Shifting Developmental Trajectories During Critical Periods of Brain Formation
Critical periods of brain development are epochs of heightened plasticity driven by environmental influence necessary for normal brain function. Recent studies are beginning to shed light on the possibility that timely interventions during critical periods hold potential to reorient abnormal develop...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2020.00283/full |
| _version_ | 1818561899143364608 |
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| author | Nathalie Dehorter Isabel Del Pino |
| author_facet | Nathalie Dehorter Isabel Del Pino |
| author_sort | Nathalie Dehorter |
| collection | DOAJ |
| description | Critical periods of brain development are epochs of heightened plasticity driven by environmental influence necessary for normal brain function. Recent studies are beginning to shed light on the possibility that timely interventions during critical periods hold potential to reorient abnormal developmental trajectories in animal models of neurological and neuropsychiatric disorders. In this review, we re-examine the criteria defining critical periods, highlighting the recently discovered mechanisms of developmental plasticity in health and disease. In addition, we touch upon technological improvements for modeling critical periods in human-derived neural networks in vitro. These scientific advances associated with the use of developmental manipulations in the immature brain of animal models are the basic preclinical systems that will allow the future translatability of timely interventions into clinical applications for neurodevelopmental disorders such as intellectual disability, autism spectrum disorders (ASD) and schizophrenia. |
| first_indexed | 2024-12-14T00:56:44Z |
| format | Article |
| id | doaj.art-aa0cf25c7ca143ffb614e92d5b8fed23 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-14T00:56:44Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-aa0cf25c7ca143ffb614e92d5b8fed232022-12-21T23:23:31ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022020-09-011410.3389/fncel.2020.00283564167Shifting Developmental Trajectories During Critical Periods of Brain FormationNathalie Dehorter0Isabel Del Pino1Eccles Institute of Neuroscience, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, AustraliaPrincipe Felipe Research Center (Centro de Investigación Principe Felipe, CIPF), Valencia, SpainCritical periods of brain development are epochs of heightened plasticity driven by environmental influence necessary for normal brain function. Recent studies are beginning to shed light on the possibility that timely interventions during critical periods hold potential to reorient abnormal developmental trajectories in animal models of neurological and neuropsychiatric disorders. In this review, we re-examine the criteria defining critical periods, highlighting the recently discovered mechanisms of developmental plasticity in health and disease. In addition, we touch upon technological improvements for modeling critical periods in human-derived neural networks in vitro. These scientific advances associated with the use of developmental manipulations in the immature brain of animal models are the basic preclinical systems that will allow the future translatability of timely interventions into clinical applications for neurodevelopmental disorders such as intellectual disability, autism spectrum disorders (ASD) and schizophrenia.https://www.frontiersin.org/article/10.3389/fncel.2020.00283/fulldevelopmentplasticitycritical periodneurodevelopmental disordersbrain organoids |
| spellingShingle | Nathalie Dehorter Isabel Del Pino Shifting Developmental Trajectories During Critical Periods of Brain Formation Frontiers in Cellular Neuroscience development plasticity critical period neurodevelopmental disorders brain organoids |
| title | Shifting Developmental Trajectories During Critical Periods of Brain Formation |
| title_full | Shifting Developmental Trajectories During Critical Periods of Brain Formation |
| title_fullStr | Shifting Developmental Trajectories During Critical Periods of Brain Formation |
| title_full_unstemmed | Shifting Developmental Trajectories During Critical Periods of Brain Formation |
| title_short | Shifting Developmental Trajectories During Critical Periods of Brain Formation |
| title_sort | shifting developmental trajectories during critical periods of brain formation |
| topic | development plasticity critical period neurodevelopmental disorders brain organoids |
| url | https://www.frontiersin.org/article/10.3389/fncel.2020.00283/full |
| work_keys_str_mv | AT nathaliedehorter shiftingdevelopmentaltrajectoriesduringcriticalperiodsofbrainformation AT isabeldelpino shiftingdevelopmentaltrajectoriesduringcriticalperiodsofbrainformation |