CML/RAGE Signal Bridges a Common Pathogenesis Between Atherosclerosis and Non-alcoholic Fatty Liver
Non-alcoholic fatty liver disease (NAFLD) has become a common chronic disease in the world. NAFLD is not only a simple intrahepatic lesion, but also affects the occurrence of a variety of extrahepatic complications. In particular, cardiovascular complications are particularly serious, which is the m...
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2020.583943/full |
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| author | Qiwen Pang Zhen Sun Chen Shao Honghua Cai Zhengyang Bao Lin Wang Lihua Li Lele Jing Lili Zhang Zhongqun Wang |
| author_facet | Qiwen Pang Zhen Sun Chen Shao Honghua Cai Zhengyang Bao Lin Wang Lihua Li Lele Jing Lili Zhang Zhongqun Wang |
| author_sort | Qiwen Pang |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) has become a common chronic disease in the world. NAFLD is not only a simple intrahepatic lesion, but also affects the occurrence of a variety of extrahepatic complications. In particular, cardiovascular complications are particularly serious, which is the main cause of death in patients with NAFLD. To study the relationship between NAFLD and AS may be a new way to improve the quality of life in patients with NAFLD. As we all known, inflammatory response plays an important role in the occurrence and development of NAFLD and AS. In this study, we found that the accumulation of Nε-carboxymethyllysine (CML) in the liver leads to hepatic steatosis. CML can induce the expression of interleukin (IL-1β), interleukin (IL-6), tumor necrosis factor (TNF-α), C-reactionprotein (CRP) by binding with advanced glycosylation end-product receptor (RAGE) and accelerate the development of AS. After silencing RAGE expression, the expression of pro-inflammatory cytokines was inhibited and liver and aorta pathological changes were relieved. In conclusion, CML/RAGE signal promotes the progression of non-alcoholic fatty liver disease and atherosclerosis. We hope to provide new ideas for the study of liver vascular dialogue in multi organ communication. |
| first_indexed | 2024-12-12T16:33:35Z |
| format | Article |
| id | doaj.art-aa0b12f2045c4d16875f1ed545d70447 |
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| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-12T16:33:35Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-aa0b12f2045c4d16875f1ed545d704472022-12-22T00:18:44ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-11-01710.3389/fmed.2020.583943583943CML/RAGE Signal Bridges a Common Pathogenesis Between Atherosclerosis and Non-alcoholic Fatty LiverQiwen Pang0Zhen Sun1Chen Shao2Honghua Cai3Zhengyang Bao4Lin Wang5Lihua Li6Lele Jing7Lili Zhang8Zhongqun WangDepartment of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Burn Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Internal Medicine, Affiliated Hospital of Wuxi Maternity and Child Health of Nanjing Medical University, Wuxi, ChinaDepartment of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Pathology, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaNon-alcoholic fatty liver disease (NAFLD) has become a common chronic disease in the world. NAFLD is not only a simple intrahepatic lesion, but also affects the occurrence of a variety of extrahepatic complications. In particular, cardiovascular complications are particularly serious, which is the main cause of death in patients with NAFLD. To study the relationship between NAFLD and AS may be a new way to improve the quality of life in patients with NAFLD. As we all known, inflammatory response plays an important role in the occurrence and development of NAFLD and AS. In this study, we found that the accumulation of Nε-carboxymethyllysine (CML) in the liver leads to hepatic steatosis. CML can induce the expression of interleukin (IL-1β), interleukin (IL-6), tumor necrosis factor (TNF-α), C-reactionprotein (CRP) by binding with advanced glycosylation end-product receptor (RAGE) and accelerate the development of AS. After silencing RAGE expression, the expression of pro-inflammatory cytokines was inhibited and liver and aorta pathological changes were relieved. In conclusion, CML/RAGE signal promotes the progression of non-alcoholic fatty liver disease and atherosclerosis. We hope to provide new ideas for the study of liver vascular dialogue in multi organ communication.https://www.frontiersin.org/articles/10.3389/fmed.2020.583943/fullatherosclerosis (AS)non-alcoholic fatty liver disease (NAFLD)Nε-carboxymethyllysine (CML)advanced glycosylation end-product receptor (RAGE)pro-inflammatory |
| spellingShingle | Qiwen Pang Zhen Sun Chen Shao Honghua Cai Zhengyang Bao Lin Wang Lihua Li Lele Jing Lili Zhang Zhongqun Wang CML/RAGE Signal Bridges a Common Pathogenesis Between Atherosclerosis and Non-alcoholic Fatty Liver Frontiers in Medicine atherosclerosis (AS) non-alcoholic fatty liver disease (NAFLD) Nε-carboxymethyllysine (CML) advanced glycosylation end-product receptor (RAGE) pro-inflammatory |
| title | CML/RAGE Signal Bridges a Common Pathogenesis Between Atherosclerosis and Non-alcoholic Fatty Liver |
| title_full | CML/RAGE Signal Bridges a Common Pathogenesis Between Atherosclerosis and Non-alcoholic Fatty Liver |
| title_fullStr | CML/RAGE Signal Bridges a Common Pathogenesis Between Atherosclerosis and Non-alcoholic Fatty Liver |
| title_full_unstemmed | CML/RAGE Signal Bridges a Common Pathogenesis Between Atherosclerosis and Non-alcoholic Fatty Liver |
| title_short | CML/RAGE Signal Bridges a Common Pathogenesis Between Atherosclerosis and Non-alcoholic Fatty Liver |
| title_sort | cml rage signal bridges a common pathogenesis between atherosclerosis and non alcoholic fatty liver |
| topic | atherosclerosis (AS) non-alcoholic fatty liver disease (NAFLD) Nε-carboxymethyllysine (CML) advanced glycosylation end-product receptor (RAGE) pro-inflammatory |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2020.583943/full |
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