The emerging studies on mesenchymal progenitors in the long bone
Abstract Mesenchymal progenitors (MPs) are considered to play vital roles in bone development, growth, bone turnover, and repair. In recent years, benefiting from advanced approaches such as single-cell sequence, lineage tracing, flow cytometry, and transplantation, multiple MPs are identified and c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13578-023-01039-x |
| _version_ | 1797806532145971200 |
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| author | Fangyuan Shen Xiaobin Huang Guangxu He Yu Shi |
| author_facet | Fangyuan Shen Xiaobin Huang Guangxu He Yu Shi |
| author_sort | Fangyuan Shen |
| collection | DOAJ |
| description | Abstract Mesenchymal progenitors (MPs) are considered to play vital roles in bone development, growth, bone turnover, and repair. In recent years, benefiting from advanced approaches such as single-cell sequence, lineage tracing, flow cytometry, and transplantation, multiple MPs are identified and characterized in several locations of bone, including perichondrium, growth plate, periosteum, endosteum, trabecular bone, and stromal compartment. However, although great discoveries about skeletal stem cells (SSCs) and progenitors are present, it is still largely obscure how the varied landscape of MPs from different residing sites diversely contribute to the further differentiation of osteoblasts, osteocytes, chondrocytes, and other stromal cells in their respective destiny sites during development and regeneration. Here we discuss recent findings on MPs’ origin, differentiation, and maintenance during long bone development and homeostasis, providing clues and models of how the MPs contribute to bone development and repair. |
| first_indexed | 2024-03-13T06:08:41Z |
| format | Article |
| id | doaj.art-aa0fd88306e644bba144866e33f3fcb0 |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-03-13T06:08:41Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-aa0fd88306e644bba144866e33f3fcb02023-06-11T11:26:30ZengBMCCell & Bioscience2045-37012023-06-0113112210.1186/s13578-023-01039-xThe emerging studies on mesenchymal progenitors in the long boneFangyuan Shen0Xiaobin Huang1Guangxu He2Yu Shi3State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityDepartment of Oral and Maxillofacial Surgery/Pharmacology, School of Dental Medicine, University of PennsylvaniaDepartment of Orthopedics, The Second Xiangya Hospital, Central South UniversityState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityAbstract Mesenchymal progenitors (MPs) are considered to play vital roles in bone development, growth, bone turnover, and repair. In recent years, benefiting from advanced approaches such as single-cell sequence, lineage tracing, flow cytometry, and transplantation, multiple MPs are identified and characterized in several locations of bone, including perichondrium, growth plate, periosteum, endosteum, trabecular bone, and stromal compartment. However, although great discoveries about skeletal stem cells (SSCs) and progenitors are present, it is still largely obscure how the varied landscape of MPs from different residing sites diversely contribute to the further differentiation of osteoblasts, osteocytes, chondrocytes, and other stromal cells in their respective destiny sites during development and regeneration. Here we discuss recent findings on MPs’ origin, differentiation, and maintenance during long bone development and homeostasis, providing clues and models of how the MPs contribute to bone development and repair.https://doi.org/10.1186/s13578-023-01039-xMesenchymal progenitorsBone developmentBone regeneration |
| spellingShingle | Fangyuan Shen Xiaobin Huang Guangxu He Yu Shi The emerging studies on mesenchymal progenitors in the long bone Cell & Bioscience Mesenchymal progenitors Bone development Bone regeneration |
| title | The emerging studies on mesenchymal progenitors in the long bone |
| title_full | The emerging studies on mesenchymal progenitors in the long bone |
| title_fullStr | The emerging studies on mesenchymal progenitors in the long bone |
| title_full_unstemmed | The emerging studies on mesenchymal progenitors in the long bone |
| title_short | The emerging studies on mesenchymal progenitors in the long bone |
| title_sort | emerging studies on mesenchymal progenitors in the long bone |
| topic | Mesenchymal progenitors Bone development Bone regeneration |
| url | https://doi.org/10.1186/s13578-023-01039-x |
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