins Furanocoumarins Terpene coumarins Ethers Glycosides |
| title | Coumarins of genus Ferula L. (Apiaceae Lindl.) |
| title_full | Coumarins of genus Ferula L. (Apiaceae Lindl.) |
| title_fullStr | Coumarins of genus Ferula L. (Apiaceae Lindl.) |
| title_full_unstemmed | Coumarins of genus Ferula L. (Apiaceae Lindl.) |
| title_short | Coumarins of genus Ferula L. (Apiaceae Lindl.) |
| title_sort | coumarins of genus ferula l apiaceae lindl |
| topic | Ferula L. Coumarins Furanocoumarins Terpene coumarins Ethers Glycosides |
| url | https://ect-journal.kz/index.php/ectj/article/view/1494 |
| work_keys_str_mv | AT tskhosnutdinova coumarinsofgenusferulalapiaceaelindl AT nggemejiyeva coumarinsofgenusferulalapiaceaelindl AT zhzhkarzhaubekova coumarinsofgenusferulalapiaceaelindl AT nasultanova coumarinsofgenusferulalapiaceaelindl |