Sweat in the pathogenesis of atopic dermatitis
Sweat is a transparent hypotonic body fluid made from eccrine sweat glands. Various ingredients contained in sweat are involved in a broad sense in skin homeostasis including temperature regulation, skin moisture, and immune functions. Thus, sweat plays a major role in maintaining skin homeostasis....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-10-01
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| Series: | Allergology International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893018300881 |
| _version_ | 1811293967250096128 |
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| author | Hiroyuki Murota Kosuke Yamaga Emi Ono Ichiro Katayama |
| author_facet | Hiroyuki Murota Kosuke Yamaga Emi Ono Ichiro Katayama |
| author_sort | Hiroyuki Murota |
| collection | DOAJ |
| description | Sweat is a transparent hypotonic body fluid made from eccrine sweat glands. Various ingredients contained in sweat are involved in a broad sense in skin homeostasis including temperature regulation, skin moisture, and immune functions. Thus, sweat plays a major role in maintaining skin homeostasis. Therefore, abnormal sweating easily compromises human health. For example, in atopic dermatitis (AD), perspiration stagnation accompanying sweat tube or sweat pore blockage, leakage of perspiration from the sweat gland to the outside tissue, and impaired secretion of sweat from the sweat gland are confirmed. In recent years, the hypothesis that atopic dermatitis is a sweat stasis syndrome has been clarified by the establishment of a sweat and sweat gland dynamic analysis technique. Secretion of sweat and leakage into tissues is caused by dermatitis and is thought to promote itching. Furthermore, from the metabolomic analysis of sweat of patients with atopic dermatitis, it was confirmed that the glucose concentration in AD sweat increased according to severity and skin phenotype, suggesting that elevated glucose affected the homeostasis of the skin. Multifaceted analyses of sweat from subjects with AD have revealed new aspects of the pathology, and appropriate measures to treat sweat can be expected to contribute to long-term control of AD. Keywords: Atopic dermatitis, Barrier, Metabolome, Sweat, Tight junction |
| first_indexed | 2024-04-13T05:09:19Z |
| format | Article |
| id | doaj.art-aa0fe0e57a8d4dcfb3d928f7550439d5 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-04-13T05:09:19Z |
| publishDate | 2018-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-aa0fe0e57a8d4dcfb3d928f7550439d52022-12-22T03:01:04ZengElsevierAllergology International1323-89302018-10-01674455459Sweat in the pathogenesis of atopic dermatitisHiroyuki Murota0Kosuke Yamaga1Emi Ono2Ichiro Katayama3Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan; Corresponding author. Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, Nagasaki 852-8501, Japan.Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanDepartment of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanDepartment of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanSweat is a transparent hypotonic body fluid made from eccrine sweat glands. Various ingredients contained in sweat are involved in a broad sense in skin homeostasis including temperature regulation, skin moisture, and immune functions. Thus, sweat plays a major role in maintaining skin homeostasis. Therefore, abnormal sweating easily compromises human health. For example, in atopic dermatitis (AD), perspiration stagnation accompanying sweat tube or sweat pore blockage, leakage of perspiration from the sweat gland to the outside tissue, and impaired secretion of sweat from the sweat gland are confirmed. In recent years, the hypothesis that atopic dermatitis is a sweat stasis syndrome has been clarified by the establishment of a sweat and sweat gland dynamic analysis technique. Secretion of sweat and leakage into tissues is caused by dermatitis and is thought to promote itching. Furthermore, from the metabolomic analysis of sweat of patients with atopic dermatitis, it was confirmed that the glucose concentration in AD sweat increased according to severity and skin phenotype, suggesting that elevated glucose affected the homeostasis of the skin. Multifaceted analyses of sweat from subjects with AD have revealed new aspects of the pathology, and appropriate measures to treat sweat can be expected to contribute to long-term control of AD. Keywords: Atopic dermatitis, Barrier, Metabolome, Sweat, Tight junctionhttp://www.sciencedirect.com/science/article/pii/S1323893018300881 |
| spellingShingle | Hiroyuki Murota Kosuke Yamaga Emi Ono Ichiro Katayama Sweat in the pathogenesis of atopic dermatitis Allergology International |
| title | Sweat in the pathogenesis of atopic dermatitis |
| title_full | Sweat in the pathogenesis of atopic dermatitis |
| title_fullStr | Sweat in the pathogenesis of atopic dermatitis |
| title_full_unstemmed | Sweat in the pathogenesis of atopic dermatitis |
| title_short | Sweat in the pathogenesis of atopic dermatitis |
| title_sort | sweat in the pathogenesis of atopic dermatitis |
| url | http://www.sciencedirect.com/science/article/pii/S1323893018300881 |
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