Extracellular Juxtamembrane Motif Critical for TrkB Preformed Dimer and Activation

Extracellular Juxtamembrane Motif Critical for TrkB Preformed Dimer and Activation

Receptor tyrosine kinases are believed to be activated through ligand-induced dimerization. We now demonstrate that in cultured neurons, a substantial amount of endogenous TrkB, the receptor for brain-derived neurotrophic factor (BDNF), exists as an inactive preformed dimer, and the application of B...

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Bibliographic Details
Main Authors: Jianying Shen, Dang Sun, Jingyu Shao, Yanbo Chen, Keliang Pang, Wei Guo, Bai Lu
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
receptor tyrosine kinases
TrkB
preformed dimer
extracellular juxtamembrane motif
antibodies
brain-derived neurotrophic factor
Online Access:https://www.mdpi.com/2073-4409/8/8/932

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