Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons

Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons

Mutations in SPG11 cause a complicated autosomal recessive form of hereditary spastic paraplegia (HSP). Mechanistically, there are indications for the dysregulation of the GSK3β/βCat signaling pathway in SPG11. In this study, we tested the therapeutic potential of the GSK3β inhibitor, tideglusib, to...

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Bibliographic Details
Main Authors: Tatyana Pozner, Annika Schray, Martin Regensburger, Dieter Chichung Lie, Ursula Schlötzer-Schrehardt, Jürgen Winkler, Soeren Turan, Beate Winner
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Neuroscience
Subjects:
induced pluripotent stem cell
neuronal culture
SPG11
tideglusib
GSK3β inhibitor
hereditary spastic paraplegia
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00914/full

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