Cervical HPV infection in Guangzhou, China: an epidemiological study of 198,111 women from 2015 to 2021
Persistent high-risk human papillomavirus (HPV) infection is the pivotal cause of cervical carcinogenesis. HPV types distribution varies greatly by region, and its long-term changes of prevalence remain to be fully characterized in China. Here, the largest population of 198,111 consecutive women who...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2176009 |
| _version_ | 1826898956054953984 |
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| author | Xiaohan Yang Yuanyuan Li Yuan Tang Zhiyu Li Sanfeng Wang Xiping Luo Tianwen He Aihua Yin Mingyong Luo |
| author_facet | Xiaohan Yang Yuanyuan Li Yuan Tang Zhiyu Li Sanfeng Wang Xiping Luo Tianwen He Aihua Yin Mingyong Luo |
| author_sort | Xiaohan Yang |
| collection | DOAJ |
| description | Persistent high-risk human papillomavirus (HPV) infection is the pivotal cause of cervical carcinogenesis. HPV types distribution varies greatly by region, and its long-term changes of prevalence remain to be fully characterized in China. Here, the largest population of 198,111 consecutive women who underwent routine cervical screening were investigated from 2015 to 2021 in Guangzhou, south China. The results showed that the overall HPV prevalence was 21.66% (42,911/198,111), and the annual prevalence increased significantly from 2015 to 2021 (p < 0.001). HPV52, 16, 58, CP8304, 51, 53, 39, and 68 were the most prevalent HPV types. The relative HPV-positive rate correlated positively with the progression of cervical intraepithelial neoplasia (p < 0.001); HPV16 was the predominant carcinogenic type, followed by HPV52 and HPV18. HPV infections were significantly age-specific, and 26.51% (11,375/42,911) of cases were caused by multiple HPV types. In addition, HPV infections typically cleared over a median time of 16 (interquartile range 9–31) months, and the clearance of HPV16 was significantly faster than that of other types (p < 0.001). These findings may serve as a guide for local governments to evaluate HPV vaccination and cervical cancer prevention strategies in south China. |
| first_indexed | 2024-03-11T16:35:26Z |
| format | Article |
| id | doaj.art-aa084a603b58435e958c5f5f819b5bac |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2025-02-17T06:44:30Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-aa084a603b58435e958c5f5f819b5bac2025-01-06T13:38:29ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112110.1080/22221751.2023.2176009Cervical HPV infection in Guangzhou, China: an epidemiological study of 198,111 women from 2015 to 2021Xiaohan Yang0Yuanyuan Li1Yuan Tang2Zhiyu Li3Sanfeng Wang4Xiping Luo5Tianwen He6Aihua Yin7Mingyong Luo8Medical Genetic Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of ChinaGuangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangdong Women and Children's Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangdong Women and Children's Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaDepartment of Gynecology and Obstetrics, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of ChinaDepartment of Gynecology and Obstetrics, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of ChinaMedical Genetic Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of ChinaMedical Genetic Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of ChinaMedical Genetic Center, Guangdong Women and Children Hospital, Guangzhou, People’s Republic of ChinaPersistent high-risk human papillomavirus (HPV) infection is the pivotal cause of cervical carcinogenesis. HPV types distribution varies greatly by region, and its long-term changes of prevalence remain to be fully characterized in China. Here, the largest population of 198,111 consecutive women who underwent routine cervical screening were investigated from 2015 to 2021 in Guangzhou, south China. The results showed that the overall HPV prevalence was 21.66% (42,911/198,111), and the annual prevalence increased significantly from 2015 to 2021 (p < 0.001). HPV52, 16, 58, CP8304, 51, 53, 39, and 68 were the most prevalent HPV types. The relative HPV-positive rate correlated positively with the progression of cervical intraepithelial neoplasia (p < 0.001); HPV16 was the predominant carcinogenic type, followed by HPV52 and HPV18. HPV infections were significantly age-specific, and 26.51% (11,375/42,911) of cases were caused by multiple HPV types. In addition, HPV infections typically cleared over a median time of 16 (interquartile range 9–31) months, and the clearance of HPV16 was significantly faster than that of other types (p < 0.001). These findings may serve as a guide for local governments to evaluate HPV vaccination and cervical cancer prevention strategies in south China.https://www.tandfonline.com/doi/10.1080/22221751.2023.2176009Human papillomavirusepidemiologynormal cervixcervical lesions |
| spellingShingle | Xiaohan Yang Yuanyuan Li Yuan Tang Zhiyu Li Sanfeng Wang Xiping Luo Tianwen He Aihua Yin Mingyong Luo Cervical HPV infection in Guangzhou, China: an epidemiological study of 198,111 women from 2015 to 2021 Emerging Microbes and Infections Human papillomavirus epidemiology normal cervix cervical lesions |
| title | Cervical HPV infection in Guangzhou, China: an epidemiological study of 198,111 women from 2015 to 2021 |
| title_full | Cervical HPV infection in Guangzhou, China: an epidemiological study of 198,111 women from 2015 to 2021 |
| title_fullStr | Cervical HPV infection in Guangzhou, China: an epidemiological study of 198,111 women from 2015 to 2021 |
| title_full_unstemmed | Cervical HPV infection in Guangzhou, China: an epidemiological study of 198,111 women from 2015 to 2021 |
| title_short | Cervical HPV infection in Guangzhou, China: an epidemiological study of 198,111 women from 2015 to 2021 |
| title_sort | cervical hpv infection in guangzhou china an epidemiological study of 198 111 women from 2015 to 2021 |
| topic | Human papillomavirus epidemiology normal cervix cervical lesions |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2176009 |
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