<i>Saccorhiza polyschides</i>—A Source of Natural Active Ingredients for Greener Skincare Formulations
The growing knowledge about the harmful effects caused by some synthetic ingredients present in skincare products has led to an extensive search for natural bioactives. Thus, this study aimed to investigate the dermatological potential of five fractions (F1–F5), obtained by a sequential extraction p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/19/6496 |
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| author | Patrícia Susano Joana Silva Celso Alves Alice Martins Susete Pinteus Helena Gaspar Márcia Inês Goettert Rui Pedrosa |
| author_facet | Patrícia Susano Joana Silva Celso Alves Alice Martins Susete Pinteus Helena Gaspar Márcia Inês Goettert Rui Pedrosa |
| author_sort | Patrícia Susano |
| collection | DOAJ |
| description | The growing knowledge about the harmful effects caused by some synthetic ingredients present in skincare products has led to an extensive search for natural bioactives. Thus, this study aimed to investigate the dermatological potential of five fractions (F1–F5), obtained by a sequential extraction procedure, from the brown seaweed <i>Saccorhiza polyschides</i>. The antioxidant (DPPH, FRAP, ORAC and TPC), anti-enzymatic (collagenase, elastase, hyaluronidase and tyrosinase), antimicrobial (<i>Staphylococcus epidermidis</i>, <i>Cutibacterium acnes</i> and <i>Malassezia furfur</i>), anti-inflammatory (nitric oxide, tumor necrosis factor-α, interleukin-6 and interleukin-10) and photoprotective (reactive oxygen species) properties of all fractions were evaluated. The ethyl acetate fraction (F3) displayed the highest antioxidant and photoprotective capacity, reducing ROS levels in UVA/B-exposed 3T3 fibroblasts, and the highest anti-enzymatic capacity against tyrosinase (IC<sub>50</sub> value: 89.1 µg/mL). The solid water-insoluble fraction (F5) revealed the greatest antimicrobial activity against <i>C. acnes</i> growth (IC<sub>50</sub> value: 12.4 µg/mL). Furthermore, all fractions demonstrated anti-inflammatory potential, reducing TNF-α and IL-6 levels in RAW 264.7 macrophages induced with lipopolysaccharides. Chemical analysis of the <i>S. polyschides</i> fractions by NMR revealed the presence of different classes of compounds, including lipids, polyphenols and sugars. The results highlight the potential of <i>S. polyschides</i> to be incorporated into new nature-based skincare products. |
| first_indexed | 2024-03-09T21:24:54Z |
| format | Article |
| id | doaj.art-aa129859f120431dae3c82b9cbf89c46 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T21:24:54Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-aa129859f120431dae3c82b9cbf89c462023-11-23T21:12:21ZengMDPI AGMolecules1420-30492022-10-012719649610.3390/molecules27196496<i>Saccorhiza polyschides</i>—A Source of Natural Active Ingredients for Greener Skincare FormulationsPatrícia Susano0Joana Silva1Celso Alves2Alice Martins3Susete Pinteus4Helena Gaspar5Márcia Inês Goettert6Rui Pedrosa7MARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, Polytechnic of Leiria, 2520-630 Peniche, PortugalMARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, Polytechnic of Leiria, 2520-630 Peniche, PortugalMARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, Polytechnic of Leiria, 2520-630 Peniche, PortugalMARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, Polytechnic of Leiria, 2520-630 Peniche, PortugalMARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, Polytechnic of Leiria, 2520-630 Peniche, PortugalMARE-Marine and Environmental Sciences Centre/ARNET-Aquatic Research Network, Polytechnic of Leiria, 2520-630 Peniche, PortugalCell Culture Laboratory, Postgraduate Programme in Biotechnology, University of Vale do Taquari-Univates, Lajeado 95914-014, RS, BrazilMARE/ARNET, ESTM, Polytechnic of Leiria, 2520-614 Peniche, PortugalThe growing knowledge about the harmful effects caused by some synthetic ingredients present in skincare products has led to an extensive search for natural bioactives. Thus, this study aimed to investigate the dermatological potential of five fractions (F1–F5), obtained by a sequential extraction procedure, from the brown seaweed <i>Saccorhiza polyschides</i>. The antioxidant (DPPH, FRAP, ORAC and TPC), anti-enzymatic (collagenase, elastase, hyaluronidase and tyrosinase), antimicrobial (<i>Staphylococcus epidermidis</i>, <i>Cutibacterium acnes</i> and <i>Malassezia furfur</i>), anti-inflammatory (nitric oxide, tumor necrosis factor-α, interleukin-6 and interleukin-10) and photoprotective (reactive oxygen species) properties of all fractions were evaluated. The ethyl acetate fraction (F3) displayed the highest antioxidant and photoprotective capacity, reducing ROS levels in UVA/B-exposed 3T3 fibroblasts, and the highest anti-enzymatic capacity against tyrosinase (IC<sub>50</sub> value: 89.1 µg/mL). The solid water-insoluble fraction (F5) revealed the greatest antimicrobial activity against <i>C. acnes</i> growth (IC<sub>50</sub> value: 12.4 µg/mL). Furthermore, all fractions demonstrated anti-inflammatory potential, reducing TNF-α and IL-6 levels in RAW 264.7 macrophages induced with lipopolysaccharides. Chemical analysis of the <i>S. polyschides</i> fractions by NMR revealed the presence of different classes of compounds, including lipids, polyphenols and sugars. The results highlight the potential of <i>S. polyschides</i> to be incorporated into new nature-based skincare products.https://www.mdpi.com/1420-3049/27/19/6496bioactive compoundsbrown macroalgaedermatological potentialoxidative stressanti-inflammatory activity |
| spellingShingle | Patrícia Susano Joana Silva Celso Alves Alice Martins Susete Pinteus Helena Gaspar Márcia Inês Goettert Rui Pedrosa <i>Saccorhiza polyschides</i>—A Source of Natural Active Ingredients for Greener Skincare Formulations Molecules bioactive compounds brown macroalgae dermatological potential oxidative stress anti-inflammatory activity |
| title | <i>Saccorhiza polyschides</i>—A Source of Natural Active Ingredients for Greener Skincare Formulations |
| title_full | <i>Saccorhiza polyschides</i>—A Source of Natural Active Ingredients for Greener Skincare Formulations |
| title_fullStr | <i>Saccorhiza polyschides</i>—A Source of Natural Active Ingredients for Greener Skincare Formulations |
| title_full_unstemmed | <i>Saccorhiza polyschides</i>—A Source of Natural Active Ingredients for Greener Skincare Formulations |
| title_short | <i>Saccorhiza polyschides</i>—A Source of Natural Active Ingredients for Greener Skincare Formulations |
| title_sort | i saccorhiza polyschides i a source of natural active ingredients for greener skincare formulations |
| topic | bioactive compounds brown macroalgae dermatological potential oxidative stress anti-inflammatory activity |
| url | https://www.mdpi.com/1420-3049/27/19/6496 |
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