Therapeutic Efficacy of Different Antidotal Mixtures Against Poisoning with GF-Agent in Mice
The toxicity of cyclohexyl methylphosphonofluoridate (GF-agent; cyclosarin) and therapeutic efficacy of four oximes (trimedoxime, methoxime, obidoxime and HI-6) in combination with atropine or benactyzine (BNZ) was studied in mice. The oxime therapy combined with anticholinergic drug was administere...
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| Format: | Article |
| Language: | English |
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Karolinum Press
2004-01-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/online_first/18059694.2018.99/ |
| _version_ | 1819226160802824192 |
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| author | Lucie Bartošová Gabriela Kunešová Kamil Kuča Josef Vachek |
| author_facet | Lucie Bartošová Gabriela Kunešová Kamil Kuča Josef Vachek |
| author_sort | Lucie Bartošová |
| collection | DOAJ |
| description | The toxicity of cyclohexyl methylphosphonofluoridate (GF-agent; cyclosarin) and therapeutic efficacy of four oximes (trimedoxime, methoxime, obidoxime and HI-6) in combination with atropine or benactyzine (BNZ) was studied in mice. The oxime therapy combined with anticholinergic drug was administered intramusculary (i.m.) 1 or 2 min after i.m. GF-agent challenge. All the drugs were applied in dose of 20% of LD50. Obidoxime and trimedoxime that were combined with atropine were less effective than methoxime and HI-6 in combination with BNZ when applied 2 minutes after GF-agent poisoning. When the drugs were administered 1 min after GF-agent challenge already, in case of methoxime, the faster application of therapy resulted in significantly higher protective ratio, while for obidoxime the therapeutic effectivity did not depend significantly on the seasonableness of therapeutic intervention. The present findings show that all four combinations of oxime with anticholinergic drug decrease the GF-agent toxicity more than twofold regardless of the time of treatment administration. |
| first_indexed | 2024-12-23T10:21:05Z |
| format | Article |
| id | doaj.art-aa123710931f42b09db017083ce62fe3 |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-12-23T10:21:05Z |
| publishDate | 2004-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-aa123710931f42b09db017083ce62fe32022-12-21T17:50:42ZengKarolinum PressActa Medica1211-42861805-96942004-01-0147424925110.14712/18059694.2018.99Therapeutic Efficacy of Different Antidotal Mixtures Against Poisoning with GF-Agent in MiceLucie Bartošová0Gabriela Kunešová1Kamil Kuča2Josef Vachek3Purkyně Military Medical Academy in Hradec Králové, Department of Toxicology, Hradec Králové, Czech RepublicPurkyně Military Medical Academy in Hradec Králové, Department of Toxicology, Hradec Králové, Czech RepublicPurkyně Military Medical Academy in Hradec Králové, Department of Toxicology, Hradec Králové, Czech RepublicPurkyně Military Medical Academy in Hradec Králové, Department of Toxicology, Hradec Králové, Czech RepublicThe toxicity of cyclohexyl methylphosphonofluoridate (GF-agent; cyclosarin) and therapeutic efficacy of four oximes (trimedoxime, methoxime, obidoxime and HI-6) in combination with atropine or benactyzine (BNZ) was studied in mice. The oxime therapy combined with anticholinergic drug was administered intramusculary (i.m.) 1 or 2 min after i.m. GF-agent challenge. All the drugs were applied in dose of 20% of LD50. Obidoxime and trimedoxime that were combined with atropine were less effective than methoxime and HI-6 in combination with BNZ when applied 2 minutes after GF-agent poisoning. When the drugs were administered 1 min after GF-agent challenge already, in case of methoxime, the faster application of therapy resulted in significantly higher protective ratio, while for obidoxime the therapeutic effectivity did not depend significantly on the seasonableness of therapeutic intervention. The present findings show that all four combinations of oxime with anticholinergic drug decrease the GF-agent toxicity more than twofold regardless of the time of treatment administration.https://actamedica.lfhk.cuni.cz/online_first/18059694.2018.99/GF-agentCyclosarinMethoximeObidoximeTrimedoximeHI-6 |
| spellingShingle | Lucie Bartošová Gabriela Kunešová Kamil Kuča Josef Vachek Therapeutic Efficacy of Different Antidotal Mixtures Against Poisoning with GF-Agent in Mice Acta Medica GF-agent Cyclosarin Methoxime Obidoxime Trimedoxime HI-6 |
| title | Therapeutic Efficacy of Different Antidotal Mixtures Against Poisoning with GF-Agent in Mice |
| title_full | Therapeutic Efficacy of Different Antidotal Mixtures Against Poisoning with GF-Agent in Mice |
| title_fullStr | Therapeutic Efficacy of Different Antidotal Mixtures Against Poisoning with GF-Agent in Mice |
| title_full_unstemmed | Therapeutic Efficacy of Different Antidotal Mixtures Against Poisoning with GF-Agent in Mice |
| title_short | Therapeutic Efficacy of Different Antidotal Mixtures Against Poisoning with GF-Agent in Mice |
| title_sort | therapeutic efficacy of different antidotal mixtures against poisoning with gf agent in mice |
| topic | GF-agent Cyclosarin Methoxime Obidoxime Trimedoxime HI-6 |
| url | https://actamedica.lfhk.cuni.cz/online_first/18059694.2018.99/ |
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