Early menopause is associated with abnormal diastolic function and poor clinical outcomes in women with suspected angina
Abstract Early identification of women at high risk for cardiovascular diseases (CVD), with subsequent monitoring, will allow for improved clinical outcomes and generally better quality of life. This study aimed to identify the associations between early menopause, abnormal diastolic function, and c...
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| Format: | Article |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-57058-2 |
| _version_ | 1797259301714132992 |
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| author | SungA Bae Seong-Mi Park So Ree Kim Mi-Na Kim Dong-Hyuk Cho Hee-Dong Kim Hyun Ju Yoon Myung-A Kim Hack-Lyoung Kim Kyung-Soon Hong Mi-Seung Shin Jin-Ok Jeong Wan-Joo Shim |
| author_facet | SungA Bae Seong-Mi Park So Ree Kim Mi-Na Kim Dong-Hyuk Cho Hee-Dong Kim Hyun Ju Yoon Myung-A Kim Hack-Lyoung Kim Kyung-Soon Hong Mi-Seung Shin Jin-Ok Jeong Wan-Joo Shim |
| author_sort | SungA Bae |
| collection | DOAJ |
| description | Abstract Early identification of women at high risk for cardiovascular diseases (CVD), with subsequent monitoring, will allow for improved clinical outcomes and generally better quality of life. This study aimed to identify the associations between early menopause, abnormal diastolic function, and clinical outcomes. This retrospective study included 795 menopausal women from is a nationwide, multicenter, registry of patients with suspected angina visiting outpatient clinic. The patients into two groups: early and normal menopause (menopausal age ≤ 45 and > 45 years, respectively). If participants met > 50% of the diastolic function criteria, they were classified as having normal diastolic function. Multivariable-adjusted Cox models were used to test associations between menopausal age and clinical outcomes including the incidence of major adverse cardiovascular events (MACE), over a median follow-up period of 771 days. Early menopause was associated with increased waist circumference (p = 0.001), diabetes prevalence (p = 0.003), obstructive coronary artery disease (p = 0.005), abnormal diastolic function (p = 0.003) and greater incidences of MACE, acute coronary syndrome, and hospitalization for heart failure. In patients with abnormal diastolic function, early menopause increased MACE risk significantly, with no significant difference in normal diastolic function. These findings highlight early menopause and abnormal diastolic function as being potential risk markers in women for midlife CVD events. |
| first_indexed | 2024-04-24T23:07:15Z |
| format | Article |
| id | doaj.art-aa135caee384482db9543df978aa7f80 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T23:07:15Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-aa135caee384482db9543df978aa7f802024-03-17T12:25:39ZengNature PortfolioScientific Reports2045-23222024-03-0114111010.1038/s41598-024-57058-2Early menopause is associated with abnormal diastolic function and poor clinical outcomes in women with suspected anginaSungA Bae0Seong-Mi Park1So Ree Kim2Mi-Na Kim3Dong-Hyuk Cho4Hee-Dong Kim5Hyun Ju Yoon6Myung-A Kim7Hack-Lyoung Kim8Kyung-Soon Hong9Mi-Seung Shin10Jin-Ok Jeong11Wan-Joo Shim12Department of Cardiology, Yongin Severance Hospital, Yonsei University College of MedicineDivision of Cardiology, Department of Internal Medicine, Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University Anam HospitalDepartment of Cardiology, Chonnam National University HospitalDepartment of Cardiology, Seoul National University Boramae Medical CenterDepartment of Cardiology, Seoul National University Boramae Medical CenterDepartment of Cardiology, Hallym University Medical CenterDepartment of Cardiology, Gachon University Gil Medical CenterDepartment of Cardiology, Chungnam National University HospitalDivision of Cardiology, Department of Internal Medicine, Korea University Anam HospitalAbstract Early identification of women at high risk for cardiovascular diseases (CVD), with subsequent monitoring, will allow for improved clinical outcomes and generally better quality of life. This study aimed to identify the associations between early menopause, abnormal diastolic function, and clinical outcomes. This retrospective study included 795 menopausal women from is a nationwide, multicenter, registry of patients with suspected angina visiting outpatient clinic. The patients into two groups: early and normal menopause (menopausal age ≤ 45 and > 45 years, respectively). If participants met > 50% of the diastolic function criteria, they were classified as having normal diastolic function. Multivariable-adjusted Cox models were used to test associations between menopausal age and clinical outcomes including the incidence of major adverse cardiovascular events (MACE), over a median follow-up period of 771 days. Early menopause was associated with increased waist circumference (p = 0.001), diabetes prevalence (p = 0.003), obstructive coronary artery disease (p = 0.005), abnormal diastolic function (p = 0.003) and greater incidences of MACE, acute coronary syndrome, and hospitalization for heart failure. In patients with abnormal diastolic function, early menopause increased MACE risk significantly, with no significant difference in normal diastolic function. These findings highlight early menopause and abnormal diastolic function as being potential risk markers in women for midlife CVD events.https://doi.org/10.1038/s41598-024-57058-2 |
| spellingShingle | SungA Bae Seong-Mi Park So Ree Kim Mi-Na Kim Dong-Hyuk Cho Hee-Dong Kim Hyun Ju Yoon Myung-A Kim Hack-Lyoung Kim Kyung-Soon Hong Mi-Seung Shin Jin-Ok Jeong Wan-Joo Shim Early menopause is associated with abnormal diastolic function and poor clinical outcomes in women with suspected angina Scientific Reports |
| title | Early menopause is associated with abnormal diastolic function and poor clinical outcomes in women with suspected angina |
| title_full | Early menopause is associated with abnormal diastolic function and poor clinical outcomes in women with suspected angina |
| title_fullStr | Early menopause is associated with abnormal diastolic function and poor clinical outcomes in women with suspected angina |
| title_full_unstemmed | Early menopause is associated with abnormal diastolic function and poor clinical outcomes in women with suspected angina |
| title_short | Early menopause is associated with abnormal diastolic function and poor clinical outcomes in women with suspected angina |
| title_sort | early menopause is associated with abnormal diastolic function and poor clinical outcomes in women with suspected angina |
| url | https://doi.org/10.1038/s41598-024-57058-2 |
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