The role of sFlt1/PlGF ratio in the assessment of preeclampsia and pregnancy-related hypertensive disorders
Preeclampsia is a major cause of maternal and fetal morbidity and mortality. Early recognition of the disease may be challenging. Complications may precede the onset of clinical symptoms and medical intervention is often delayed. Moreover, in the absence of specific clinical signs, many patients w...
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2021-07-01
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| Series: | Swiss Medical Weekly |
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| Online Access: | https://www.smw.ch/index.php/smw/article/view/3030 |
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| author | Jonathan Baert Catherine McCarey Nadia Berkane Begoña Martinez-de-Tejada Yvan Vial Wawrzyniec Rieder |
| author_facet | Jonathan Baert Catherine McCarey Nadia Berkane Begoña Martinez-de-Tejada Yvan Vial Wawrzyniec Rieder |
| author_sort | Jonathan Baert |
| collection | DOAJ |
| description |
Preeclampsia is a major cause of maternal and fetal morbidity and mortality. Early recognition of the disease may be challenging. Complications may precede the onset of clinical symptoms and medical intervention is often delayed. Moreover, in the absence of specific clinical signs, many patients will present symptoms mimicking the disease without ever being diagnosed with preeclampsia. This situation may, however, lead to medical interventions and cause unnecessary stress for the patient. For many years, research tried to evaluate the significance of serum biomarkers as early indicators of preeclampsia. Among many, the sFlt-1/PlGF ratio, given its performance, aroused the greatest interest. This article reviews current knowledge on the subject, focusing on a Swiss perspective.
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| first_indexed | 2024-04-11T04:27:21Z |
| format | Article |
| id | doaj.art-aa05a0105cd14366ae62762ef8f1d8ad |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2025-02-18T09:50:09Z |
| publishDate | 2021-07-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-aa05a0105cd14366ae62762ef8f1d8ad2024-11-02T11:59:24ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972021-07-01151272810.4414/smw.2021.20533The role of sFlt1/PlGF ratio in the assessment of preeclampsia and pregnancy-related hypertensive disordersJonathan Baert0Catherine McCarey1Nadia Berkane2Begoña Martinez-de-Tejada3Yvan Vial4Wawrzyniec Rieder5Obstetric Unit, Woman-Mother-Child Department, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland; Faculty of Medicine, University of Lausanne, SwitzerlandObstetric Division, Department of Paediatrics, Gynaecology and Obstetrics, University Hospitals of Geneva (HUG), Geneva, Switzerland; Faculty of Medicine, University of Geneva, SwitzerlandObstetric Division, Department of Paediatrics, Gynaecology and Obstetrics, University Hospitals of Geneva (HUG), Geneva, SwitzerlandObstetric Division, Department of Paediatrics, Gynaecology and Obstetrics, University Hospitals of Geneva (HUG), Geneva, Switzerland; Faculty of Medicine, University of Geneva, SwitzerlandObstetric Unit, Woman-Mother-Child Department, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland; Faculty of Medicine, University of Lausanne, SwitzerlandObstetric Unit, Woman-Mother-Child Department, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland; Faculty of Medicine, University of Lausanne, Switzerland Preeclampsia is a major cause of maternal and fetal morbidity and mortality. Early recognition of the disease may be challenging. Complications may precede the onset of clinical symptoms and medical intervention is often delayed. Moreover, in the absence of specific clinical signs, many patients will present symptoms mimicking the disease without ever being diagnosed with preeclampsia. This situation may, however, lead to medical interventions and cause unnecessary stress for the patient. For many years, research tried to evaluate the significance of serum biomarkers as early indicators of preeclampsia. Among many, the sFlt-1/PlGF ratio, given its performance, aroused the greatest interest. This article reviews current knowledge on the subject, focusing on a Swiss perspective. https://www.smw.ch/index.php/smw/article/view/3030preeclampsiaserum biomarkerssFlt-1/PlGF ratioPregnancy related hypertensive disorders |
| spellingShingle | Jonathan Baert Catherine McCarey Nadia Berkane Begoña Martinez-de-Tejada Yvan Vial Wawrzyniec Rieder The role of sFlt1/PlGF ratio in the assessment of preeclampsia and pregnancy-related hypertensive disorders Swiss Medical Weekly preeclampsia serum biomarkers sFlt-1/PlGF ratio Pregnancy related hypertensive disorders |
| title | The role of sFlt1/PlGF ratio in the assessment of preeclampsia and pregnancy-related hypertensive disorders |
| title_full | The role of sFlt1/PlGF ratio in the assessment of preeclampsia and pregnancy-related hypertensive disorders |
| title_fullStr | The role of sFlt1/PlGF ratio in the assessment of preeclampsia and pregnancy-related hypertensive disorders |
| title_full_unstemmed | The role of sFlt1/PlGF ratio in the assessment of preeclampsia and pregnancy-related hypertensive disorders |
| title_short | The role of sFlt1/PlGF ratio in the assessment of preeclampsia and pregnancy-related hypertensive disorders |
| title_sort | role of sflt1 plgf ratio in the assessment of preeclampsia and pregnancy related hypertensive disorders |
| topic | preeclampsia serum biomarkers sFlt-1/PlGF ratio Pregnancy related hypertensive disorders |
| url | https://www.smw.ch/index.php/smw/article/view/3030 |
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