Inverse electron demand Diels-Alder reaction in total synthesis of bioactive natural products
Among the various chemical reactions implemented during the total syntheses, the Inverse Electron Demand Diels-Alder Reaction (IEDDAR) is one of the crucial transformations utilized in building the complexity of bioactive natural products and drug-like molecules. Keeping in view the growing interest...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Tetrahedron Chem |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666951X24000056 |
| _version_ | 1827310598998720512 |
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| author | Showkat Rashid Waseem I. Lone Auqib Rashid Bilal A. Bhat |
| author_facet | Showkat Rashid Waseem I. Lone Auqib Rashid Bilal A. Bhat |
| author_sort | Showkat Rashid |
| collection | DOAJ |
| description | Among the various chemical reactions implemented during the total syntheses, the Inverse Electron Demand Diels-Alder Reaction (IEDDAR) is one of the crucial transformations utilized in building the complexity of bioactive natural products and drug-like molecules. Keeping in view the growing interest in harnessing the potential of this reaction, an overview of natural products that have been assembled through IEDDAR in the last 13 years (2011–2023) is presented through a selection of around 30 natural product total syntheses. In each case, the synthesis is presented schematically and the crucial IEDDAR step is duly highlighted in color. Additionally, wherever necessary, key structural features, characterization, biogenesis and biological activity attributes of the bioactive natural products are also discussed. |
| first_indexed | 2024-03-07T21:52:35Z |
| format | Article |
| id | doaj.art-aa150125251c42aab08b26ccba95356b |
| institution | Directory Open Access Journal |
| issn | 2666-951X |
| language | English |
| last_indexed | 2024-04-24T20:02:47Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Tetrahedron Chem |
| spelling | doaj.art-aa150125251c42aab08b26ccba95356b2024-03-24T07:02:06ZengElsevierTetrahedron Chem2666-951X2024-03-019100066Inverse electron demand Diels-Alder reaction in total synthesis of bioactive natural productsShowkat Rashid0Waseem I. Lone1Auqib Rashid2Bilal A. Bhat3Natural Products & Medicinal Chemistry Division, Indian Institute of Integrative Medicine (IIIM), Jammu, Jammu and Kashmir, 180001, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, 201002, India; Corresponding author. Natural Products & Medicinal Chemistry, Indian Institute of Integrative Medicine (IIIM), Jammu, Jammu and Kashmir, 180001, India.Natural Products & Medicinal Chemistry Division, Indian Institute of Integrative Medicine (IIIM), Jammu, Jammu and Kashmir, 180001, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, 201002, IndiaNatural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Sanat Nagar, Srinagar, 190005, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, 201002, IndiaNatural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Sanat Nagar, Srinagar, 190005, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, 201002, India; Corresponding author. Natural Products and Medicinal Chemistry, CSIR-Indian Institute of Integrative Medicine, Sanat Nagar-Srinagar, 190005, India.Among the various chemical reactions implemented during the total syntheses, the Inverse Electron Demand Diels-Alder Reaction (IEDDAR) is one of the crucial transformations utilized in building the complexity of bioactive natural products and drug-like molecules. Keeping in view the growing interest in harnessing the potential of this reaction, an overview of natural products that have been assembled through IEDDAR in the last 13 years (2011–2023) is presented through a selection of around 30 natural product total syntheses. In each case, the synthesis is presented schematically and the crucial IEDDAR step is duly highlighted in color. Additionally, wherever necessary, key structural features, characterization, biogenesis and biological activity attributes of the bioactive natural products are also discussed.http://www.sciencedirect.com/science/article/pii/S2666951X24000056 |
| spellingShingle | Showkat Rashid Waseem I. Lone Auqib Rashid Bilal A. Bhat Inverse electron demand Diels-Alder reaction in total synthesis of bioactive natural products Tetrahedron Chem |
| title | Inverse electron demand Diels-Alder reaction in total synthesis of bioactive natural products |
| title_full | Inverse electron demand Diels-Alder reaction in total synthesis of bioactive natural products |
| title_fullStr | Inverse electron demand Diels-Alder reaction in total synthesis of bioactive natural products |
| title_full_unstemmed | Inverse electron demand Diels-Alder reaction in total synthesis of bioactive natural products |
| title_short | Inverse electron demand Diels-Alder reaction in total synthesis of bioactive natural products |
| title_sort | inverse electron demand diels alder reaction in total synthesis of bioactive natural products |
| url | http://www.sciencedirect.com/science/article/pii/S2666951X24000056 |
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