Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis
Multiple sclerosis (MS), a neuroinflammation that results in neurodegeneration, is the most prevalent central nervous system inflammatory disease in young people. A diet rich in antioxidants is known to decrease the production/activity of pro-inflammatory cytokines and have a positive impact on the...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2023-09-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100662&tlng=en |
| _version_ | 1797688319522373632 |
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| author | S. Mungan I. Guzel B.C. Demirdogen |
| author_facet | S. Mungan I. Guzel B.C. Demirdogen |
| author_sort | S. Mungan |
| collection | DOAJ |
| description | Multiple sclerosis (MS), a neuroinflammation that results in neurodegeneration, is the most prevalent central nervous system inflammatory disease in young people. A diet rich in antioxidants is known to decrease the production/activity of pro-inflammatory cytokines and have a positive impact on the prognosis of MS. The purpose of this study was to assess if dietary antioxidant capacity is related to Expanded Disability Status Scale (EDSS) scores in patients with MS. Patients with MS (n=220; 137 women and 83 men) were asked to complete a questionnaire on diet. According to the EDSS score, patients were split into two groups (group 1: EDSS ≤5 and group 2: EDSS >5). Analyzed risk variables were antioxidant levels and demographic data. A nutritional database tool (BeBiS 4 software, Germany) created for the evaluation of Turkish foods was used to examine the questionnaire findings. Age, vitamin A, retinol, vitamin D, vitamin E, and vitamin C were significantly different between groups (P<0.05). The levels of vitamins A, D, E, C, and retinol were significantly correlated, according to Pearson's correlation analysis. Receiver operator characteristic curve analysis revealed that vitamin A, vitamin D, and vitamin C levels were discriminating variables in group 2 patients (EDSS >5). The current study has shown that antioxidant levels obtained by EDSS may be useful in determining illness severity and treatment success of patients with MS. Further clinical trials have been initiated in MS patients with more effective antioxidants. |
| first_indexed | 2024-03-12T01:29:32Z |
| format | Article |
| id | doaj.art-aa0a4f5779024f87b2f125eaa2fbee75 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-03-12T01:29:32Z |
| publishDate | 2023-09-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-aa0a4f5779024f87b2f125eaa2fbee752023-09-12T07:41:54ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2023-09-015610.1590/1414-431x2023e12776Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosisS. Munganhttps://orcid.org/0000-0002-6469-5185I. Guzelhttps://orcid.org/0000-0002-1891-6178B.C. Demirdogenhttps://orcid.org/0000-0002-1536-6123Multiple sclerosis (MS), a neuroinflammation that results in neurodegeneration, is the most prevalent central nervous system inflammatory disease in young people. A diet rich in antioxidants is known to decrease the production/activity of pro-inflammatory cytokines and have a positive impact on the prognosis of MS. The purpose of this study was to assess if dietary antioxidant capacity is related to Expanded Disability Status Scale (EDSS) scores in patients with MS. Patients with MS (n=220; 137 women and 83 men) were asked to complete a questionnaire on diet. According to the EDSS score, patients were split into two groups (group 1: EDSS ≤5 and group 2: EDSS >5). Analyzed risk variables were antioxidant levels and demographic data. A nutritional database tool (BeBiS 4 software, Germany) created for the evaluation of Turkish foods was used to examine the questionnaire findings. Age, vitamin A, retinol, vitamin D, vitamin E, and vitamin C were significantly different between groups (P<0.05). The levels of vitamins A, D, E, C, and retinol were significantly correlated, according to Pearson's correlation analysis. Receiver operator characteristic curve analysis revealed that vitamin A, vitamin D, and vitamin C levels were discriminating variables in group 2 patients (EDSS >5). The current study has shown that antioxidant levels obtained by EDSS may be useful in determining illness severity and treatment success of patients with MS. Further clinical trials have been initiated in MS patients with more effective antioxidants.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100662&tlng=enMultiple sclerosisExpanded Disability Status ScaleAntioxidant capacity |
| spellingShingle | S. Mungan I. Guzel B.C. Demirdogen Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis Brazilian Journal of Medical and Biological Research Multiple sclerosis Expanded Disability Status Scale Antioxidant capacity |
| title | Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis |
| title_full | Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis |
| title_fullStr | Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis |
| title_full_unstemmed | Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis |
| title_short | Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis |
| title_sort | association between expanded disability status scale score and dietary antioxidant capacity in patients with multiple sclerosis |
| topic | Multiple sclerosis Expanded Disability Status Scale Antioxidant capacity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100662&tlng=en |
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