Advanced Phytochemical-Based Nanocarrier Systems for the Treatment of Breast Cancer
As the world’s most prevalent cancer, breast cancer imposes a significant societal health burden and is among the leading causes of cancer death in women worldwide. Despite the notable improvements in survival in countries with early detection programs, combined with different modes of treatment to...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/4/1023 |
| _version_ | 1797621947533623296 |
|---|---|
| author | Vivek P. Chavda Lakshmi Vineela Nalla Pankti Balar Rajashri Bezbaruah Vasso Apostolopoulos Rajeev K. Singla Avinash Khadela Lalitkumar Vora Vladimir N. Uversky |
| author_facet | Vivek P. Chavda Lakshmi Vineela Nalla Pankti Balar Rajashri Bezbaruah Vasso Apostolopoulos Rajeev K. Singla Avinash Khadela Lalitkumar Vora Vladimir N. Uversky |
| author_sort | Vivek P. Chavda |
| collection | DOAJ |
| description | As the world’s most prevalent cancer, breast cancer imposes a significant societal health burden and is among the leading causes of cancer death in women worldwide. Despite the notable improvements in survival in countries with early detection programs, combined with different modes of treatment to eradicate invasive disease, the current chemotherapy regimen faces significant challenges associated with chemotherapy-induced side effects and the development of drug resistance. Therefore, serious concerns regarding current chemotherapeutics are pressuring researchers to develop alternative therapeutics with better efficacy and safety. Due to their extremely biocompatible nature and efficient destruction of cancer cells via numerous mechanisms, phytochemicals have emerged as one of the attractive alternative therapies for chemotherapeutics to treat breast cancer. Additionally, phytofabricated nanocarriers, whether used alone or in conjunction with other loaded phytotherapeutics or chemotherapeutics, showed promising results in treating breast cancer. In the current review, we emphasize the anticancer activity of phytochemical-instigated nanocarriers and phytochemical-loaded nanocarriers against breast cancer both in vitro and in vivo. Since diverse mechanisms are implicated in the anticancer activity of phytochemicals, a strong emphasis is placed on the anticancer pathways underlying their action. Furthermore, we discuss the selective targeted delivery of phytofabricated nanocarriers to cancer cells and consider research gaps, recent developments, and the druggability of phytoceuticals. Combining phytochemical and chemotherapeutic agents with nanotechnology might have far-reaching impacts in the future. |
| first_indexed | 2024-03-11T09:03:17Z |
| format | Article |
| id | doaj.art-aa1f9359b6734f459dcd561f184fef88 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:03:17Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-aa1f9359b6734f459dcd561f184fef882023-11-16T19:35:02ZengMDPI AGCancers2072-66942023-02-01154102310.3390/cancers15041023Advanced Phytochemical-Based Nanocarrier Systems for the Treatment of Breast CancerVivek P. Chavda0Lakshmi Vineela Nalla1Pankti Balar2Rajashri Bezbaruah3Vasso Apostolopoulos4Rajeev K. Singla5Avinash Khadela6Lalitkumar Vora7Vladimir N. Uversky8Department of Pharmaceutics and Pharmaceutical Technology, L. M. College of Pharmacy, Ahmedabad 380009, Gujarat, IndiaDepartment of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur 522302, Andhra Pradesh, IndiaPharmacy Section, L. M. College of Pharmacy, Ahmedabad 380009, Gujarat, IndiaDepartment of Pharmaceutical Sciences, Faculty of Science and Engineering, Dibrugarh University, Dibrugarh 786004, Assam, IndiaInstitute for Health and Sport, Victoria University, Melbourne, VIC 3030, AustraliaInstitutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Xinchuan Road 2222, Chengdu 610064, ChinaDepartment of Pharmacology, L. M. College of Pharmacy, Ahmedabad 380009, Gujarat, IndiaSchool of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKDepartment of Molecular Medicine, Byrd Alzheimer’s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33613, USAAs the world’s most prevalent cancer, breast cancer imposes a significant societal health burden and is among the leading causes of cancer death in women worldwide. Despite the notable improvements in survival in countries with early detection programs, combined with different modes of treatment to eradicate invasive disease, the current chemotherapy regimen faces significant challenges associated with chemotherapy-induced side effects and the development of drug resistance. Therefore, serious concerns regarding current chemotherapeutics are pressuring researchers to develop alternative therapeutics with better efficacy and safety. Due to their extremely biocompatible nature and efficient destruction of cancer cells via numerous mechanisms, phytochemicals have emerged as one of the attractive alternative therapies for chemotherapeutics to treat breast cancer. Additionally, phytofabricated nanocarriers, whether used alone or in conjunction with other loaded phytotherapeutics or chemotherapeutics, showed promising results in treating breast cancer. In the current review, we emphasize the anticancer activity of phytochemical-instigated nanocarriers and phytochemical-loaded nanocarriers against breast cancer both in vitro and in vivo. Since diverse mechanisms are implicated in the anticancer activity of phytochemicals, a strong emphasis is placed on the anticancer pathways underlying their action. Furthermore, we discuss the selective targeted delivery of phytofabricated nanocarriers to cancer cells and consider research gaps, recent developments, and the druggability of phytoceuticals. Combining phytochemical and chemotherapeutic agents with nanotechnology might have far-reaching impacts in the future.https://www.mdpi.com/2072-6694/15/4/1023phytochemicalsnanocarriersbreast cancerchemotherapydrug resistance |
| spellingShingle | Vivek P. Chavda Lakshmi Vineela Nalla Pankti Balar Rajashri Bezbaruah Vasso Apostolopoulos Rajeev K. Singla Avinash Khadela Lalitkumar Vora Vladimir N. Uversky Advanced Phytochemical-Based Nanocarrier Systems for the Treatment of Breast Cancer Cancers phytochemicals nanocarriers breast cancer chemotherapy drug resistance |
| title | Advanced Phytochemical-Based Nanocarrier Systems for the Treatment of Breast Cancer |
| title_full | Advanced Phytochemical-Based Nanocarrier Systems for the Treatment of Breast Cancer |
| title_fullStr | Advanced Phytochemical-Based Nanocarrier Systems for the Treatment of Breast Cancer |
| title_full_unstemmed | Advanced Phytochemical-Based Nanocarrier Systems for the Treatment of Breast Cancer |
| title_short | Advanced Phytochemical-Based Nanocarrier Systems for the Treatment of Breast Cancer |
| title_sort | advanced phytochemical based nanocarrier systems for the treatment of breast cancer |
| topic | phytochemicals nanocarriers breast cancer chemotherapy drug resistance |
| url | https://www.mdpi.com/2072-6694/15/4/1023 |
| work_keys_str_mv | AT vivekpchavda advancedphytochemicalbasednanocarriersystemsforthetreatmentofbreastcancer AT lakshmivineelanalla advancedphytochemicalbasednanocarriersystemsforthetreatmentofbreastcancer AT panktibalar advancedphytochemicalbasednanocarriersystemsforthetreatmentofbreastcancer AT rajashribezbaruah advancedphytochemicalbasednanocarriersystemsforthetreatmentofbreastcancer AT vassoapostolopoulos advancedphytochemicalbasednanocarriersystemsforthetreatmentofbreastcancer AT rajeevksingla advancedphytochemicalbasednanocarriersystemsforthetreatmentofbreastcancer AT avinashkhadela advancedphytochemicalbasednanocarriersystemsforthetreatmentofbreastcancer AT lalitkumarvora advancedphytochemicalbasednanocarriersystemsforthetreatmentofbreastcancer AT vladimirnuversky advancedphytochemicalbasednanocarriersystemsforthetreatmentofbreastcancer |