SHIP-1 Regulates Phagocytosis and M2 Polarization Through the PI3K/Akt–STAT5–Trib1 Circuit in Pseudomonas aeruginosa Infection

SHIP-1 Regulates Phagocytosis and M2 Polarization Through the PI3K/Akt–STAT5–Trib1 Circuit in Pseudomonas aeruginosa Infection

SHIP-1 is an inositol phosphatase that hydrolyzes phosphatidylinositol 3-kinase (PI3K) products and negatively regulates protein kinase B (Akt) activity, thereby modulating a variety of cellular processes in mammals. However, the role of SHIP-1 in bacterial-induced sepsis is largely unknown. Here, w...

Bibliográfalaš dieđut
Váldodahkkit:	Shugang Qin, Jiaxin Li, Chuanmin Zhou, Breanna Privratsky, Jacob Schettler, Xin Deng, Zhenwei Xia, Yong Zeng, Hong Wu, Min Wu
Materiálatiipa:	Artihkal
Giella:	English
Almmustuhtton:	Frontiers Media S.A. 2020-03-01
Ráidu:	Frontiers in Immunology
Fáttát:	Pseudomonas aeruginosa SHIP-1 PI3K Akt STAT5 M1 macrophages
Liŋkkat:	https://www.frontiersin.org/article/10.3389/fimmu.2020.00307/full

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