Radiation therapy improves CAR T cell activity in acute lymphoblastic leukemia

Radiation therapy improves CAR T cell activity in acute lymphoblastic leukemia

Abstract Autologous T cells engineered to express a chimeric antigen receptor (CAR) specific for CD19 are approved for the treatment of various CD19+ hematological malignancies. While CAR T cells induce objective responses in a majority of patients, relapse frequently occurs upon loss of CD19 expres...

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Bibliographic Details
Main Authors: Mayumi Sugita, Takahiro Yamazaki, Mohammad Alhomoud, Jérémie Martinet, Jean-Baptiste Latouche, Encouse Golden, Olivier Boyer, Koen Van Besien, Silvia C. Formenti, Lorenzo Galluzzi, Monica L. Guzman
Format: Article
Language:English
Published: Nature Publishing Group 2023-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05829-6

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