Dorsal Striatal Circuits for Habits, Compulsions and Addictions
Here, we review the neural circuit bases of habits, compulsions, and addictions, behaviors which are all characterized by relatively automatic action performance. We discuss relevant studies, primarily from the rodent literature, and describe how major headway has been made in identifying the brain...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Systems Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnsys.2019.00028/full |
| _version_ | 1818946919284604928 |
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| author | David M. Lipton David M. Lipton Ben J. Gonzales Ami Citri Ami Citri Ami Citri |
| author_facet | David M. Lipton David M. Lipton Ben J. Gonzales Ami Citri Ami Citri Ami Citri |
| author_sort | David M. Lipton |
| collection | DOAJ |
| description | Here, we review the neural circuit bases of habits, compulsions, and addictions, behaviors which are all characterized by relatively automatic action performance. We discuss relevant studies, primarily from the rodent literature, and describe how major headway has been made in identifying the brain regions and neural cell types whose activity is modulated during the acquisition and performance of these automated behaviors. The dorsal striatum and cortical inputs to this structure have emerged as key players in the wider basal ganglia circuitry encoding behavioral automaticity, and changes in the activity of different neuronal cell-types in these brain regions have been shown to co-occur with the formation of automatic behaviors. We highlight how disordered functioning of these neural circuits can result in neuropsychiatric disorders, such as obsessive-compulsive disorder (OCD) and drug addiction. Finally, we discuss how the next phase of research in the field may benefit from integration of approaches for access to cells based on their genetic makeup, activity, connectivity and precise anatomical location. |
| first_indexed | 2024-12-20T08:22:39Z |
| format | Article |
| id | doaj.art-aa105ad093e948b4bd4bfb786086a90c |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-12-20T08:22:39Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-aa105ad093e948b4bd4bfb786086a90c2022-12-21T19:46:56ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372019-07-011310.3389/fnsys.2019.00028448921Dorsal Striatal Circuits for Habits, Compulsions and AddictionsDavid M. Lipton0David M. Lipton1Ben J. Gonzales2Ami Citri3Ami Citri4Ami Citri5Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, IsraelZuckerman Postdoctoral Scholar, Jerusalem, IsraelInstitute of Life Sciences, Edmond J. Safra Campus, Hebrew University of Jerusalem, Jerusalem, IsraelEdmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, IsraelInstitute of Life Sciences, Edmond J. Safra Campus, Hebrew University of Jerusalem, Jerusalem, IsraelProgram in Child and Brain Development, MaRS Centre, Canadian Institute for Advanced Research, Toronto, ON, CanadaHere, we review the neural circuit bases of habits, compulsions, and addictions, behaviors which are all characterized by relatively automatic action performance. We discuss relevant studies, primarily from the rodent literature, and describe how major headway has been made in identifying the brain regions and neural cell types whose activity is modulated during the acquisition and performance of these automated behaviors. The dorsal striatum and cortical inputs to this structure have emerged as key players in the wider basal ganglia circuitry encoding behavioral automaticity, and changes in the activity of different neuronal cell-types in these brain regions have been shown to co-occur with the formation of automatic behaviors. We highlight how disordered functioning of these neural circuits can result in neuropsychiatric disorders, such as obsessive-compulsive disorder (OCD) and drug addiction. Finally, we discuss how the next phase of research in the field may benefit from integration of approaches for access to cells based on their genetic makeup, activity, connectivity and precise anatomical location.https://www.frontiersin.org/article/10.3389/fnsys.2019.00028/fullhabitsgoal-directed behaviorstriatumprefrontal cortexdorsomedial striatumdorsolateral striatum |
| spellingShingle | David M. Lipton David M. Lipton Ben J. Gonzales Ami Citri Ami Citri Ami Citri Dorsal Striatal Circuits for Habits, Compulsions and Addictions Frontiers in Systems Neuroscience habits goal-directed behavior striatum prefrontal cortex dorsomedial striatum dorsolateral striatum |
| title | Dorsal Striatal Circuits for Habits, Compulsions and Addictions |
| title_full | Dorsal Striatal Circuits for Habits, Compulsions and Addictions |
| title_fullStr | Dorsal Striatal Circuits for Habits, Compulsions and Addictions |
| title_full_unstemmed | Dorsal Striatal Circuits for Habits, Compulsions and Addictions |
| title_short | Dorsal Striatal Circuits for Habits, Compulsions and Addictions |
| title_sort | dorsal striatal circuits for habits compulsions and addictions |
| topic | habits goal-directed behavior striatum prefrontal cortex dorsomedial striatum dorsolateral striatum |
| url | https://www.frontiersin.org/article/10.3389/fnsys.2019.00028/full |
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