Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus

Uncaria rhynchophylla is a medicinal herb used for convulsive disorders in Oriental medicine. In this study, the effect of the methanol extract of Uncaria rhynchophylla against N-methyl-D-aspartate (NMDA)-induced excitotoxicity was investigated. Pretreatment with the extract of Uncaria rhynchopylla...

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Main Authors: Jongseok Lee, Dongwook Son, Pyeongjae Lee, Dae-Keun Kim, Min-Chul Shin, Mi-Hyeon Jang, Chang-Ju Kim, Yong-Sik Kim, Sun-Yeou Kim, Hocheol Kim
Format: Article
Language:English
Published: Elsevier 2003-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319326970
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author Jongseok Lee
Dongwook Son
Pyeongjae Lee
Dae-Keun Kim
Min-Chul Shin
Mi-Hyeon Jang
Chang-Ju Kim
Yong-Sik Kim
Sun-Yeou Kim
Hocheol Kim
author_facet Jongseok Lee
Dongwook Son
Pyeongjae Lee
Dae-Keun Kim
Min-Chul Shin
Mi-Hyeon Jang
Chang-Ju Kim
Yong-Sik Kim
Sun-Yeou Kim
Hocheol Kim
author_sort Jongseok Lee
collection DOAJ
description Uncaria rhynchophylla is a medicinal herb used for convulsive disorders in Oriental medicine. In this study, the effect of the methanol extract of Uncaria rhynchophylla against N-methyl-D-aspartate (NMDA)-induced excitotoxicity was investigated. Pretreatment with the extract of Uncaria rhynchopylla reduced the degree of neuronal damage induced by NMDA exposure in cultured hippocampal slices. In the patch clamp study, Uncaria rhynchophylla significantly inhibited NMDA receptor-activated ion current in acutely dissociated hippocampal CA1 neurons. These results indicate that Uncaria rhynchophylla offers protection against NMDA-induced neuronal injury and inhibitory action on NMDA receptor-mediated ion current may be a mechanism behind the neuroprotective effect of Uncaria rhynchophylla.
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spelling doaj.art-aa06c2ae5eaf42668462733db99389d62022-12-21T18:32:10ZengElsevierJournal of Pharmacological Sciences1347-86132003-01-019217073Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat HippocampusJongseok Lee0Dongwook Son1Pyeongjae Lee2Dae-Keun Kim3Min-Chul Shin4Mi-Hyeon Jang5Chang-Ju Kim6Yong-Sik Kim7Sun-Yeou Kim8Hocheol Kim9Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-ku, Seoul 130-701, KoreaDepartment of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-ku, Seoul 130-701, KoreaDepartment of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-ku, Seoul 130-701, KoreaDepartment of Herbal Pharmacology, College of Pharmacy, Woosuk University, Chonju, KoreaDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul, KoreaDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul, KoreaDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul, KoreaDepartment of Pharmacology, Seoul National University College of Medicine and Neuroscience Research Institute of Medical Research Center, Seoul, KoreaDepartment of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-ku, Seoul 130-701, KoreaDepartment of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-ku, Seoul 130-701, KoreaUncaria rhynchophylla is a medicinal herb used for convulsive disorders in Oriental medicine. In this study, the effect of the methanol extract of Uncaria rhynchophylla against N-methyl-D-aspartate (NMDA)-induced excitotoxicity was investigated. Pretreatment with the extract of Uncaria rhynchopylla reduced the degree of neuronal damage induced by NMDA exposure in cultured hippocampal slices. In the patch clamp study, Uncaria rhynchophylla significantly inhibited NMDA receptor-activated ion current in acutely dissociated hippocampal CA1 neurons. These results indicate that Uncaria rhynchophylla offers protection against NMDA-induced neuronal injury and inhibitory action on NMDA receptor-mediated ion current may be a mechanism behind the neuroprotective effect of Uncaria rhynchophylla.http://www.sciencedirect.com/science/article/pii/S1347861319326970
spellingShingle Jongseok Lee
Dongwook Son
Pyeongjae Lee
Dae-Keun Kim
Min-Chul Shin
Mi-Hyeon Jang
Chang-Ju Kim
Yong-Sik Kim
Sun-Yeou Kim
Hocheol Kim
Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus
Journal of Pharmacological Sciences
title Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus
title_full Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus
title_fullStr Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus
title_full_unstemmed Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus
title_short Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus
title_sort protective effect of methanol extract of uncaria rhynchophylla against excitotoxicity induced by n methyl d aspartate in rat hippocampus
url http://www.sciencedirect.com/science/article/pii/S1347861319326970
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