APOLIPOPROTEIN E AND THE PROGRESSION OF RENAL NEPHROPATHY IN PACIENTS WITH DIABETES
Apolipoprotein (Apo) E plasma is a key factor of lipid metabolism. It is a surface component of triglycerides-rich lipoproteins, low-density lipoproteins (VLDL), chylomicron remnants and high-density lipoproteins (HDL). Most of the circulating ApoE is of hepatic origin, but can also be synthesized...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2019-09-01
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| Series: | Romanian Medical Journal |
| Subjects: | |
| Online Access: | https://revistemedicale.amaltea.ro/Romanian_MEDICAL_Journal/Revista_MEDICALA_ROMANA-2019-Nr.3/RMJ_2019_3_Art-09.pdf |
| _version_ | 1797333763656515584 |
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| author | Silviu Daniel Moldovan Romana Olivia Popeţiu Oana Lucia Amza Maria Puşchiţă |
| author_facet | Silviu Daniel Moldovan Romana Olivia Popeţiu Oana Lucia Amza Maria Puşchiţă |
| author_sort | Silviu Daniel Moldovan |
| collection | DOAJ |
| description | Apolipoprotein (Apo) E plasma is a key factor of lipid metabolism. It is a surface component of triglycerides-rich lipoproteins, low-density lipoproteins (VLDL), chylomicron remnants and high-density lipoproteins
(HDL). Most of the circulating ApoE is of hepatic origin, but can also be synthesized in the spleen, kidneys,
lungs, muscle and central nervous system (6). The biological activity of ApoE depends on the polymorphism
of the gene. ApoE is located on the long arm of chromosome 19, described as 3 alleles (ε2, ε3 and Ε4), which codifies 3 isoforms of ApoE: ε2, Ε3 and ε4 respectively. The clear, detailed definition of ApoE function in the 3 target locations – the hypothalamus, adipose tissue and plasma – can lead to an effective screening method based on the determination of the plasma lipid profile, ApoE becoming a readily detectable marker of metabolic disorder (11,12). |
| first_indexed | 2024-03-08T08:09:47Z |
| format | Article |
| id | doaj.art-aa0b453a009643a7b286fe98e67babec |
| institution | Directory Open Access Journal |
| issn | 1220-5478 2069-606X |
| language | English |
| last_indexed | 2024-03-08T08:09:47Z |
| publishDate | 2019-09-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Medical Journal |
| spelling | doaj.art-aa0b453a009643a7b286fe98e67babec2024-02-02T09:32:41ZengAmaltea Medical Publishing HouseRomanian Medical Journal1220-54782069-606X2019-09-0166322923210.37897/RMJ.2019.3.9APOLIPOPROTEIN E AND THE PROGRESSION OF RENAL NEPHROPATHY IN PACIENTS WITH DIABETESSilviu Daniel Moldovan0Romana Olivia Popeţiu1Oana Lucia Amza2Maria Puşchiţă3Facultatea de Medicină Universitatea de Vest „Vasile Goldiş“, Arad, România; Spitalul Clinic Judeţean de Urgenţă, Arad, RomâniaFacultatea de Medicină Universitatea de Vest „Vasile Goldiş“, Arad, România; Spitalul Clinic Judeţean de Urgenţă, Arad, RomâniaFacultatea de Medicină Universitatea de Vest „Vasile Goldiş“, Arad, România; Spitalul Clinic Judeţean de Urgenţă, Arad, RomâniaFacultatea de Medicină Universitatea de Vest „Vasile Goldiş“, Arad, România; Spitalul Clinic Judeţean de Urgenţă, Arad, RomâniaApolipoprotein (Apo) E plasma is a key factor of lipid metabolism. It is a surface component of triglycerides-rich lipoproteins, low-density lipoproteins (VLDL), chylomicron remnants and high-density lipoproteins (HDL). Most of the circulating ApoE is of hepatic origin, but can also be synthesized in the spleen, kidneys, lungs, muscle and central nervous system (6). The biological activity of ApoE depends on the polymorphism of the gene. ApoE is located on the long arm of chromosome 19, described as 3 alleles (ε2, ε3 and Ε4), which codifies 3 isoforms of ApoE: ε2, Ε3 and ε4 respectively. The clear, detailed definition of ApoE function in the 3 target locations – the hypothalamus, adipose tissue and plasma – can lead to an effective screening method based on the determination of the plasma lipid profile, ApoE becoming a readily detectable marker of metabolic disorder (11,12).https://revistemedicale.amaltea.ro/Romanian_MEDICAL_Journal/Revista_MEDICALA_ROMANA-2019-Nr.3/RMJ_2019_3_Art-09.pdfapolipoprotein emetabolic disordertype ii diabetes mellituslipid metabolismgenetic polymorphism |
| spellingShingle | Silviu Daniel Moldovan Romana Olivia Popeţiu Oana Lucia Amza Maria Puşchiţă APOLIPOPROTEIN E AND THE PROGRESSION OF RENAL NEPHROPATHY IN PACIENTS WITH DIABETES Romanian Medical Journal apolipoprotein e metabolic disorder type ii diabetes mellitus lipid metabolism genetic polymorphism |
| title | APOLIPOPROTEIN E AND THE PROGRESSION OF RENAL NEPHROPATHY IN PACIENTS WITH DIABETES |
| title_full | APOLIPOPROTEIN E AND THE PROGRESSION OF RENAL NEPHROPATHY IN PACIENTS WITH DIABETES |
| title_fullStr | APOLIPOPROTEIN E AND THE PROGRESSION OF RENAL NEPHROPATHY IN PACIENTS WITH DIABETES |
| title_full_unstemmed | APOLIPOPROTEIN E AND THE PROGRESSION OF RENAL NEPHROPATHY IN PACIENTS WITH DIABETES |
| title_short | APOLIPOPROTEIN E AND THE PROGRESSION OF RENAL NEPHROPATHY IN PACIENTS WITH DIABETES |
| title_sort | apolipoprotein e and the progression of renal nephropathy in pacients with diabetes |
| topic | apolipoprotein e metabolic disorder type ii diabetes mellitus lipid metabolism genetic polymorphism |
| url | https://revistemedicale.amaltea.ro/Romanian_MEDICAL_Journal/Revista_MEDICALA_ROMANA-2019-Nr.3/RMJ_2019_3_Art-09.pdf |
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