Kynurenine pathway metabolism and neuroinflammatory disease
Immune-mediated activation of tryptophan (TRYP) catabolism via the kynurenine pathway (KP) is a consistent finding in all inflammatory disorders. Several studies by our group and others have examined the neurotoxic potential of neuroreactive TRYP metabolites, including quinolinic acid (QUIN) in neur...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2017-01-01
|
| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=1;spage=39;epage=42;aulast=Braidy |
| _version_ | 1819095804666707968 |
|---|---|
| author | Nady Braidy Ross Grant |
| author_facet | Nady Braidy Ross Grant |
| author_sort | Nady Braidy |
| collection | DOAJ |
| description | Immune-mediated activation of tryptophan (TRYP) catabolism via the kynurenine pathway (KP) is a consistent finding in all inflammatory disorders. Several studies by our group and others have examined the neurotoxic potential of neuroreactive TRYP metabolites, including quinolinic acid (QUIN) in neuroinflammatory neurological disorders, including Alzheimer's disease (AD), multiple sclerosis, amylotropic lateral sclerosis (ALS), and AIDS related dementia complex (ADC). Our current work aims to determine whether there is any benefit to the affected individuals in enhancing the catabolism of TRYP via the KP during an immune response. Under physiological conditions, QUIN is metabolized to the essential pyridine nucleotide, nicotinamide adenine dinucleotide (NAD+), which represents an important metabolic cofactor and electron transporter. NAD+ also serves as a substrate for the DNA 'nick sensor' and putative nuclear repair enzyme, poly(ADP-ribose) polymerase (PARP). Free radical initiated DNA damage, PARP activation and NAD+ depletion may contribute to brain dysfunction and cell death in neuroinflammatory disease. |
| first_indexed | 2024-12-21T23:49:07Z |
| format | Article |
| id | doaj.art-aa25e25ecae04523bda8f11a3d543560 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-21T23:49:07Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-aa25e25ecae04523bda8f11a3d5435602022-12-21T18:45:59ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742017-01-01121394210.4103/1673-5374.198971Kynurenine pathway metabolism and neuroinflammatory diseaseNady BraidyRoss GrantImmune-mediated activation of tryptophan (TRYP) catabolism via the kynurenine pathway (KP) is a consistent finding in all inflammatory disorders. Several studies by our group and others have examined the neurotoxic potential of neuroreactive TRYP metabolites, including quinolinic acid (QUIN) in neuroinflammatory neurological disorders, including Alzheimer's disease (AD), multiple sclerosis, amylotropic lateral sclerosis (ALS), and AIDS related dementia complex (ADC). Our current work aims to determine whether there is any benefit to the affected individuals in enhancing the catabolism of TRYP via the KP during an immune response. Under physiological conditions, QUIN is metabolized to the essential pyridine nucleotide, nicotinamide adenine dinucleotide (NAD+), which represents an important metabolic cofactor and electron transporter. NAD+ also serves as a substrate for the DNA 'nick sensor' and putative nuclear repair enzyme, poly(ADP-ribose) polymerase (PARP). Free radical initiated DNA damage, PARP activation and NAD+ depletion may contribute to brain dysfunction and cell death in neuroinflammatory disease.http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=1;spage=39;epage=42;aulast=Braidykynurenine pathway; tryptophan; NAD+; PARP; inflammation |
| spellingShingle | Nady Braidy Ross Grant Kynurenine pathway metabolism and neuroinflammatory disease Neural Regeneration Research kynurenine pathway; tryptophan; NAD+; PARP; inflammation |
| title | Kynurenine pathway metabolism and neuroinflammatory disease |
| title_full | Kynurenine pathway metabolism and neuroinflammatory disease |
| title_fullStr | Kynurenine pathway metabolism and neuroinflammatory disease |
| title_full_unstemmed | Kynurenine pathway metabolism and neuroinflammatory disease |
| title_short | Kynurenine pathway metabolism and neuroinflammatory disease |
| title_sort | kynurenine pathway metabolism and neuroinflammatory disease |
| topic | kynurenine pathway; tryptophan; NAD+; PARP; inflammation |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=1;spage=39;epage=42;aulast=Braidy |
| work_keys_str_mv | AT nadybraidy kynureninepathwaymetabolismandneuroinflammatorydisease AT rossgrant kynureninepathwaymetabolismandneuroinflammatorydisease |