Asthma under control is inversely related with erosive esophagitis among healthy adults.
<h4>Background</h4>Some recent studies suggested that reflux esophagitis is positively correlated with asthma. However, there are debates on this issue. The aim of this study is to clarify the true association between reflux esophagitis and asthma in a large population.<h4>Methods&...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0210490 |
| _version_ | 1818443950962245632 |
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| author | Joo Hyun Lim Dong Ho Lee So Hee Lee Joo Sung Kim Hyun Chae Jung Sang-Heon Cho |
| author_facet | Joo Hyun Lim Dong Ho Lee So Hee Lee Joo Sung Kim Hyun Chae Jung Sang-Heon Cho |
| author_sort | Joo Hyun Lim |
| collection | DOAJ |
| description | <h4>Background</h4>Some recent studies suggested that reflux esophagitis is positively correlated with asthma. However, there are debates on this issue. The aim of this study is to clarify the true association between reflux esophagitis and asthma in a large population.<h4>Methods</h4>Medical records of subjects who received health surveillance checkup between January 2005 and December 2011 were reviewed. Their endoscopic findings, medical history, body mass index, and smoking history were analyzed. Erosive esophagitis was defined as endoscopically detected mucosal break at the Z-line, irrespective of reflux symptom. Information about asthma history was obtained from their questionnaires and medical records.<h4>Results</h4>Out of the total 15,999 patients, 986 had erosive esophagitis and 376 had asthma. In this population, erosive esophagitis was inversely related with asthma in univariable analysis (OR, 0.586; 95% CI, 0.342-1.003, p = 0.049). In multivariable analysis, asthma was demonstrated as an independent negative risk factor for erosive esophagitis (OR, 0.472; 95% CI, 0.257-0.869, p = 0.016), under adjustment with age (OR, 1.000; 95% CI, 0.994-1.006, p = 0.977), male sex (OR, 2.092; 95% CI, 1.683-2.601, p < 0.001), body mass index (OR, 1.115; 95% CI, 1.090-1.141, p < 0.001), smoking (OR, 1.584; 95% CI, 1.318-1.902, p < 0.001), and urban residence (OR, 1.363; 95% CI, 1.149-1.616, p < 0.001). Likewise, erosive esophagitis was shown to be an independent negative risk factor for asthma (OR, 0.558; 95% CI, 0.324-0.960, p = 0.035) under adjustment with age (OR, 1.025; 95% CI, 1.015-1.034, p <0.001), male sex (OR, 0.861; 95% CI, 0.691-1.074, p = 0.185), and body mass index (OR, 1.067; 95% CI, 1.030-1.106, p < 0.001) in multivariable analysis.<h4>Conclusions</h4>Contrary to previous studies, this large scale data showed inverse association between erosive esophagitis and asthma. Further studies investigating the clear mechanism of this phenomenon are warranted. |
| first_indexed | 2024-12-14T19:08:11Z |
| format | Article |
| id | doaj.art-aa051599e76c4eebb84cc6d99cc653a7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T19:08:11Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj.art-aa051599e76c4eebb84cc6d99cc653a72022-12-21T22:50:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01141e021049010.1371/journal.pone.0210490Asthma under control is inversely related with erosive esophagitis among healthy adults.Joo Hyun LimDong Ho LeeSo Hee LeeJoo Sung KimHyun Chae JungSang-Heon Cho<h4>Background</h4>Some recent studies suggested that reflux esophagitis is positively correlated with asthma. However, there are debates on this issue. The aim of this study is to clarify the true association between reflux esophagitis and asthma in a large population.<h4>Methods</h4>Medical records of subjects who received health surveillance checkup between January 2005 and December 2011 were reviewed. Their endoscopic findings, medical history, body mass index, and smoking history were analyzed. Erosive esophagitis was defined as endoscopically detected mucosal break at the Z-line, irrespective of reflux symptom. Information about asthma history was obtained from their questionnaires and medical records.<h4>Results</h4>Out of the total 15,999 patients, 986 had erosive esophagitis and 376 had asthma. In this population, erosive esophagitis was inversely related with asthma in univariable analysis (OR, 0.586; 95% CI, 0.342-1.003, p = 0.049). In multivariable analysis, asthma was demonstrated as an independent negative risk factor for erosive esophagitis (OR, 0.472; 95% CI, 0.257-0.869, p = 0.016), under adjustment with age (OR, 1.000; 95% CI, 0.994-1.006, p = 0.977), male sex (OR, 2.092; 95% CI, 1.683-2.601, p < 0.001), body mass index (OR, 1.115; 95% CI, 1.090-1.141, p < 0.001), smoking (OR, 1.584; 95% CI, 1.318-1.902, p < 0.001), and urban residence (OR, 1.363; 95% CI, 1.149-1.616, p < 0.001). Likewise, erosive esophagitis was shown to be an independent negative risk factor for asthma (OR, 0.558; 95% CI, 0.324-0.960, p = 0.035) under adjustment with age (OR, 1.025; 95% CI, 1.015-1.034, p <0.001), male sex (OR, 0.861; 95% CI, 0.691-1.074, p = 0.185), and body mass index (OR, 1.067; 95% CI, 1.030-1.106, p < 0.001) in multivariable analysis.<h4>Conclusions</h4>Contrary to previous studies, this large scale data showed inverse association between erosive esophagitis and asthma. Further studies investigating the clear mechanism of this phenomenon are warranted.https://doi.org/10.1371/journal.pone.0210490 |
| spellingShingle | Joo Hyun Lim Dong Ho Lee So Hee Lee Joo Sung Kim Hyun Chae Jung Sang-Heon Cho Asthma under control is inversely related with erosive esophagitis among healthy adults. PLoS ONE |
| title | Asthma under control is inversely related with erosive esophagitis among healthy adults. |
| title_full | Asthma under control is inversely related with erosive esophagitis among healthy adults. |
| title_fullStr | Asthma under control is inversely related with erosive esophagitis among healthy adults. |
| title_full_unstemmed | Asthma under control is inversely related with erosive esophagitis among healthy adults. |
| title_short | Asthma under control is inversely related with erosive esophagitis among healthy adults. |
| title_sort | asthma under control is inversely related with erosive esophagitis among healthy adults |
| url | https://doi.org/10.1371/journal.pone.0210490 |
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