The clinical significance of serum HMGB1 in patients with lower extremity arteriosclerosis obliterans after interventional vascular restenosis
ObjectiveThis study explored the correlation between serum HMGB1 levels and postoperative vascular restenosis in patients with lower extremity arteriosclerosis obliterans (LEASO).MethodsA total of 362 patients LEASO who received vascular intervention were recruited in this study. Serum HMGB1 levels...
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.1031108/full |
| _version_ | 1828067618215428096 |
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| author | Bo Yang Zhang Xiaping Zhang Xiaping |
| author_facet | Bo Yang Zhang Xiaping Zhang Xiaping |
| author_sort | Bo Yang |
| collection | DOAJ |
| description | ObjectiveThis study explored the correlation between serum HMGB1 levels and postoperative vascular restenosis in patients with lower extremity arteriosclerosis obliterans (LEASO).MethodsA total of 362 patients LEASO who received vascular intervention were recruited in this study. Serum HMGB1 levels were measured by enzyme-linked immunosorbent assay. Logistic regression analysis was used to identify the influencing factors associated with vascular restenosis. The R procedure was used to create nomogram model. Receiver operating characteristic (ROC) analysis was used to determine the predictive value of serum HMGB1 and nomogram model for vascular restenosis.ResultsOf the 362 LEASO patients included, 103 (28.45%) developed restenosis within 6 months of postoperative follow-up. Postoperative HMGB1 levels were significantly higher in patients with restenosis compared to those with non-restenosis. Postoperative HMGB1 levels were significantly and positively correlated with the severity of postoperative restenosis (r = 0.819). The AUC of postoperative HMGB1 for the diagnosis of postoperative restenosis was 0.758 (95% CI: 0.703–0.812), with a sensitivity and specificity of 56.31% and 82.24%, respectively. Multivariate logistic regression analysis showed that diabetes, smoking, regular postoperative medication, increased fibrinogen, decreased red blood cells, increased hs-CRP, and increased postoperative HMGB1 were independently associated with postoperative restenosis in patients with LEASO. The C-index of the nomogram prediction model constructed based on the seven influencing factors mentioned above was 0.918. The nomogram model was significantly more predictive of postoperative restenosis in LEASO patients compared with a single postoperative HMGB1 (AUC: 0.918, 95% CI: 0.757–0.934).ConclusionPostoperative serum HMGB1 is an independent risk factor associated with postoperative vascular restenosis in patients with LEASO, and a novel nomogram model based on postoperative serum HMGB1 combined with clinical characteristics may help to accurately predict the risk of postoperative restenosis in patients with LEASO. |
| first_indexed | 2024-04-10T23:48:21Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-04-10T23:48:21Z |
| publishDate | 2023-01-01 |
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| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-aa1055e50e4d4137b71dd79eaa79c4ff2023-01-10T22:29:47ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2023-01-01910.3389/fsurg.2022.10311081031108The clinical significance of serum HMGB1 in patients with lower extremity arteriosclerosis obliterans after interventional vascular restenosisBo Yang0Zhang Xiaping1Zhang Xiaping2Department of Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, ChinaObjectiveThis study explored the correlation between serum HMGB1 levels and postoperative vascular restenosis in patients with lower extremity arteriosclerosis obliterans (LEASO).MethodsA total of 362 patients LEASO who received vascular intervention were recruited in this study. Serum HMGB1 levels were measured by enzyme-linked immunosorbent assay. Logistic regression analysis was used to identify the influencing factors associated with vascular restenosis. The R procedure was used to create nomogram model. Receiver operating characteristic (ROC) analysis was used to determine the predictive value of serum HMGB1 and nomogram model for vascular restenosis.ResultsOf the 362 LEASO patients included, 103 (28.45%) developed restenosis within 6 months of postoperative follow-up. Postoperative HMGB1 levels were significantly higher in patients with restenosis compared to those with non-restenosis. Postoperative HMGB1 levels were significantly and positively correlated with the severity of postoperative restenosis (r = 0.819). The AUC of postoperative HMGB1 for the diagnosis of postoperative restenosis was 0.758 (95% CI: 0.703–0.812), with a sensitivity and specificity of 56.31% and 82.24%, respectively. Multivariate logistic regression analysis showed that diabetes, smoking, regular postoperative medication, increased fibrinogen, decreased red blood cells, increased hs-CRP, and increased postoperative HMGB1 were independently associated with postoperative restenosis in patients with LEASO. The C-index of the nomogram prediction model constructed based on the seven influencing factors mentioned above was 0.918. The nomogram model was significantly more predictive of postoperative restenosis in LEASO patients compared with a single postoperative HMGB1 (AUC: 0.918, 95% CI: 0.757–0.934).ConclusionPostoperative serum HMGB1 is an independent risk factor associated with postoperative vascular restenosis in patients with LEASO, and a novel nomogram model based on postoperative serum HMGB1 combined with clinical characteristics may help to accurately predict the risk of postoperative restenosis in patients with LEASO.https://www.frontiersin.org/articles/10.3389/fsurg.2022.1031108/fulllower extremity arteriosclerosis obliteransvascular interventional therapyvascular restenosisHMGB1nomogram model |
| spellingShingle | Bo Yang Zhang Xiaping Zhang Xiaping The clinical significance of serum HMGB1 in patients with lower extremity arteriosclerosis obliterans after interventional vascular restenosis Frontiers in Surgery lower extremity arteriosclerosis obliterans vascular interventional therapy vascular restenosis HMGB1 nomogram model |
| title | The clinical significance of serum HMGB1 in patients with lower extremity arteriosclerosis obliterans after interventional vascular restenosis |
| title_full | The clinical significance of serum HMGB1 in patients with lower extremity arteriosclerosis obliterans after interventional vascular restenosis |
| title_fullStr | The clinical significance of serum HMGB1 in patients with lower extremity arteriosclerosis obliterans after interventional vascular restenosis |
| title_full_unstemmed | The clinical significance of serum HMGB1 in patients with lower extremity arteriosclerosis obliterans after interventional vascular restenosis |
| title_short | The clinical significance of serum HMGB1 in patients with lower extremity arteriosclerosis obliterans after interventional vascular restenosis |
| title_sort | clinical significance of serum hmgb1 in patients with lower extremity arteriosclerosis obliterans after interventional vascular restenosis |
| topic | lower extremity arteriosclerosis obliterans vascular interventional therapy vascular restenosis HMGB1 nomogram model |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.1031108/full |
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