Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases
Abstract Lysosomal acidification dysfunction has been implicated as a key driving factor in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. Multiple genetic factors have been linked to lysosomal de-acidification through impairing the vacuolar-ty...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Translational Neurodegeneration |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40035-023-00362-0 |
| _version_ | 1797806532371415040 |
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| author | Chih Hung Lo Jialiu Zeng |
| author_facet | Chih Hung Lo Jialiu Zeng |
| author_sort | Chih Hung Lo |
| collection | DOAJ |
| description | Abstract Lysosomal acidification dysfunction has been implicated as a key driving factor in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. Multiple genetic factors have been linked to lysosomal de-acidification through impairing the vacuolar-type ATPase and ion channels on the organelle membrane. Similar lysosomal abnormalities are also present in sporadic forms of neurodegeneration, although the underlying pathogenic mechanisms are unclear and remain to be investigated. Importantly, recent studies have revealed early occurrence of lysosomal acidification impairment before the onset of neurodegeneration and late-stage pathology. However, there is a lack of methods for organelle pH monitoring in vivo and a dearth of lysosome-acidifying therapeutic agents. Here, we summarize and present evidence for the notion of defective lysosomal acidification as an early indicator of neurodegeneration and urge the critical need for technological advancement in developing tools for lysosomal pH monitoring and detection both in vivo and for clinical applications. We further discuss current preclinical pharmacological agents that modulate lysosomal acidification, including small molecules and nanomedicine, and their potential clinical translation into lysosome-targeting therapies. Both timely detection of lysosomal dysfunction and development of therapeutics that restore lysosomal function represent paradigm shifts in targeting neurodegenerative diseases. |
| first_indexed | 2024-03-13T06:08:41Z |
| format | Article |
| id | doaj.art-aa266ef21cc34217b4ed526a56272f84 |
| institution | Directory Open Access Journal |
| issn | 2047-9158 |
| language | English |
| last_indexed | 2024-03-13T06:08:41Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Translational Neurodegeneration |
| spelling | doaj.art-aa266ef21cc34217b4ed526a56272f842023-06-11T11:23:44ZengBMCTranslational Neurodegeneration2047-91582023-06-0112111110.1186/s40035-023-00362-0Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseasesChih Hung Lo0Jialiu Zeng1Lee Kong Chian School of Medicine, Nanyang Technological UniversityLee Kong Chian School of Medicine, Nanyang Technological UniversityAbstract Lysosomal acidification dysfunction has been implicated as a key driving factor in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. Multiple genetic factors have been linked to lysosomal de-acidification through impairing the vacuolar-type ATPase and ion channels on the organelle membrane. Similar lysosomal abnormalities are also present in sporadic forms of neurodegeneration, although the underlying pathogenic mechanisms are unclear and remain to be investigated. Importantly, recent studies have revealed early occurrence of lysosomal acidification impairment before the onset of neurodegeneration and late-stage pathology. However, there is a lack of methods for organelle pH monitoring in vivo and a dearth of lysosome-acidifying therapeutic agents. Here, we summarize and present evidence for the notion of defective lysosomal acidification as an early indicator of neurodegeneration and urge the critical need for technological advancement in developing tools for lysosomal pH monitoring and detection both in vivo and for clinical applications. We further discuss current preclinical pharmacological agents that modulate lysosomal acidification, including small molecules and nanomedicine, and their potential clinical translation into lysosome-targeting therapies. Both timely detection of lysosomal dysfunction and development of therapeutics that restore lysosomal function represent paradigm shifts in targeting neurodegenerative diseases.https://doi.org/10.1186/s40035-023-00362-0Neurodegenerative diseasesAlzheimer’s diseaseParkinson’s diseaseLysosomal de-acidificationAutophagy dysfunctionEarly detection |
| spellingShingle | Chih Hung Lo Jialiu Zeng Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases Translational Neurodegeneration Neurodegenerative diseases Alzheimer’s disease Parkinson’s disease Lysosomal de-acidification Autophagy dysfunction Early detection |
| title | Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases |
| title_full | Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases |
| title_fullStr | Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases |
| title_full_unstemmed | Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases |
| title_short | Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases |
| title_sort | defective lysosomal acidification a new prognostic marker and therapeutic target for neurodegenerative diseases |
| topic | Neurodegenerative diseases Alzheimer’s disease Parkinson’s disease Lysosomal de-acidification Autophagy dysfunction Early detection |
| url | https://doi.org/10.1186/s40035-023-00362-0 |
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