SHIP-1 Regulates Phagocytosis and M2 Polarization Through the PI3K/Akt–STAT5–Trib1 Circuit in Pseudomonas aeruginosa Infection

SHIP-1 Regulates Phagocytosis and M2 Polarization Through the PI3K/Akt–STAT5–Trib1 Circuit in Pseudomonas aeruginosa Infection

SHIP-1 is an inositol phosphatase that hydrolyzes phosphatidylinositol 3-kinase (PI3K) products and negatively regulates protein kinase B (Akt) activity, thereby modulating a variety of cellular processes in mammals. However, the role of SHIP-1 in bacterial-induced sepsis is largely unknown. Here, w...

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Bibliographic Details
Main Authors: Shugang Qin, Jiaxin Li, Chuanmin Zhou, Breanna Privratsky, Jacob Schettler, Xin Deng, Zhenwei Xia, Yong Zeng, Hong Wu, Min Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
Pseudomonas aeruginosa
SHIP-1
PI3K
Akt
STAT5
M1 macrophages
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00307/full

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