A Practical and Analytical Comparative Study of Gel-Based Top-Down and Gel-Free Bottom-Up Proteomics Including Unbiased Proteoform Detection

A Practical and Analytical Comparative Study of Gel-Based Top-Down and Gel-Free Bottom-Up Proteomics Including Unbiased Proteoform Detection

Proteomics is an indispensable analytical technique to study the dynamic functioning of biological systems via different proteins and their proteoforms. In recent years, bottom-up shotgun has become more popular than gel-based top-down proteomics. The current study examined the qualitative and quant...

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Bibliographic Details
Main Authors: Huriye Ercan, Ulrike Resch, Felicia Hsu, Goran Mitulovic, Andrea Bileck, Christopher Gerner, Jae-Won Yang, Margarethe Geiger, Ingrid Miller, Maria Zellner
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
top-down proteomics
2D-DIGE
bottom-up proteomics
shotgun proteomics
proteoforms
post-translational modification (PTM)
Online Access:https://www.mdpi.com/2073-4409/12/5/747

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