Comparison of the efficacy of chemotherapy and allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia in first remission in adults
The aim of the study was to compare the efficacy of allogeneic hematopoietic stem cell transplantation (alloHSCT) and chemotherapy (CT) of acute myeloid leukemia (AML) in first remission (CR1), to identify factors influencing the results. We compare the efficacy alloHSCT in CR1 (n = 70) and CT (n =...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Academician I.P. Pavlov First St. Petersburg State Medical University
2015-09-01
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| Series: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
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| Online Access: | https://www.sci-notes.ru/jour/article/view/140 |
| _version_ | 1797697557450719232 |
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| author | S. N. Bondarenko I. S. Moiseev I. A. Samorodova T. L. Gindina M. A. Kucher O. A. Slesarchuk L. S. Zubarovskaya B. V. Afanasyev |
| author_facet | S. N. Bondarenko I. S. Moiseev I. A. Samorodova T. L. Gindina M. A. Kucher O. A. Slesarchuk L. S. Zubarovskaya B. V. Afanasyev |
| author_sort | S. N. Bondarenko |
| collection | DOAJ |
| description | The aim of the study was to compare the efficacy of allogeneic hematopoietic stem cell transplantation (alloHSCT) and chemotherapy (CT) of acute myeloid leukemia (AML) in first remission (CR1), to identify factors influencing the results. We compare the efficacy alloHSCT in CR1 (n = 70) and CT (n = 52). Patients were stratified by age, the level of leucocytes, the origin of AML, cytogenetic risk group and response to induction CT. Five-years overall and disease-free survival (OS and DFS) were higher in the group alloHSCT (67 and 65 % vs 46 and 30 % (p = 0.02 and p = 0.001)). Benefits of DFS after alloHSCT was in standard and high-risk cytogenetic groups (78 % versus 29 % (p = 0.001), and 34 % vs 17 % (p = 0.007)). The risk of relapse (RR) was 24 % in patients after alloHSCT vs. 57 % for CT (p = 0.003). Comparing the RR after alloHSCT and CT depending on the cytogenetic risk groups: standard (HR0.2(CI95 %0.07 - 0.56) p = 0.002), and high (HR0.27(CI95 %0.08-0.86) p = 0.03). Additional factors affect the RR were the origin of AML (de novo) (HR0.47 (CI95 %0.3-0.74) p = 0.001), the hyperleukocytosis (HR1.91 (CI95 %1.09 - 3.32) p = 0.02), and no remission after the first course CT (HR3.32(CI95 %1.57-7.0) p = 0.002). The efficacy of alloHSCT compared with CT is higher both in standard and high-risk cytogenetic group. |
| first_indexed | 2024-03-12T03:41:54Z |
| format | Article |
| id | doaj.art-aa02078d94b14f10a6b55ec63df57743 |
| institution | Directory Open Access Journal |
| issn | 1607-4181 |
| language | Russian |
| last_indexed | 2024-03-12T03:41:54Z |
| publishDate | 2015-09-01 |
| publisher | Academician I.P. Pavlov First St. Petersburg State Medical University |
| record_format | Article |
| series | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| spelling | doaj.art-aa02078d94b14f10a6b55ec63df577432023-09-03T13:02:40ZrusAcademician I.P. Pavlov First St. Petersburg State Medical UniversityУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова1607-41812015-09-01223668010.24884/1607-4181-2015-22-3-66-80136Comparison of the efficacy of chemotherapy and allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia in first remission in adultsS. N. Bondarenko0I. S. Moiseev1I. A. Samorodova2T. L. Gindina3M. A. Kucher4O. A. Slesarchuk5L. S. Zubarovskaya6B. V. Afanasyev7НИИ детской онкологии, гематологии и трансплантологии имени Р.М. Горбачевой; ФПО Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаНИИ детской онкологии, гематологии и трансплантологии имени Р.М. Горбачевой; ФПО Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаНИИ детской онкологии, гематологии и трансплантологии имени Р.М. Горбачевой; ФПО Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаНИИ детской онкологии, гематологии и трансплантологии имени Р.М. Горбачевой; ФПО Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаНИИ детской онкологии, гематологии и трансплантологии имени Р.М. Горбачевой; ФПО Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаНИИ детской онкологии, гематологии и трансплантологии имени Р.М. Горбачевой; ФПО Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаНИИ детской онкологии, гематологии и трансплантологии имени Р.М. Горбачевой; ФПО Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаНИИ детской онкологии, гематологии и трансплантологии имени Р.М. Горбачевой; ФПО Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаThe aim of the study was to compare the efficacy of allogeneic hematopoietic stem cell transplantation (alloHSCT) and chemotherapy (CT) of acute myeloid leukemia (AML) in first remission (CR1), to identify factors influencing the results. We compare the efficacy alloHSCT in CR1 (n = 70) and CT (n = 52). Patients were stratified by age, the level of leucocytes, the origin of AML, cytogenetic risk group and response to induction CT. Five-years overall and disease-free survival (OS and DFS) were higher in the group alloHSCT (67 and 65 % vs 46 and 30 % (p = 0.02 and p = 0.001)). Benefits of DFS after alloHSCT was in standard and high-risk cytogenetic groups (78 % versus 29 % (p = 0.001), and 34 % vs 17 % (p = 0.007)). The risk of relapse (RR) was 24 % in patients after alloHSCT vs. 57 % for CT (p = 0.003). Comparing the RR after alloHSCT and CT depending on the cytogenetic risk groups: standard (HR0.2(CI95 %0.07 - 0.56) p = 0.002), and high (HR0.27(CI95 %0.08-0.86) p = 0.03). Additional factors affect the RR were the origin of AML (de novo) (HR0.47 (CI95 %0.3-0.74) p = 0.001), the hyperleukocytosis (HR1.91 (CI95 %1.09 - 3.32) p = 0.02), and no remission after the first course CT (HR3.32(CI95 %1.57-7.0) p = 0.002). The efficacy of alloHSCT compared with CT is higher both in standard and high-risk cytogenetic group.https://www.sci-notes.ru/jour/article/view/140острый миелоидный лейкозхимиотерапиятрансплантация костного мозгаacute myeloid leukemiachemotherapyallogeneic hematopoietic stem cell transplantation |
| spellingShingle | S. N. Bondarenko I. S. Moiseev I. A. Samorodova T. L. Gindina M. A. Kucher O. A. Slesarchuk L. S. Zubarovskaya B. V. Afanasyev Comparison of the efficacy of chemotherapy and allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia in first remission in adults Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова острый миелоидный лейкоз химиотерапия трансплантация костного мозга acute myeloid leukemia chemotherapy allogeneic hematopoietic stem cell transplantation |
| title | Comparison of the efficacy of chemotherapy and allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia in first remission in adults |
| title_full | Comparison of the efficacy of chemotherapy and allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia in first remission in adults |
| title_fullStr | Comparison of the efficacy of chemotherapy and allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia in first remission in adults |
| title_full_unstemmed | Comparison of the efficacy of chemotherapy and allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia in first remission in adults |
| title_short | Comparison of the efficacy of chemotherapy and allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia in first remission in adults |
| title_sort | comparison of the efficacy of chemotherapy and allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia in first remission in adults |
| topic | острый миелоидный лейкоз химиотерапия трансплантация костного мозга acute myeloid leukemia chemotherapy allogeneic hematopoietic stem cell transplantation |
| url | https://www.sci-notes.ru/jour/article/view/140 |
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