Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus
Uncaria rhynchophylla is a medicinal herb used for convulsive disorders in Oriental medicine. In this study, the effect of the methanol extract of Uncaria rhynchophylla against N-methyl-D-aspartate (NMDA)-induced excitotoxicity was investigated. Pretreatment with the extract of Uncaria rhynchopylla...
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Elsevier
2003-01-01
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Series: | Journal of Pharmacological Sciences |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319326970 |
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author | Jongseok Lee Dongwook Son Pyeongjae Lee Dae-Keun Kim Min-Chul Shin Mi-Hyeon Jang Chang-Ju Kim Yong-Sik Kim Sun-Yeou Kim Hocheol Kim |
author_facet | Jongseok Lee Dongwook Son Pyeongjae Lee Dae-Keun Kim Min-Chul Shin Mi-Hyeon Jang Chang-Ju Kim Yong-Sik Kim Sun-Yeou Kim Hocheol Kim |
author_sort | Jongseok Lee |
collection | DOAJ |
description | Uncaria rhynchophylla is a medicinal herb used for convulsive disorders in Oriental medicine. In this study, the effect of the methanol extract of Uncaria rhynchophylla against N-methyl-D-aspartate (NMDA)-induced excitotoxicity was investigated. Pretreatment with the extract of Uncaria rhynchopylla reduced the degree of neuronal damage induced by NMDA exposure in cultured hippocampal slices. In the patch clamp study, Uncaria rhynchophylla significantly inhibited NMDA receptor-activated ion current in acutely dissociated hippocampal CA1 neurons. These results indicate that Uncaria rhynchophylla offers protection against NMDA-induced neuronal injury and inhibitory action on NMDA receptor-mediated ion current may be a mechanism behind the neuroprotective effect of Uncaria rhynchophylla. |
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institution | Directory Open Access Journal |
issn | 1347-8613 |
language | English |
last_indexed | 2024-12-22T08:43:27Z |
publishDate | 2003-01-01 |
publisher | Elsevier |
record_format | Article |
series | Journal of Pharmacological Sciences |
spelling | doaj.art-aa06c2ae5eaf42668462733db99389d62022-12-21T18:32:10ZengElsevierJournal of Pharmacological Sciences1347-86132003-01-019217073Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat HippocampusJongseok Lee0Dongwook Son1Pyeongjae Lee2Dae-Keun Kim3Min-Chul Shin4Mi-Hyeon Jang5Chang-Ju Kim6Yong-Sik Kim7Sun-Yeou Kim8Hocheol Kim9Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-ku, Seoul 130-701, KoreaDepartment of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-ku, Seoul 130-701, KoreaDepartment of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-ku, Seoul 130-701, KoreaDepartment of Herbal Pharmacology, College of Pharmacy, Woosuk University, Chonju, KoreaDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul, KoreaDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul, KoreaDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul, KoreaDepartment of Pharmacology, Seoul National University College of Medicine and Neuroscience Research Institute of Medical Research Center, Seoul, KoreaDepartment of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-ku, Seoul 130-701, KoreaDepartment of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-ku, Seoul 130-701, KoreaUncaria rhynchophylla is a medicinal herb used for convulsive disorders in Oriental medicine. In this study, the effect of the methanol extract of Uncaria rhynchophylla against N-methyl-D-aspartate (NMDA)-induced excitotoxicity was investigated. Pretreatment with the extract of Uncaria rhynchopylla reduced the degree of neuronal damage induced by NMDA exposure in cultured hippocampal slices. In the patch clamp study, Uncaria rhynchophylla significantly inhibited NMDA receptor-activated ion current in acutely dissociated hippocampal CA1 neurons. These results indicate that Uncaria rhynchophylla offers protection against NMDA-induced neuronal injury and inhibitory action on NMDA receptor-mediated ion current may be a mechanism behind the neuroprotective effect of Uncaria rhynchophylla.http://www.sciencedirect.com/science/article/pii/S1347861319326970 |
spellingShingle | Jongseok Lee Dongwook Son Pyeongjae Lee Dae-Keun Kim Min-Chul Shin Mi-Hyeon Jang Chang-Ju Kim Yong-Sik Kim Sun-Yeou Kim Hocheol Kim Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus Journal of Pharmacological Sciences |
title | Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus |
title_full | Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus |
title_fullStr | Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus |
title_full_unstemmed | Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus |
title_short | Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus |
title_sort | protective effect of methanol extract of uncaria rhynchophylla against excitotoxicity induced by n methyl d aspartate in rat hippocampus |
url | http://www.sciencedirect.com/science/article/pii/S1347861319326970 |
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