Biodegradable and Biocompatible Adhesives for the Effective Stabilisation, Repair and Regeneration of Bone
Bone defects and complex fractures present significant challenges for orthopaedic surgeons. Current surgical procedures involve the reconstruction and mechanical stabilisation of complex fractures using metal hardware (i.e., wires, plates and screws). However, these procedures often result in poor h...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/9/6/250 |
| _version_ | 1797489885548904448 |
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| author | Antzela Tzagiollari Helen O. McCarthy Tanya J. Levingstone Nicholas J. Dunne |
| author_facet | Antzela Tzagiollari Helen O. McCarthy Tanya J. Levingstone Nicholas J. Dunne |
| author_sort | Antzela Tzagiollari |
| collection | DOAJ |
| description | Bone defects and complex fractures present significant challenges for orthopaedic surgeons. Current surgical procedures involve the reconstruction and mechanical stabilisation of complex fractures using metal hardware (i.e., wires, plates and screws). However, these procedures often result in poor healing. An injectable, biocompatible, biodegradable bone adhesive that could glue bone fragments back together would present a highly attractive solution. A bone adhesive that meets the many clinical requirements for such an application has yet to be developed. While synthetic and biological polymer-based adhesives (e.g., cyanoacrylates, PMMA, fibrin, etc.) have been used effectively as bone void fillers, these materials lack biomechanical integrity and demonstrate poor injectability, which limits the clinical effectiveness and potential for minimally invasive delivery. This systematic review summarises conventional approaches and recent developments in the area of bone adhesives for orthopaedic applications. The required properties for successful bone repair adhesives, which include suitable injectability, setting characteristics, mechanical properties, biocompatibility and an ability to promote new bone formation, are highlighted. Finally, the potential to achieve repair of challenging bone voids and fractures as well as the potential of new bioinspired adhesives and the future directions relating to their clinical development are discussed. |
| first_indexed | 2024-03-10T00:24:01Z |
| format | Article |
| id | doaj.art-aa1cddde95db47469bf0a6c0fc04c477 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T00:24:01Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-aa1cddde95db47469bf0a6c0fc04c4772023-11-23T15:38:04ZengMDPI AGBioengineering2306-53542022-06-019625010.3390/bioengineering9060250Biodegradable and Biocompatible Adhesives for the Effective Stabilisation, Repair and Regeneration of BoneAntzela Tzagiollari0Helen O. McCarthy1Tanya J. Levingstone2Nicholas J. Dunne3School of Mechanical and Manufacturing Engineering, Dublin City University, D09 NA55 Dublin, IrelandSchool of Pharmacy, Queen’s University, Belfast BT9 7BL, UKSchool of Mechanical and Manufacturing Engineering, Dublin City University, D09 NA55 Dublin, IrelandSchool of Mechanical and Manufacturing Engineering, Dublin City University, D09 NA55 Dublin, IrelandBone defects and complex fractures present significant challenges for orthopaedic surgeons. Current surgical procedures involve the reconstruction and mechanical stabilisation of complex fractures using metal hardware (i.e., wires, plates and screws). However, these procedures often result in poor healing. An injectable, biocompatible, biodegradable bone adhesive that could glue bone fragments back together would present a highly attractive solution. A bone adhesive that meets the many clinical requirements for such an application has yet to be developed. While synthetic and biological polymer-based adhesives (e.g., cyanoacrylates, PMMA, fibrin, etc.) have been used effectively as bone void fillers, these materials lack biomechanical integrity and demonstrate poor injectability, which limits the clinical effectiveness and potential for minimally invasive delivery. This systematic review summarises conventional approaches and recent developments in the area of bone adhesives for orthopaedic applications. The required properties for successful bone repair adhesives, which include suitable injectability, setting characteristics, mechanical properties, biocompatibility and an ability to promote new bone formation, are highlighted. Finally, the potential to achieve repair of challenging bone voids and fractures as well as the potential of new bioinspired adhesives and the future directions relating to their clinical development are discussed.https://www.mdpi.com/2306-5354/9/6/250bone fracturesbioadhesivesbone repairingbiomimetic adhesives |
| spellingShingle | Antzela Tzagiollari Helen O. McCarthy Tanya J. Levingstone Nicholas J. Dunne Biodegradable and Biocompatible Adhesives for the Effective Stabilisation, Repair and Regeneration of Bone Bioengineering bone fractures bioadhesives bone repairing biomimetic adhesives |
| title | Biodegradable and Biocompatible Adhesives for the Effective Stabilisation, Repair and Regeneration of Bone |
| title_full | Biodegradable and Biocompatible Adhesives for the Effective Stabilisation, Repair and Regeneration of Bone |
| title_fullStr | Biodegradable and Biocompatible Adhesives for the Effective Stabilisation, Repair and Regeneration of Bone |
| title_full_unstemmed | Biodegradable and Biocompatible Adhesives for the Effective Stabilisation, Repair and Regeneration of Bone |
| title_short | Biodegradable and Biocompatible Adhesives for the Effective Stabilisation, Repair and Regeneration of Bone |
| title_sort | biodegradable and biocompatible adhesives for the effective stabilisation repair and regeneration of bone |
| topic | bone fractures bioadhesives bone repairing biomimetic adhesives |
| url | https://www.mdpi.com/2306-5354/9/6/250 |
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