Acute effects of whey protein, alone and mixed with other macronutrients, on blood pressure and heart rate in older men
Abstract Background Caloric supplements are increasingly used by older people, aiming to increase their daily protein intake. These high caloric drinks, rich in glucose and whey-protein in particular, may result in potential harmful decreases in blood pressure (BP). The effect of ingesting whey-prot...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-022-03213-1 |
| _version_ | 1818234797991919616 |
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| author | Avneet Oberoi Caroline Giezenaar Kylie Lange Karen L. Jones Michael Horowitz Ian Chapman Stijn Soenen |
| author_facet | Avneet Oberoi Caroline Giezenaar Kylie Lange Karen L. Jones Michael Horowitz Ian Chapman Stijn Soenen |
| author_sort | Avneet Oberoi |
| collection | DOAJ |
| description | Abstract Background Caloric supplements are increasingly used by older people, aiming to increase their daily protein intake. These high caloric drinks, rich in glucose and whey-protein in particular, may result in potential harmful decreases in blood pressure (BP). The effect of ingesting whey-protein with glucose and fat on BP is unknown. It has also been assumed that the maximum fall in systolic blood pressure occurs within 2 h of a meal. Methods This study aimed to determine in older men, the effects of whey-protein, alone and mixed with other macronutrients, on systolic (SBP) and diastolic (DBP) blood pressure and heart rate (HR) in older men for 3 h. Thirteen older men (age 75 ± 2yrs; body mass index (BMI) 25.6 ± 0.6 kg/m2) ingested a drink on separate study days: (i) 70 g whey-protein (P280); (ii) 14 g whey-protein, 28 g carbohydrate, 12.4 g fat (M280); (iii) 70 g whey-protein, 28 g carbohydrate, 12.4 g fat (M504); or (iv) a non-caloric control drink (C). Results SBP decreased after all three nutrient drinks compared to the C, with the greatest reduction after the M504 drink (P = 0.008). Maximal decreases in SBP (C: -14 ± 2 mmHg, P280: -22 ± 2 mmHg, M280: -22 ± 4 mmHg, M504: -24 ± 3 mmHg) occurred about 2 h after drink ingestion and this fall was sustained thereafter (120-180 min: P280 and M504 vs. C P < 0.05). Maximum DBP decreases and HR increases occurred after M504, with no differences between the effects of the P280 and M280 drinks. Conclusions The effects of whey-protein containing drinks to lower BP and increase HR appear to be primarily dependent on their energy content rather than macronutrient composition and may persist for at least 3 h after ingestion,. Pure whey-protein drinks may represent the best approach to maximize protein intake without increasing the potential for deleterious BP falls in older people. Trial registration ACTRN12614000846628 , 14/03/2019. |
| first_indexed | 2024-12-12T11:43:48Z |
| format | Article |
| id | doaj.art-aa15a2f5ade7444898a53235d7220f03 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-12T11:43:48Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-aa15a2f5ade7444898a53235d7220f032022-12-22T00:25:29ZengBMCBMC Geriatrics1471-23182022-06-012211610.1186/s12877-022-03213-1Acute effects of whey protein, alone and mixed with other macronutrients, on blood pressure and heart rate in older menAvneet Oberoi0Caroline Giezenaar1Kylie Lange2Karen L. Jones3Michael Horowitz4Ian Chapman5Stijn Soenen6Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Royal Adelaide HospitalRiddett Institute, Massey UniversityAdelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Royal Adelaide HospitalAdelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Royal Adelaide HospitalAdelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Royal Adelaide HospitalAdelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Royal Adelaide HospitalFaculty of Health Sciences and Medicine, Bond UniversityAbstract Background Caloric supplements are increasingly used by older people, aiming to increase their daily protein intake. These high caloric drinks, rich in glucose and whey-protein in particular, may result in potential harmful decreases in blood pressure (BP). The effect of ingesting whey-protein with glucose and fat on BP is unknown. It has also been assumed that the maximum fall in systolic blood pressure occurs within 2 h of a meal. Methods This study aimed to determine in older men, the effects of whey-protein, alone and mixed with other macronutrients, on systolic (SBP) and diastolic (DBP) blood pressure and heart rate (HR) in older men for 3 h. Thirteen older men (age 75 ± 2yrs; body mass index (BMI) 25.6 ± 0.6 kg/m2) ingested a drink on separate study days: (i) 70 g whey-protein (P280); (ii) 14 g whey-protein, 28 g carbohydrate, 12.4 g fat (M280); (iii) 70 g whey-protein, 28 g carbohydrate, 12.4 g fat (M504); or (iv) a non-caloric control drink (C). Results SBP decreased after all three nutrient drinks compared to the C, with the greatest reduction after the M504 drink (P = 0.008). Maximal decreases in SBP (C: -14 ± 2 mmHg, P280: -22 ± 2 mmHg, M280: -22 ± 4 mmHg, M504: -24 ± 3 mmHg) occurred about 2 h after drink ingestion and this fall was sustained thereafter (120-180 min: P280 and M504 vs. C P < 0.05). Maximum DBP decreases and HR increases occurred after M504, with no differences between the effects of the P280 and M280 drinks. Conclusions The effects of whey-protein containing drinks to lower BP and increase HR appear to be primarily dependent on their energy content rather than macronutrient composition and may persist for at least 3 h after ingestion,. Pure whey-protein drinks may represent the best approach to maximize protein intake without increasing the potential for deleterious BP falls in older people. Trial registration ACTRN12614000846628 , 14/03/2019.https://doi.org/10.1186/s12877-022-03213-1AgingDietWhey proteinBlood pressureHeart rate |
| spellingShingle | Avneet Oberoi Caroline Giezenaar Kylie Lange Karen L. Jones Michael Horowitz Ian Chapman Stijn Soenen Acute effects of whey protein, alone and mixed with other macronutrients, on blood pressure and heart rate in older men BMC Geriatrics Aging Diet Whey protein Blood pressure Heart rate |
| title | Acute effects of whey protein, alone and mixed with other macronutrients, on blood pressure and heart rate in older men |
| title_full | Acute effects of whey protein, alone and mixed with other macronutrients, on blood pressure and heart rate in older men |
| title_fullStr | Acute effects of whey protein, alone and mixed with other macronutrients, on blood pressure and heart rate in older men |
| title_full_unstemmed | Acute effects of whey protein, alone and mixed with other macronutrients, on blood pressure and heart rate in older men |
| title_short | Acute effects of whey protein, alone and mixed with other macronutrients, on blood pressure and heart rate in older men |
| title_sort | acute effects of whey protein alone and mixed with other macronutrients on blood pressure and heart rate in older men |
| topic | Aging Diet Whey protein Blood pressure Heart rate |
| url | https://doi.org/10.1186/s12877-022-03213-1 |
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