Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models
Cancer is a widespread but dangerous disease that can strike anyone and is the second 1leading cause of death worldwide. Prostate cancer, in particular, is a prevalent cancer that occurs in men, and much research is being done on its treatment. Although chemical drugs are effective, they have variou...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9240 |
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| author | Se Hyo Jeong Hun Hwan Kim Min Young Park Pritam Bhagwan Bhosale Abuyaseer Abusaliya Chung Kil Won Kwang Il Park Eunhye Kim Jeong Doo Heo Hyun Wook Kim Meejung Ahn Je Kyung Seong Gon Sup Kim |
| author_facet | Se Hyo Jeong Hun Hwan Kim Min Young Park Pritam Bhagwan Bhosale Abuyaseer Abusaliya Chung Kil Won Kwang Il Park Eunhye Kim Jeong Doo Heo Hyun Wook Kim Meejung Ahn Je Kyung Seong Gon Sup Kim |
| author_sort | Se Hyo Jeong |
| collection | DOAJ |
| description | Cancer is a widespread but dangerous disease that can strike anyone and is the second 1leading cause of death worldwide. Prostate cancer, in particular, is a prevalent cancer that occurs in men, and much research is being done on its treatment. Although chemical drugs are effective, they have various side effects, and accordingly, anticancer drugs using natural products are emerging. To date, many natural candidates have been discovered, and new drugs are being developed as drugs to treat prostate cancer. Representative candidate compounds that have been studied to be effective in prostate cancer include apigenin, acacetin and tangeretin of the flavone family among flavonoids. In this review, we look at the effects of these three flavones on prostate cancer cells via apoptosis in vitro and in vivo. Furthermore, in addition to the existing drugs, we suggest the three flavones and their effectiveness as natural anticancer agents, a treatment model for prostate cancer. |
| first_indexed | 2024-03-11T03:06:51Z |
| format | Article |
| id | doaj.art-aa205016d4494064bafbb5070ae0e142 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:06:51Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-aa205016d4494064bafbb5070ae0e1422023-11-18T07:56:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411924010.3390/ijms24119240Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate ModelsSe Hyo Jeong0Hun Hwan Kim1Min Young Park2Pritam Bhagwan Bhosale3Abuyaseer Abusaliya4Chung Kil Won5Kwang Il Park6Eunhye Kim7Jeong Doo Heo8Hyun Wook Kim9Meejung Ahn10Je Kyung Seong11Gon Sup Kim12Department of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Republic of KoreaDepartment of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Republic of KoreaDepartment of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Republic of KoreaDepartment of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Republic of KoreaDepartment of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Republic of KoreaDepartment of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Republic of KoreaDepartment of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Republic of KoreaDepartment of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Republic of KoreaBiological Resources Research Group, Gyeongnam Department of Environment Toxicology and Chemistry, Korea Institute of Toxicology, 17 Jegok-gil, Jinju 52834, Republic of KoreaDivision of Animal Bioscience & Integrated Biotechnology, Jinju 52725, Republic of KoreaDepartment of Animal Science, College of Life Science, Sangji University, Wonju 26339, Republic of KoreaLaboratory of Developmental Biology and Genomics, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of KoreaDepartment of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Republic of KoreaCancer is a widespread but dangerous disease that can strike anyone and is the second 1leading cause of death worldwide. Prostate cancer, in particular, is a prevalent cancer that occurs in men, and much research is being done on its treatment. Although chemical drugs are effective, they have various side effects, and accordingly, anticancer drugs using natural products are emerging. To date, many natural candidates have been discovered, and new drugs are being developed as drugs to treat prostate cancer. Representative candidate compounds that have been studied to be effective in prostate cancer include apigenin, acacetin and tangeretin of the flavone family among flavonoids. In this review, we look at the effects of these three flavones on prostate cancer cells via apoptosis in vitro and in vivo. Furthermore, in addition to the existing drugs, we suggest the three flavones and their effectiveness as natural anticancer agents, a treatment model for prostate cancer.https://www.mdpi.com/1422-0067/24/11/9240flavonoidsflavonesprostate cancercancer cell deathapoptosis |
| spellingShingle | Se Hyo Jeong Hun Hwan Kim Min Young Park Pritam Bhagwan Bhosale Abuyaseer Abusaliya Chung Kil Won Kwang Il Park Eunhye Kim Jeong Doo Heo Hyun Wook Kim Meejung Ahn Je Kyung Seong Gon Sup Kim Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models International Journal of Molecular Sciences flavonoids flavones prostate cancer cancer cell death apoptosis |
| title | Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models |
| title_full | Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models |
| title_fullStr | Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models |
| title_full_unstemmed | Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models |
| title_short | Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models |
| title_sort | flavones the apoptosis in prostate cancer of three flavones selected as therapeutic candidate models |
| topic | flavonoids flavones prostate cancer cancer cell death apoptosis |
| url | https://www.mdpi.com/1422-0067/24/11/9240 |
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