Progress in constructing functional coacervate systems using microfluidics
Abstract Coacervates formed by liquid‐liquid phase separation play significant roles in a variety of intracellular and extracellular biological processes. Recently, substantial efforts have been invested in creating protocells using coacervates. Microfluidic technology has rapidly gained prominence...
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | BMEMat |
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| Online Access: | https://doi.org/10.1002/bmm2.12058 |
| _version_ | 1797289132052971520 |
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| author | Yuhao Geng Jing Yu |
| author_facet | Yuhao Geng Jing Yu |
| author_sort | Yuhao Geng |
| collection | DOAJ |
| description | Abstract Coacervates formed by liquid‐liquid phase separation play significant roles in a variety of intracellular and extracellular biological processes. Recently, substantial efforts have been invested in creating protocells using coacervates. Microfluidic technology has rapidly gained prominence in this area due to its capability to construct monodisperse and stable coacervate droplets. This review highlights recent advancements in utilizing microfluidic devices to construct coacervate‐core‐vesicle (COV) systems. These COV systems can be employed to realize the sequestration and release of biomolecules as well as to control enzymatic reactions within the coacervate systems in a spatiotemporal manner. Lastly, we delve into the current challenges and opportunities related to the development of functional coacervate systems based on microfluidic technology. |
| first_indexed | 2024-03-07T18:59:37Z |
| format | Article |
| id | doaj.art-aa181ccc48594fcb91a219af1170f167 |
| institution | Directory Open Access Journal |
| issn | 2751-7446 |
| language | English |
| last_indexed | 2024-03-07T18:59:37Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | BMEMat |
| spelling | doaj.art-aa181ccc48594fcb91a219af1170f1672024-03-01T16:48:53ZengWileyBMEMat2751-74462024-02-0121n/an/a10.1002/bmm2.12058Progress in constructing functional coacervate systems using microfluidicsYuhao Geng0Jing Yu1School of Materials Science & Engineering Nanyang Technological University (NTU) Singapore SingaporeSchool of Materials Science & Engineering Nanyang Technological University (NTU) Singapore SingaporeAbstract Coacervates formed by liquid‐liquid phase separation play significant roles in a variety of intracellular and extracellular biological processes. Recently, substantial efforts have been invested in creating protocells using coacervates. Microfluidic technology has rapidly gained prominence in this area due to its capability to construct monodisperse and stable coacervate droplets. This review highlights recent advancements in utilizing microfluidic devices to construct coacervate‐core‐vesicle (COV) systems. These COV systems can be employed to realize the sequestration and release of biomolecules as well as to control enzymatic reactions within the coacervate systems in a spatiotemporal manner. Lastly, we delve into the current challenges and opportunities related to the development of functional coacervate systems based on microfluidic technology.https://doi.org/10.1002/bmm2.12058coacervate‐core‐vesicle (COV) systemsliquid‐liquid phase separationmicrofluidicssynthetic cells |
| spellingShingle | Yuhao Geng Jing Yu Progress in constructing functional coacervate systems using microfluidics BMEMat coacervate‐core‐vesicle (COV) systems liquid‐liquid phase separation microfluidics synthetic cells |
| title | Progress in constructing functional coacervate systems using microfluidics |
| title_full | Progress in constructing functional coacervate systems using microfluidics |
| title_fullStr | Progress in constructing functional coacervate systems using microfluidics |
| title_full_unstemmed | Progress in constructing functional coacervate systems using microfluidics |
| title_short | Progress in constructing functional coacervate systems using microfluidics |
| title_sort | progress in constructing functional coacervate systems using microfluidics |
| topic | coacervate‐core‐vesicle (COV) systems liquid‐liquid phase separation microfluidics synthetic cells |
| url | https://doi.org/10.1002/bmm2.12058 |
| work_keys_str_mv | AT yuhaogeng progressinconstructingfunctionalcoacervatesystemsusingmicrofluidics AT jingyu progressinconstructingfunctionalcoacervatesystemsusingmicrofluidics |