Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure
Abstract Background Northern Senegal is a zone of very low malaria transmission, with an annual incidence of < 5/1000 inhabitants. This area, where the Senegal National Malaria Control Programme has initiated elimination activities, hosts Fulani, nomadic, pastoralists that spend the dry season in...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12936-020-3114-2 |
| _version_ | 1819054916017061888 |
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| author | Mame Cheikh Seck Julie Thwing Aida Sadikh Badiane Eric Rogier Fatou Ba Fall Pape Ibrahima Ndiaye Khadim Diongue Moustapha Mbow Mouhamadou Ndiaye Mamadou Alpha Diallo Jules François Gomis Aminata Mbaye Tolla Ndiaye Aminata Gaye Mohamad Sy Awa Bineta Déme Yaye Die Ndiaye Daouda Ndiaye |
| author_facet | Mame Cheikh Seck Julie Thwing Aida Sadikh Badiane Eric Rogier Fatou Ba Fall Pape Ibrahima Ndiaye Khadim Diongue Moustapha Mbow Mouhamadou Ndiaye Mamadou Alpha Diallo Jules François Gomis Aminata Mbaye Tolla Ndiaye Aminata Gaye Mohamad Sy Awa Bineta Déme Yaye Die Ndiaye Daouda Ndiaye |
| author_sort | Mame Cheikh Seck |
| collection | DOAJ |
| description | Abstract Background Northern Senegal is a zone of very low malaria transmission, with an annual incidence of < 5/1000 inhabitants. This area, where the Senegal National Malaria Control Programme has initiated elimination activities, hosts Fulani, nomadic, pastoralists that spend the dry season in the south where malaria incidence is higher (150–450/1000 inhabitants) and return to the north with the first rains. Previous research demonstrated parasite prevalence of < 1% in this Fulani population upon return from the south, similar to that documented in the north in cross-sectional surveys. Methods A modified snowball sampling survey of nomadic pastoralists was conducted in five districts in northern Senegal during September and October 2014. Demographic information and dried blood spots were collected. Multiplex bead-based assays were used to assess antibody responses to merozoite surface protein (MSP-119) antigen of the four primary Plasmodium species, as well as circumsporozoite protein (CSP) and liver stage antigen (LSA-1) of Plasmodium falciparum. Results In the five study districts, 1472 individuals were enrolled, with a median age of 22 years (range 1 to 80 years). Thirty-two percent of subjects were under 14 years and 57% were male. The overall seroprevalence of P. falciparum MSP-119, CSP and LSA-1 antibodies were 45, 12 and 5%, respectively. Plasmodium falciparum MSP-119 antibody responses increased significantly with age in all study areas, and were significantly higher among males. The highest seroprevalence to P. falciparum antigens was observed in the Kanel district (63%) and the lowest observed in Podor (28%). Low seroprevalence was observed for non-falciparum species in all the study sites: 0.4, 0.7 and 1.8%, respectively, for Plasmodium ovale, Plasmodium vivax and Plasmodium malariae MSP-1. Antibody responses to P. vivax were observed in all study sites except Kanel. Conclusion Prevalence of P. falciparum MSP-119 antibodies and increases by study participant age provided data for low levels of exposure among this transient nomadic population. In addition, antibody responses to P. falciparum short half-life markers (CSP and LSA-1) and non-falciparum species were low. Further investigations are needed to understand the exposure of the Fulani population to P. vivax. |
| first_indexed | 2024-12-21T12:59:13Z |
| format | Article |
| id | doaj.art-aa1a2069f57343d79c56268a5143bf47 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-21T12:59:13Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-aa1a2069f57343d79c56268a5143bf472022-12-21T19:03:15ZengBMCMalaria Journal1475-28752020-01-0119111010.1186/s12936-020-3114-2Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposureMame Cheikh Seck0Julie Thwing1Aida Sadikh Badiane2Eric Rogier3Fatou Ba Fall4Pape Ibrahima Ndiaye5Khadim Diongue6Moustapha Mbow7Mouhamadou Ndiaye8Mamadou Alpha Diallo9Jules François Gomis10Aminata Mbaye11Tolla Ndiaye12Aminata Gaye13Mohamad Sy14Awa Bineta Déme15Yaye Die Ndiaye16Daouda Ndiaye17Department of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop UniversityMalaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and PreventionDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop UniversityMalaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and PreventionSenegal National Malaria Control ProgrammeLaboratory of Parasitology, Aristide Le Dantec Teaching HospitalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop UniversityDepartment of Immunology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop UniversityDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop UniversityLaboratory of Parasitology, Aristide Le Dantec Teaching HospitalLaboratory of Parasitology, Aristide Le Dantec Teaching HospitalLaboratory of Parasitology, Aristide Le Dantec Teaching HospitalLaboratory of Parasitology, Aristide Le Dantec Teaching HospitalLaboratory of Parasitology, Aristide Le Dantec Teaching HospitalLaboratory of Parasitology, Aristide Le Dantec Teaching HospitalLaboratory of Parasitology, Aristide Le Dantec Teaching HospitalLaboratory of Parasitology, Aristide Le Dantec Teaching HospitalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop UniversityAbstract Background Northern Senegal is a zone of very low malaria transmission, with an annual incidence of < 5/1000 inhabitants. This area, where the Senegal National Malaria Control Programme has initiated elimination activities, hosts Fulani, nomadic, pastoralists that spend the dry season in the south where malaria incidence is higher (150–450/1000 inhabitants) and return to the north with the first rains. Previous research demonstrated parasite prevalence of < 1% in this Fulani population upon return from the south, similar to that documented in the north in cross-sectional surveys. Methods A modified snowball sampling survey of nomadic pastoralists was conducted in five districts in northern Senegal during September and October 2014. Demographic information and dried blood spots were collected. Multiplex bead-based assays were used to assess antibody responses to merozoite surface protein (MSP-119) antigen of the four primary Plasmodium species, as well as circumsporozoite protein (CSP) and liver stage antigen (LSA-1) of Plasmodium falciparum. Results In the five study districts, 1472 individuals were enrolled, with a median age of 22 years (range 1 to 80 years). Thirty-two percent of subjects were under 14 years and 57% were male. The overall seroprevalence of P. falciparum MSP-119, CSP and LSA-1 antibodies were 45, 12 and 5%, respectively. Plasmodium falciparum MSP-119 antibody responses increased significantly with age in all study areas, and were significantly higher among males. The highest seroprevalence to P. falciparum antigens was observed in the Kanel district (63%) and the lowest observed in Podor (28%). Low seroprevalence was observed for non-falciparum species in all the study sites: 0.4, 0.7 and 1.8%, respectively, for Plasmodium ovale, Plasmodium vivax and Plasmodium malariae MSP-1. Antibody responses to P. vivax were observed in all study sites except Kanel. Conclusion Prevalence of P. falciparum MSP-119 antibodies and increases by study participant age provided data for low levels of exposure among this transient nomadic population. In addition, antibody responses to P. falciparum short half-life markers (CSP and LSA-1) and non-falciparum species were low. Further investigations are needed to understand the exposure of the Fulani population to P. vivax.https://doi.org/10.1186/s12936-020-3114-2MalariaMSP-119CSPLSA-1AntibodiesPlasmodium |
| spellingShingle | Mame Cheikh Seck Julie Thwing Aida Sadikh Badiane Eric Rogier Fatou Ba Fall Pape Ibrahima Ndiaye Khadim Diongue Moustapha Mbow Mouhamadou Ndiaye Mamadou Alpha Diallo Jules François Gomis Aminata Mbaye Tolla Ndiaye Aminata Gaye Mohamad Sy Awa Bineta Déme Yaye Die Ndiaye Daouda Ndiaye Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure Malaria Journal Malaria MSP-119 CSP LSA-1 Antibodies Plasmodium |
| title | Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure |
| title_full | Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure |
| title_fullStr | Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure |
| title_full_unstemmed | Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure |
| title_short | Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure |
| title_sort | analysis of anti plasmodium igg profiles among fulani nomadic pastoralists in northern senegal to assess malaria exposure |
| topic | Malaria MSP-119 CSP LSA-1 Antibodies Plasmodium |
| url | https://doi.org/10.1186/s12936-020-3114-2 |
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